1Y2M
Crystal structure of phenylalanine ammonia-lyase from yeast Rhododporidium toruloides
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0009698 | biological_process | phenylpropanoid metabolic process |
| A | 0009800 | biological_process | cinnamic acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016841 | molecular_function | ammonia-lyase activity |
| A | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
| A | 0052883 | molecular_function | tyrosine ammonia-lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006559 | biological_process | L-phenylalanine catabolic process |
| B | 0009698 | biological_process | phenylpropanoid metabolic process |
| B | 0009800 | biological_process | cinnamic acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016841 | molecular_function | ammonia-lyase activity |
| B | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
| B | 0052883 | molecular_function | tyrosine ammonia-lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006559 | biological_process | L-phenylalanine catabolic process |
| C | 0009698 | biological_process | phenylpropanoid metabolic process |
| C | 0009800 | biological_process | cinnamic acid biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016841 | molecular_function | ammonia-lyase activity |
| C | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
| C | 0052883 | molecular_function | tyrosine ammonia-lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006559 | biological_process | L-phenylalanine catabolic process |
| D | 0009698 | biological_process | phenylpropanoid metabolic process |
| D | 0009800 | biological_process | cinnamic acid biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016841 | molecular_function | ammonia-lyase activity |
| D | 0045548 | molecular_function | phenylalanine ammonia-lyase activity |
| D | 0052883 | molecular_function | tyrosine ammonia-lyase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00488 |
| Number of Residues | 17 |
| Details | PAL_HISTIDASE Phenylalanine and histidine ammonia-lyases signature. GTISASGDLsPLSyiaA |
| Chain | Residue | Details |
| A | GLY207-ALA223 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q68G84 |
| Chain | Residue | Details |
| A | TYR110 | |
| B | TYR110 | |
| C | TYR110 | |
| D | TYR110 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q68G84 |
| Chain | Residue | Details |
| A | ASN270 | |
| B | ASN499 | |
| C | ASN270 | |
| C | GLN360 | |
| C | ARG366 | |
| C | ASN397 | |
| C | ASN499 | |
| D | ASN270 | |
| D | GLN360 | |
| D | ARG366 | |
| D | ASN397 | |
| A | GLN360 | |
| D | ASN499 | |
| A | ARG366 | |
| A | ASN397 | |
| A | ASN499 | |
| B | ASN270 | |
| B | GLN360 | |
| B | ARG366 | |
| B | ASN397 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15350127, ECO:0007744|PDB:1T6J |
| Chain | Residue | Details |
| A | LYS468 | |
| A | GLU496 | |
| B | LYS468 | |
| B | GLU496 | |
| C | LYS468 | |
| C | GLU496 | |
| D | LYS468 | |
| D | GLU496 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: 2,3-didehydroalanine (Ser) => ECO:0000269|PubMed:15350127 |
| Chain | Residue | Details |
| A | SER212 | |
| B | SER212 | |
| C | SER212 | |
| D | SER212 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CROSSLNK: 5-imidazolinone (Ala-Gly) => ECO:0000269|PubMed:15350127 |
| Chain | Residue | Details |
| A | ALA211 | |
| A | GLY213 | |
| B | ALA211 | |
| B | GLY213 | |
| C | ALA211 | |
| C | GLY213 | |
| D | ALA211 | |
| D | GLY213 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1b8f |
| Chain | Residue | Details |
| A | SER212 | |
| A | GLN500 | |
| A | ALA211 | |
| A | GLY213 | |
| A | TYR363 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1b8f |
| Chain | Residue | Details |
| B | SER212 | |
| B | GLN500 | |
| B | ALA211 | |
| B | GLY213 | |
| B | TYR363 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1b8f |
| Chain | Residue | Details |
| C | SER212 | |
| C | GLN500 | |
| C | ALA211 | |
| C | GLY213 | |
| C | TYR363 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1b8f |
| Chain | Residue | Details |
| D | SER212 | |
| D | GLN500 | |
| D | ALA211 | |
| D | GLY213 | |
| D | TYR363 |
