Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| B | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0050482 | biological_process | arachidonate secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | LYS116 |
| A | TYR117 |
| B | LYS116 |
| B | TYR117 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 303 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 304 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 305 |
| Chain | Residue |
| A | GLY33 |
| A | ARG34 |
| A | LYS53 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE STE A 201 |
| Chain | Residue |
| A | LEU2 |
| A | PHE3 |
| A | PRO18 |
| A | ASN28 |
| A | CYS29 |
| A | GLY30 |
| A | CYS45 |
| A | HIS48 |
| A | LYS49 |
| A | STE202 |
| B | PRO125 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE STE A 202 |
| Chain | Residue |
| A | GLY30 |
| A | VAL31 |
| A | LYS49 |
| A | TYR52 |
| A | LYS69 |
| A | STE201 |
| B | ALA19 |
| B | GLY23 |
| B | VAL31 |
| B | STE204 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE STE B 203 |
| Chain | Residue |
| A | TYR121 |
| B | TYR22 |
| B | ASN28 |
| B | CYS29 |
| B | GLY30 |
| B | CYS45 |
| B | HIS48 |
| B | LYS49 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE STE B 204 |
| Chain | Residue |
| A | STE202 |
| B | LEU2 |
| B | GLY30 |
| B | LYS49 |
| B | TYR52 |
| B | LYS69 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE STE A 205 |
| Chain | Residue |
| A | LYS7 |
| A | LEU10 |
| A | GLN11 |
| A | TYR75 |
| A | TRP77 |
| B | GLN11 |
| B | GLY15 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE STE B 206 |
| Chain | Residue |
| A | LEU10 |
| A | GLN11 |
| A | GLY15 |
| B | PHE3 |
| B | LYS7 |
| B | LEU10 |
| B | GLN11 |
| B | TYR75 |
| B | TRP77 |
Functional Information from PROSITE/UniProt
| site_id | PS00118 |
| Number of Residues | 8 |
| Details | PA2_HIS Phospholipase A2 histidine active site. CCYvHKcC |
| Chain | Residue | Details |
| A | CYS44-CYS51 | |
| site_id | PS00119 |
| Number of Residues | 11 |
| Details | PA2_ASP Phospholipase A2 aspartic acid active site. LCECDKAVaIC |
| Chain | Residue | Details |
| A | LEU95-CYS105 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Region: {"description":"Important for membrane-damaging activities in eukaryotes and bacteria; heparin-binding","evidences":[{"source":"UniProtKB","id":"P24605","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cationic membrane-docking site (MDoS)","evidences":[{"source":"PubMed","id":"29287778","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important residue of the cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"29287778","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Hydrophobic membrane-disruption site (MDiS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| A | HIS48 | |
| A | GLY30 | |
| A | ASP99 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| B | HIS48 | |
| B | GLY30 | |
| B | ASP99 | |
1XXS
