1Y10

Mycobacterial adenylyl cyclase Rv1264, holoenzyme, inhibited state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004016	molecular_function	adenylate cyclase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006171	biological_process	cAMP biosynthetic process
A	0008289	molecular_function	lipid binding
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0009268	biological_process	response to pH
A	0010855	molecular_function	adenylate cyclase inhibitor activity
A	0016829	molecular_function	lyase activity
A	0030145	molecular_function	manganese ion binding
A	0035556	biological_process	intracellular signal transduction
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004016	molecular_function	adenylate cyclase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006171	biological_process	cAMP biosynthetic process
B	0008289	molecular_function	lipid binding
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0009268	biological_process	response to pH
B	0010855	molecular_function	adenylate cyclase inhibitor activity
B	0016829	molecular_function	lyase activity
B	0030145	molecular_function	manganese ion binding
B	0035556	biological_process	intracellular signal transduction
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0004016	molecular_function	adenylate cyclase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006171	biological_process	cAMP biosynthetic process
C	0008289	molecular_function	lipid binding
C	0009190	biological_process	cyclic nucleotide biosynthetic process
C	0009268	biological_process	response to pH
C	0010855	molecular_function	adenylate cyclase inhibitor activity
C	0016829	molecular_function	lyase activity
C	0030145	molecular_function	manganese ion binding
C	0035556	biological_process	intracellular signal transduction
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004016	molecular_function	adenylate cyclase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006171	biological_process	cAMP biosynthetic process
D	0008289	molecular_function	lipid binding
D	0009190	biological_process	cyclic nucleotide biosynthetic process
D	0009268	biological_process	response to pH
D	0010855	molecular_function	adenylate cyclase inhibitor activity
D	0016829	molecular_function	lyase activity
D	0030145	molecular_function	manganese ion binding
D	0035556	biological_process	intracellular signal transduction
D	0042803	molecular_function	protein homodimerization activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 604

Chain	Residue
C	ASP265
C	HOH690
D	GLU136

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 605

Chain	Residue
D	ASP222
D	LEU223
D	ASP265

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 606

Chain	Residue
B	ASP265
A	HOH673
B	ASP222
B	LEU223

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 607

Chain	Residue
A	ASP222
A	LEU223
A	ASP265
A	ARG298
A	HOH669

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 608

Chain	Residue
A	GLU136
A	HOH673
B	ASP222
B	ASP265
B	HOH661

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 609

Chain	Residue
A	GLU44
A	HOH624
A	HOH653
D	GLU44

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA D 610

Chain	Residue
C	HOH708
D	GLU195

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA D 611

Chain	Residue
D	ASN319

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE A 601

Chain	Residue
A	LEU53
A	MET154
B	PHE117
B	VAL130

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE B 602

Chain	Residue
A	MET193
B	MET145
B	SER167
B	HOH706

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE D 603

Chain	Residue
C	PHE117
C	VAL130
C	MET193
D	ALA149
D	LEU150
D	HOH730

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	324
Details	Domain: {"description":"Guanylate cyclase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Region: {"description":"Linker"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11839758","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ab8

Chain	Residue	Details
A	ARG323

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ab8

Chain	Residue	Details
B	ARG323

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ab8

Chain	Residue	Details
C	ARG323

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ab8

Chain	Residue	Details
D	ARG323

---