1Y9A

Alcohol Dehydrogenase from Entamoeba histolotica in complex with cacodylate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0050009	molecular_function	isopropanol dehydrogenase (NADP+) activity
C	0005737	cellular_component	cytoplasm
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0050009	molecular_function	isopropanol dehydrogenase (NADP+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1000

Chain	Residue
A	CYS37
A	SER39
A	HIS59
A	ASP150
A	CAC1001

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CAC A 1001

Chain	Residue
A	THR154
A	MET285
A	ZN1000
A	HOH1034
A	CYS37
A	SER39
A	HIS59
A	ASP150

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	ASP51
A	HIS53
A	HIS202
A	HOH1330

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 1004

Chain	Residue
A	CYS22
A	PRO24
A	GLY69
A	SER70
A	HOH1098

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1005

Chain	Residue
A	HIS360
A	HIS360
A	HOH1006
A	HOH1007

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 2000

Chain	Residue
C	CYS37
C	SER39
C	HIS59
C	ASP150
C	CAC2001

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC C 2001

Chain	Residue
C	CYS37
C	SER39
C	HIS59
C	TRP110
C	ASP150
C	THR154
C	MET285
C	ZN2000
C	HOH2018

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2002

Chain	Residue
C	ASP51
C	ASP51
C	HIS53
C	HIS53

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 2008

Chain	Residue
C	CYS22
C	PRO24
C	GLY69
C	SER70
C	HOH2276

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 2009

Chain	Residue
A	LYS304
C	GLY167
C	ASP237
C	HOH2010
C	HOH2011

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1003

Chain	Residue
A	GLY98
A	MET101
A	HIS157
A	HIS287
A	HOH1025
A	HOH1165

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 2003

Chain	Residue
C	GLY98
C	MET101
C	HIS157
C	HIS287
C	HOH2049
C	HOH2161

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 2004

Chain	Residue
C	ILE206
C	LYS318
C	PHE324
C	ARG350
C	HOH2047

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 2005

Chain	Residue
C	HIS289
C	HIS291
C	HIS291
C	HOH2034
C	HOH2034
C	HOH2178

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 2006

Chain	Residue
A	ASN187
A	HIS188
A	HOH1142
A	HOH1143
C	ASN187
C	HIS188
C	HOH2394

---

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaVGQivkvGslV

Chain	Residue	Details
A	GLY58-VAL72

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:20102159

Chain	Residue	Details
A	THR43
A	ILE65
A	VAL66
A	PHE156
C	THR43
C	ILE65
C	VAL66
C	PHE156

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	MET181
C	LYS346
A	CYS204
A	VAL224
A	GLY271
A	LYS346
C	MET181
C	CYS204
C	VAL224
C	GLY271

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
A	HIS42
A	SER39

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
C	HIS42
C	SER39

---