1Y4L
Crystal structure of Bothrops asper myotoxin II complexed with the anti-trypanosomal drug suramin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| B | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0050482 | biological_process | arachidonate secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE SVR B 301 |
| Chain | Residue |
| A | LEU2 |
| A | PRO68 |
| A | LYS69 |
| A | LYS70 |
| A | P33401 |
| A | HOH525 |
| B | LEU2 |
| B | LEU5 |
| B | GLY30 |
| B | VAL31 |
| B | ARG34 |
| A | GLY30 |
| B | HIS48 |
| B | LYS49 |
| B | TYR52 |
| B | LYS53 |
| B | LYS69 |
| B | LYS70 |
| B | LYS93 |
| B | P33402 |
| A | VAL31 |
| A | LEU32 |
| A | GLY33 |
| A | ARG34 |
| A | LYS49 |
| A | TYR52 |
| A | LYS53 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE P33 A 401 |
| Chain | Residue |
| A | LEU2 |
| A | GLY6 |
| A | LYS7 |
| A | LEU10 |
| A | PRO17 |
| A | TYR22 |
| A | ASN28 |
| A | CYS29 |
| A | GLY30 |
| A | CYS45 |
| A | HIS48 |
| A | LYS49 |
| B | SVR301 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE P33 B 402 |
| Chain | Residue |
| B | LEU2 |
| B | GLY6 |
| B | LYS7 |
| B | LEU10 |
| B | PRO17 |
| B | TYR22 |
| B | ASN28 |
| B | CYS29 |
| B | GLY30 |
| B | CYS45 |
| B | HIS48 |
| B | LYS49 |
| B | SVR301 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA B 501 |
| Chain | Residue |
| A | HOH550 |
| B | LEU58 |
| B | THR59 |
| B | SER90 |
| B | GLU94 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA B 502 |
| Chain | Residue |
| B | ASN16 |
| B | LYS19 |
| B | SER20 |
| B | IPA505 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA A 503 |
| Chain | Residue |
| A | LYS19 |
| A | LYS115 |
| A | ARG118 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA A 504 |
| Chain | Residue |
| A | ASN16 |
| A | LYS19 |
| A | HOH582 |
| A | HOH602 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA B 505 |
| Chain | Residue |
| B | LYS19 |
| B | LYS115 |
| B | ARG118 |
| B | IPA502 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Important for membrane-damaging activities in eukaryotes and bacteria; heparin-binding","evidences":[{"source":"PubMed","id":"21506137","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7961981","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9654096","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important residue of the cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Hydrophobic membrane-disruption site (MDiS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| A | HIS48 | |
| A | GLY30 | |
| A | ASP99 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| B | HIS48 | |
| B | GLY30 | |
| B | ASP99 |
