1XWK

2.3 angstrom resolution crystal structure of human glutathione S-transferase M1A-1A complexed with glutathionyl-S-dinitrobenzene

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0016740	molecular_function	transferase activity
A	0018916	biological_process	nitrobenzene metabolic process
A	0019899	molecular_function	enzyme binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043295	molecular_function	glutathione binding
A	0045171	cellular_component	intercellular bridge
A	0051122	biological_process	hepoxilin biosynthetic process
A	0070458	biological_process	cellular detoxification of nitrogen compound
A	1901687	biological_process	glutathione derivative biosynthetic process
B	0004364	molecular_function	glutathione transferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0016740	molecular_function	transferase activity
B	0018916	biological_process	nitrobenzene metabolic process
B	0019899	molecular_function	enzyme binding
B	0042178	biological_process	xenobiotic catabolic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043295	molecular_function	glutathione binding
B	0045171	cellular_component	intercellular bridge
B	0051122	biological_process	hepoxilin biosynthetic process
B	0070458	biological_process	cellular detoxification of nitrogen compound
B	1901687	biological_process	glutathione derivative biosynthetic process
C	0004364	molecular_function	glutathione transferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0016740	molecular_function	transferase activity
C	0018916	biological_process	nitrobenzene metabolic process
C	0019899	molecular_function	enzyme binding
C	0042178	biological_process	xenobiotic catabolic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043295	molecular_function	glutathione binding
C	0045171	cellular_component	intercellular bridge
C	0051122	biological_process	hepoxilin biosynthetic process
C	0070458	biological_process	cellular detoxification of nitrogen compound
C	1901687	biological_process	glutathione derivative biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDN A 218

Chain	Residue
A	TRP7
A	MET104
A	HIS107
A	MET108
A	GLY111
A	TYR115
A	HOH224
A	HOH236
C	ASP105
A	LEU12
A	ARG42
A	TRP45
A	LYS49
A	ASN58
A	LEU59
A	GLN71
A	SER72

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDN B 219

Chain	Residue
B	TRP7
B	LEU12
B	ARG42
B	TRP45
B	LYS49
B	ASN58
B	LEU59
B	PRO60
B	GLN71
B	SER72
B	MET104
B	ASP105
B	HIS107
B	MET108
B	GLY111
B	TYR115
B	HOH264

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDN C 220

Chain	Residue
A	ASP105
C	TRP7
C	LEU12
C	TRP45
C	LYS49
C	ASN58
C	LEU59
C	GLN71
C	SER72
C	MET104
C	HIS107
C	MET108
C	GLY111
C	TYR115
C	HOH265
C	HOH266
C	HOH274

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|Ref.20, ECO:0000305|PubMed:16548513

Chain	Residue	Details
A	TRP7
B	SER72
C	TRP7
C	SER43
C	PHE50
C	LEU59
C	SER72
A	SER43
A	PHE50
A	LEU59
A	SER72
B	TRP7
B	SER43
B	PHE50
B	LEU59

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ASN116
B	ASN116
C	ASN116

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10649

Chain	Residue	Details
A	MET34
B	MET34
C	MET34

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04905

Chain	Residue	Details
A	LYS210
B	LYS210
C	LYS210

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