1Y25

structure of mycobacterial thiol peroxidase Tpx

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0015036	molecular_function	disulfide oxidoreductase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
A	0045454	biological_process	cell redox homeostasis
A	0051409	biological_process	response to nitrosative stress
A	0051920	molecular_function	peroxiredoxin activity
A	0098754	biological_process	detoxification
A	0098869	biological_process	cellular oxidant detoxification
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0003824	molecular_function	catalytic activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0015036	molecular_function	disulfide oxidoreductase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
B	0045454	biological_process	cell redox homeostasis
B	0051409	biological_process	response to nitrosative stress
B	0051920	molecular_function	peroxiredoxin activity
B	0098754	biological_process	detoxification
B	0098869	biological_process	cellular oxidant detoxification
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 1200

Chain	Residue
A	THR57
A	PRO58
A	VAL59
A	SER60
A	ARG130

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT B 2200

Chain	Residue
B	ARG130
B	HOH2298
B	THR57
B	PRO58
B	VAL59
B	SER60

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Functional Information from PROSITE/UniProt

site_id	PS01265
Number of Residues	12
Details	TPX Tpx family signature. SkDLPFAqkRFC

Chain	Residue	Details
A	SER82-CYS93

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000250|UniProtKB:P0A862, ECO:0000255|HAMAP-Rule:MF_00269, ECO:0000305|PubMed:16884737

Chain	Residue	Details
A	SER60
B	SER60

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