1Y62

A 2.4 crystal structure of conkunitzin-S1, a novel Kunitz-fold cone snail neurotoxin.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0015459	molecular_function	potassium channel regulator activity
A	0030414	molecular_function	peptidase inhibitor activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0015459	molecular_function	potassium channel regulator activity
B	0030414	molecular_function	peptidase inhibitor activity
B	0035821	biological_process	modulation of process of another organism
B	0090729	molecular_function	toxin activity
B	0099106	molecular_function	ion channel regulator activity
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0015459	molecular_function	potassium channel regulator activity
C	0030414	molecular_function	peptidase inhibitor activity
C	0035821	biological_process	modulation of process of another organism
C	0090729	molecular_function	toxin activity
C	0099106	molecular_function	ion channel regulator activity
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0015459	molecular_function	potassium channel regulator activity
D	0030414	molecular_function	peptidase inhibitor activity
D	0035821	biological_process	modulation of process of another organism
D	0090729	molecular_function	toxin activity
D	0099106	molecular_function	ion channel regulator activity
E	0004867	molecular_function	serine-type endopeptidase inhibitor activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0015459	molecular_function	potassium channel regulator activity
E	0030414	molecular_function	peptidase inhibitor activity
E	0035821	biological_process	modulation of process of another organism
E	0090729	molecular_function	toxin activity
E	0099106	molecular_function	ion channel regulator activity
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0015459	molecular_function	potassium channel regulator activity
F	0030414	molecular_function	peptidase inhibitor activity
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
F	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 101

Chain	Residue
B	LYS18
B	GLU20
B	ARG22
B	ARG48
B	HOH115
D	ARG48

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 102

Chain	Residue
E	GLU20
E	ARG22
E	ARG48
B	PHE47
B	ARG48
B	HOH138

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 103

Chain	Residue
C	GLU20
C	ARG22
C	ARG48
F	PHE47
F	ARG48
F	HOH139

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 104

Chain	Residue
A	ASN46
A	PHE47
A	ARG48
A	HOH114
F	GLU20
F	ARG22
F	ARG48

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 105

Chain	Residue
D	GLU20
D	ARG22
D	ARG48
E	ASN46
E	PHE47
E	ARG48
E	HOH125

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 106

Chain	Residue
A	LYS18
A	GLU20
A	ARG22
A	ARG48
A	HOH122
C	ASN46
C	PHE47
C	ARG48

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 107

Chain	Residue
B	THR17
B	GLN40
B	HOH121
C	PRO4
C	SER5
D	HOH306

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 108

Chain	Residue
A	THR17
A	GLN40
B	THR17
B	HOH121
C	GLU44
D	PRO4
D	SER5
D	HOH306

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 109

Chain	Residue
C	ARG49
C	TYR51
E	THR50
E	SO4100
E	HOH303

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 110

Chain	Residue
A	LYS21
A	ARG34
C	ARG49
C	ARG55
E	ARG34

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 111

Chain	Residue
B	LYS21
B	ARG34
D	ARG49
D	ARG55
D	HOH145
F	ARG34

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 112

Chain	Residue
D	ARG49
D	THR50
D	TYR51
F	THR50
F	HOH116
F	HOH324

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 113

Chain	Residue
A	THR50
B	ARG49
B	THR50
B	TYR51
B	SO499

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 100

Chain	Residue
C	THR50
E	ARG49
E	THR50
E	TYR51
E	SO4109

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 99

Chain	Residue
A	ARG49
A	THR50
A	TYR51
B	ARG49
B	THR50
B	SO4113

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	300
Details	Domain: {"description":"BPTI/Kunitz inhibitor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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