1Y60

Structure of the tetrahydromethanopterin dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1 with bound 5,10-methylene tetrahydromethanopterin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006730	biological_process	one-carbon metabolic process
A	0009636	biological_process	response to toxic substance
A	0016051	biological_process	carbohydrate biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016840	molecular_function	carbon-nitrogen lyase activity
A	0046294	biological_process	formaldehyde catabolic process
B	0005737	cellular_component	cytoplasm
B	0006730	biological_process	one-carbon metabolic process
B	0009636	biological_process	response to toxic substance
B	0016051	biological_process	carbohydrate biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016840	molecular_function	carbon-nitrogen lyase activity
B	0046294	biological_process	formaldehyde catabolic process
C	0005737	cellular_component	cytoplasm
C	0006730	biological_process	one-carbon metabolic process
C	0009636	biological_process	response to toxic substance
C	0016051	biological_process	carbohydrate biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016840	molecular_function	carbon-nitrogen lyase activity
C	0046294	biological_process	formaldehyde catabolic process
D	0005737	cellular_component	cytoplasm
D	0006730	biological_process	one-carbon metabolic process
D	0009636	biological_process	response to toxic substance
D	0016051	biological_process	carbohydrate biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016840	molecular_function	carbon-nitrogen lyase activity
D	0046294	biological_process	formaldehyde catabolic process
E	0005737	cellular_component	cytoplasm
E	0006730	biological_process	one-carbon metabolic process
E	0009636	biological_process	response to toxic substance
E	0016051	biological_process	carbohydrate biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016840	molecular_function	carbon-nitrogen lyase activity
E	0046294	biological_process	formaldehyde catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE H4M D 994

Chain	Residue
D	HOH224
E	HOH810
E	LEU4052
E	LEU4053
E	ASP4076
E	ALA4077
E	ALA4080
E	PHE4084
E	GLN4088
D	HOH843
D	HIS3022
D	ASP3024
D	LYS3071
D	VAL3072
D	THR3073
D	ASN3075
D	PHE3119

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE H4M C 995

Chain	Residue
C	HOH483
C	HIS2022
C	ASP2024
C	LYS2071
C	VAL2072
C	THR2073
C	PHE2119
C	PHE2166
D	HIS3047
D	GLY3048
D	THR3050
D	LEU3052
D	LEU3053
D	ASN3075
D	ASP3076
D	ALA3077
D	PHE3084
D	GLN3088

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE H4M E 996

Chain	Residue
A	THR50
A	LEU52
A	LEU53
A	ASP76
A	ALA77
A	PHE84
A	GLN88
A	HOH855
E	HOH260
E	HIS4022
E	ASP4024
E	LYS4071
E	VAL4072
E	THR4073
E	PHE4119

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE H4M B 997

Chain	Residue
B	HOH812
B	HOH815
B	HIS1022
B	ASP1024
B	LYS1071
B	VAL1072
B	THR1073
C	THR2050
C	LEU2052
C	LEU2053
C	ILE2074
C	ASN2075
C	ASP2076
C	ALA2077
C	ALA2080
C	PHE2084
C	GLN2088

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE H4M B 998

Chain	Residue
A	HIS22
A	ASP24
A	LYS71
A	VAL72
A	THR73
A	PHE119
A	HOH388
B	HOH814
B	THR1050
B	LEU1052
B	LEU1053
B	VAL1055
B	ILE1074
B	ASN1075
B	ASP1076
B	ALA1077
B	PHE1084
B	GLN1088

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	Binding site: {}

Chain

Residue

Details

---