Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1Y7H

Structural and biochemical studies identify tobacco SABP2 as a methylsalicylate esterase and further implicate it in plant innate immunity, Northeast Structural Genomics Target AR2241

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0006952	biological_process	defense response
A	0009694	biological_process	jasmonic acid metabolic process
A	0009696	biological_process	salicylic acid metabolic process
A	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0045087	biological_process	innate immune response
A	0080030	molecular_function	methyl indole-3-acetate esterase activity
A	0080031	molecular_function	methyl salicylate esterase activity
A	0080032	molecular_function	methyl jasmonate esterase activity
B	0002376	biological_process	immune system process
B	0006952	biological_process	defense response
B	0009694	biological_process	jasmonic acid metabolic process
B	0009696	biological_process	salicylic acid metabolic process
B	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0045087	biological_process	innate immune response
B	0080030	molecular_function	methyl indole-3-acetate esterase activity
B	0080031	molecular_function	methyl salicylate esterase activity
B	0080032	molecular_function	methyl jasmonate esterase activity
C	0002376	biological_process	immune system process
C	0006952	biological_process	defense response
C	0009694	biological_process	jasmonic acid metabolic process
C	0009696	biological_process	salicylic acid metabolic process
C	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
C	0016298	molecular_function	lipase activity
C	0016787	molecular_function	hydrolase activity
C	0045087	biological_process	innate immune response
C	0080030	molecular_function	methyl indole-3-acetate esterase activity
C	0080031	molecular_function	methyl salicylate esterase activity
C	0080032	molecular_function	methyl jasmonate esterase activity
D	0002376	biological_process	immune system process
D	0006952	biological_process	defense response
D	0009694	biological_process	jasmonic acid metabolic process
D	0009696	biological_process	salicylic acid metabolic process
D	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
D	0016298	molecular_function	lipase activity
D	0016787	molecular_function	hydrolase activity
D	0045087	biological_process	innate immune response
D	0080030	molecular_function	methyl indole-3-acetate esterase activity
D	0080031	molecular_function	methyl salicylate esterase activity
D	0080032	molecular_function	methyl jasmonate esterase activity
E	0002376	biological_process	immune system process
E	0006952	biological_process	defense response
E	0009694	biological_process	jasmonic acid metabolic process
E	0009696	biological_process	salicylic acid metabolic process
E	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
E	0016298	molecular_function	lipase activity
E	0016787	molecular_function	hydrolase activity
E	0045087	biological_process	innate immune response
E	0080030	molecular_function	methyl indole-3-acetate esterase activity
E	0080031	molecular_function	methyl salicylate esterase activity
E	0080032	molecular_function	methyl jasmonate esterase activity
F	0002376	biological_process	immune system process
F	0006952	biological_process	defense response
F	0009694	biological_process	jasmonic acid metabolic process
F	0009696	biological_process	salicylic acid metabolic process
F	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
F	0016298	molecular_function	lipase activity
F	0016787	molecular_function	hydrolase activity
F	0045087	biological_process	innate immune response
F	0080030	molecular_function	methyl indole-3-acetate esterase activity
F	0080031	molecular_function	methyl salicylate esterase activity
F	0080032	molecular_function	methyl jasmonate esterase activity
G	0002376	biological_process	immune system process
G	0006952	biological_process	defense response
G	0009694	biological_process	jasmonic acid metabolic process
G	0009696	biological_process	salicylic acid metabolic process
G	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
G	0016298	molecular_function	lipase activity
G	0016787	molecular_function	hydrolase activity
G	0045087	biological_process	innate immune response
G	0080030	molecular_function	methyl indole-3-acetate esterase activity
G	0080031	molecular_function	methyl salicylate esterase activity
G	0080032	molecular_function	methyl jasmonate esterase activity
H	0002376	biological_process	immune system process
H	0006952	biological_process	defense response
H	0009694	biological_process	jasmonic acid metabolic process
H	0009696	biological_process	salicylic acid metabolic process
H	0009862	biological_process	systemic acquired resistance, salicylic acid mediated signaling pathway
H	0016298	molecular_function	lipase activity
H	0016787	molecular_function	hydrolase activity
H	0045087	biological_process	innate immune response
H	0080030	molecular_function	methyl indole-3-acetate esterase activity
H	0080031	molecular_function	methyl salicylate esterase activity
H	0080032	molecular_function	methyl jasmonate esterase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN A 291

Chain	Residue
A	THR147
A	SER180
A	LEU181
A	PHE182
A	MSE183
A	GLU184

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN B 292

Chain	Residue
B	MSE183
B	HOH293
B	THR147
B	MSE149
B	LEU181

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SCN C 293

Chain	Residue
C	THR147
C	MSE149
C	SER180
C	LEU181
C	PHE182
C	MSE183
C	GLU184

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN D 294

Chain	Residue
D	THR147
D	SER148
D	MSE149
D	LEU181
D	MSE183
D	HOH314

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN E 295

Chain	Residue
E	THR147
E	SER180
E	LEU181
E	PHE182
E	MSE183

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SCN F 296

Chain	Residue
F	THR147
F	LEU181
F	MSE183

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SCN G 297

Chain	Residue
G	PHE136
G	THR147
G	MSE149
G	LEU181
G	PHE182
G	MSE183
G	GLU184

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN H 298

Chain	Residue
H	THR147
H	LEU181
H	PHE182
H	MSE183

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VILVGHSLGG

Chain	Residue	Details
A	VAL75-GLY84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000269\|PubMed:15668381, ECO:0000269\|PubMed:17916738

Chain	Residue	Details
A	SER81
B	SER81
C	SER81
D	SER81
E	SER81
F	SER81
G	SER81
H	SER81

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:15668381

Chain	Residue	Details
A	ASP210
B	ASP210
C	ASP210
D	ASP210
E	ASP210
F	ASP210
G	ASP210
H	ASP210

site_id	SWS_FT_FI3
Number of Residues	8
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:17916738

Chain	Residue	Details
A	HIS238
B	HIS238
C	HIS238
D	HIS238
E	HIS238
F	HIS238
G	HIS238
H	HIS238

site_id	SWS_FT_FI4
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269\|PubMed:15668381, ECO:0007744\|PDB:1Y7I

Chain	Residue	Details
A	ALA13
B	HIS238
B	LEU253
B	HIS257
C	ALA13
C	SER81
C	LYS159
C	HIS238
C	LEU253
C	HIS257
D	ALA13
A	SER81
D	SER81
D	LYS159
D	HIS238
D	LEU253
D	HIS257
E	ALA13
E	SER81
E	LYS159
E	HIS238
E	LEU253
A	LYS159
E	HIS257
F	ALA13
F	SER81
F	LYS159
F	HIS238
F	LEU253
F	HIS257
G	ALA13
G	SER81
G	LYS159
A	HIS238
G	HIS238
G	LEU253
G	HIS257
H	ALA13
H	SER81
H	LYS159
H	HIS238
H	LEU253
H	HIS257
A	LEU253
A	HIS257
B	ALA13
B	SER81
B	LYS159

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)