1XWA
Drospohila thioredoxin, oxidized, P41212
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008340 | biological_process | determination of adult lifespan |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0015036 | molecular_function | disulfide oxidoreductase activity |
| A | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0005634 | cellular_component | nucleus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008340 | biological_process | determination of adult lifespan |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| B | 0045454 | biological_process | cell redox homeostasis |
| C | 0005634 | cellular_component | nucleus |
| C | 0005829 | cellular_component | cytosol |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0008340 | biological_process | determination of adult lifespan |
| C | 0015035 | molecular_function | protein-disulfide reductase activity |
| C | 0015036 | molecular_function | disulfide oxidoreductase activity |
| C | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| C | 0045454 | biological_process | cell redox homeostasis |
| D | 0005634 | cellular_component | nucleus |
| D | 0005829 | cellular_component | cytosol |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0008340 | biological_process | determination of adult lifespan |
| D | 0015035 | molecular_function | protein-disulfide reductase activity |
| D | 0015036 | molecular_function | disulfide oxidoreductase activity |
| D | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| D | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD A 801 |
| Chain | Residue |
| A | GLU99 |
| A | CL901 |
| A | HOH904 |
| A | HOH905 |
| B | GLU44 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD A 802 |
| Chain | Residue |
| B | GLU99 |
| A | GLU44 |
| A | CL901 |
| A | HOH902 |
| A | HOH903 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD A 803 |
| Chain | Residue |
| A | THR30 |
| A | ASP61 |
| A | HOH906 |
| A | HOH907 |
| A | HOH908 |
| C | GLU64 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CL A 901 |
| Chain | Residue |
| A | LYS41 |
| A | GLU44 |
| A | GLU99 |
| A | CD801 |
| A | CD802 |
| B | LYS41 |
| B | GLU44 |
| B | GLU99 |
Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VLdFFatWCGPCKmIspkL |
| Chain | Residue | Details |
| A | VAL24-LEU42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 420 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"Q9BRA2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Site: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | PRO34 | |
| A | CYS35 | |
| A | CYS32 | |
| A | GLY33 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| B | PRO34 | |
| B | CYS35 | |
| B | CYS32 | |
| B | GLY33 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| C | PRO34 | |
| C | CYS35 | |
| C | CYS32 | |
| C | GLY33 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| D | PRO34 | |
| D | CYS35 | |
| D | CYS32 | |
| D | GLY33 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | CYS35 | |
| A | CYS32 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| B | CYS35 | |
| B | CYS32 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| C | CYS35 | |
| C | CYS32 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| D | CYS35 | |
| D | CYS32 |
