1XWW

Crystal Structure of Human B-form Low Molecular Weight Phosphotyrosyl Phosphatase at 1.6 Angstrom Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003993	molecular_function	acid phosphatase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0004726	molecular_function	non-membrane spanning protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006470	biological_process	protein dephosphorylation
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0016791	molecular_function	phosphatase activity
A	0042383	cellular_component	sarcolemma
A	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	CYS12
A	LEU13
A	GLY14
A	ASN15
A	ILE16
A	CYS17
A	ARG18
A	ASP129

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 202

Chain	Residue
A	TYR142
A	ARG150
A	HOH221
A	HOH319
A	HOH322
A	LEU29

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P11064

Chain	Residue	Details
A	CYS12

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P11064

Chain	Residue	Details
A	ARG18

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P11064

Chain	Residue	Details
A	ASP129

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1939112

Chain	Residue	Details
A	ALA1

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:9038134

Chain	Residue	Details
A	TYR131
A	TYR132

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pnt

Chain	Residue	Details
A	CYS17
A	ARG18
A	ASP129
A	CYS12

---