1Y62
A 2.4 crystal structure of conkunitzin-S1, a novel Kunitz-fold cone snail neurotoxin.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0015459 | molecular_function | potassium channel regulator activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0090729 | molecular_function | toxin activity |
| C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0015459 | molecular_function | potassium channel regulator activity |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0090729 | molecular_function | toxin activity |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0015459 | molecular_function | potassium channel regulator activity |
| D | 0035821 | biological_process | modulation of process of another organism |
| D | 0090729 | molecular_function | toxin activity |
| E | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0015459 | molecular_function | potassium channel regulator activity |
| E | 0035821 | biological_process | modulation of process of another organism |
| E | 0090729 | molecular_function | toxin activity |
| F | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005615 | cellular_component | extracellular space |
| F | 0015459 | molecular_function | potassium channel regulator activity |
| F | 0035821 | biological_process | modulation of process of another organism |
| F | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 101 |
| Chain | Residue |
| B | LYS18 |
| B | GLU20 |
| B | ARG22 |
| B | ARG48 |
| B | HOH115 |
| D | ARG48 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 102 |
| Chain | Residue |
| E | GLU20 |
| E | ARG22 |
| E | ARG48 |
| B | PHE47 |
| B | ARG48 |
| B | HOH138 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 103 |
| Chain | Residue |
| C | GLU20 |
| C | ARG22 |
| C | ARG48 |
| F | PHE47 |
| F | ARG48 |
| F | HOH139 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 104 |
| Chain | Residue |
| A | ASN46 |
| A | PHE47 |
| A | ARG48 |
| A | HOH114 |
| F | GLU20 |
| F | ARG22 |
| F | ARG48 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 105 |
| Chain | Residue |
| D | GLU20 |
| D | ARG22 |
| D | ARG48 |
| E | ASN46 |
| E | PHE47 |
| E | ARG48 |
| E | HOH125 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 106 |
| Chain | Residue |
| A | LYS18 |
| A | GLU20 |
| A | ARG22 |
| A | ARG48 |
| A | HOH122 |
| C | ASN46 |
| C | PHE47 |
| C | ARG48 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 107 |
| Chain | Residue |
| B | THR17 |
| B | GLN40 |
| B | HOH121 |
| C | PRO4 |
| C | SER5 |
| D | HOH306 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 108 |
| Chain | Residue |
| A | THR17 |
| A | GLN40 |
| B | THR17 |
| B | HOH121 |
| C | GLU44 |
| D | PRO4 |
| D | SER5 |
| D | HOH306 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 109 |
| Chain | Residue |
| C | ARG49 |
| C | TYR51 |
| E | THR50 |
| E | SO4100 |
| E | HOH303 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 110 |
| Chain | Residue |
| A | LYS21 |
| A | ARG34 |
| C | ARG49 |
| C | ARG55 |
| E | ARG34 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 111 |
| Chain | Residue |
| B | LYS21 |
| B | ARG34 |
| D | ARG49 |
| D | ARG55 |
| D | HOH145 |
| F | ARG34 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 F 112 |
| Chain | Residue |
| D | ARG49 |
| D | THR50 |
| D | TYR51 |
| F | THR50 |
| F | HOH116 |
| F | HOH324 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 113 |
| Chain | Residue |
| A | THR50 |
| B | ARG49 |
| B | THR50 |
| B | TYR51 |
| B | SO499 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 100 |
| Chain | Residue |
| C | THR50 |
| E | ARG49 |
| E | THR50 |
| E | TYR51 |
| E | SO4109 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 99 |
| Chain | Residue |
| A | ARG49 |
| A | THR50 |
| A | TYR51 |
| B | ARG49 |
| B | THR50 |
| B | SO4113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | MOD_RES: Threonine amide => ECO:0000269|PubMed:15833744 |
| Chain | Residue | Details |
| A | THR60 | |
| B | THR60 | |
| C | THR60 | |
| D | THR60 | |
| E | THR60 | |
| F | THR60 |
