1Y1M

Crystal structure of the NR1 ligand binding core in complex with cycloleucine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AC5 A 1001

Chain	Residue
A	PHE92
A	HOH1018
A	PRO124
A	LEU125
A	THR126
A	ARG131
A	SER180
A	TRP223
A	ASP224
A	PHE250

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AC5 B 1002

Chain	Residue
B	PHE92
B	PRO124
B	LEU125
B	THR126
B	ARG131
B	SER180
B	TRP223
B	ASP224
B	PHE250
B	HOH1011

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28468946","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2017","submissionDatabase":"PDB data bank","title":"Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC.","authors":["Mou T.C.","Sprang S.R.","Hansen K.B."]}},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12805203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28468946","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2017","submissionDatabase":"PDB data bank","title":"Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC.","authors":["Mou T.C.","Sprang S.R.","Hansen K.B."]}},{"source":"PDB","id":"1PB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12805203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28468946","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2017","submissionDatabase":"PDB data bank","title":"Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC.","authors":["Mou T.C.","Sprang S.R.","Hansen K.B."]}},{"source":"PDB","id":"1PB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---