1YDE

Crystal Structure of Human Retinal Short-Chain Dehydrogenase/Reductase 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006706	biological_process	steroid catabolic process
A	0008202	biological_process	steroid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0042802	molecular_function	identical protein binding
A	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
B	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006706	biological_process	steroid catabolic process
B	0008202	biological_process	steroid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0042802	molecular_function	identical protein binding
B	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
C	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006706	biological_process	steroid catabolic process
C	0008202	biological_process	steroid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0042802	molecular_function	identical protein binding
C	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
D	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006706	biological_process	steroid catabolic process
D	0008202	biological_process	steroid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0042802	molecular_function	identical protein binding
D	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
E	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006706	biological_process	steroid catabolic process
E	0008202	biological_process	steroid metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0042802	molecular_function	identical protein binding
E	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
F	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006706	biological_process	steroid catabolic process
F	0008202	biological_process	steroid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0042802	molecular_function	identical protein binding
F	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
G	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006629	biological_process	lipid metabolic process
G	0006706	biological_process	steroid catabolic process
G	0008202	biological_process	steroid metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0042802	molecular_function	identical protein binding
G	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
H	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006629	biological_process	lipid metabolic process
H	0006706	biological_process	steroid catabolic process
H	0008202	biological_process	steroid metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0042802	molecular_function	identical protein binding
H	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
I	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006629	biological_process	lipid metabolic process
I	0006706	biological_process	steroid catabolic process
I	0008202	biological_process	steroid metabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0042802	molecular_function	identical protein binding
I	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
J	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006629	biological_process	lipid metabolic process
J	0006706	biological_process	steroid catabolic process
J	0008202	biological_process	steroid metabolic process
J	0016491	molecular_function	oxidoreductase activity
J	0042802	molecular_function	identical protein binding
J	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
K	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006629	biological_process	lipid metabolic process
K	0006706	biological_process	steroid catabolic process
K	0008202	biological_process	steroid metabolic process
K	0016491	molecular_function	oxidoreductase activity
K	0042802	molecular_function	identical protein binding
K	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
L	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006629	biological_process	lipid metabolic process
L	0006706	biological_process	steroid catabolic process
L	0008202	biological_process	steroid metabolic process
L	0016491	molecular_function	oxidoreductase activity
L	0042802	molecular_function	identical protein binding
L	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
M	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006629	biological_process	lipid metabolic process
M	0006706	biological_process	steroid catabolic process
M	0008202	biological_process	steroid metabolic process
M	0016491	molecular_function	oxidoreductase activity
M	0042802	molecular_function	identical protein binding
M	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
N	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006629	biological_process	lipid metabolic process
N	0006706	biological_process	steroid catabolic process
N	0008202	biological_process	steroid metabolic process
N	0016491	molecular_function	oxidoreductase activity
N	0042802	molecular_function	identical protein binding
N	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
O	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006629	biological_process	lipid metabolic process
O	0006706	biological_process	steroid catabolic process
O	0008202	biological_process	steroid metabolic process
O	0016491	molecular_function	oxidoreductase activity
O	0042802	molecular_function	identical protein binding
O	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
P	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006629	biological_process	lipid metabolic process
P	0006706	biological_process	steroid catabolic process
P	0008202	biological_process	steroid metabolic process
P	0016491	molecular_function	oxidoreductase activity
P	0042802	molecular_function	identical protein binding
P	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlvgaigqaqAvpYVATKGAVtAMTkALA

Chain	Residue	Details
A	SER141-ALA169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR154
J	TYR154
K	TYR154
L	TYR154
M	TYR154
N	TYR154
O	TYR154
P	TYR154
B	TYR154
C	TYR154
D	TYR154
E	TYR154
F	TYR154
G	TYR154
H	TYR154
I	TYR154

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site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	VAL13
D	VAL13
D	SER141
D	LYS158
E	VAL13
E	SER141
E	LYS158
F	VAL13
F	SER141
F	LYS158
G	VAL13
A	SER141
G	SER141
G	LYS158
H	VAL13
H	SER141
H	LYS158
I	VAL13
I	SER141
I	LYS158
J	VAL13
J	SER141
A	LYS158
J	LYS158
K	VAL13
K	SER141
K	LYS158
L	VAL13
L	SER141
L	LYS158
M	VAL13
M	SER141
M	LYS158
B	VAL13
N	VAL13
N	SER141
N	LYS158
O	VAL13
O	SER141
O	LYS158
P	VAL13
P	SER141
P	LYS158
B	SER141
B	LYS158
C	VAL13
C	SER141
C	LYS158

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