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1XW6

1.9 angstrom resolution structure of human glutathione S-transferase M1A-1A complexed with glutathione

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0006749biological_processglutathione metabolic process
A0016740molecular_functiontransferase activity
A0018916biological_processnitrobenzene metabolic process
A0019899molecular_functionenzyme binding
A0042178biological_processxenobiotic catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043295molecular_functionglutathione binding
A0045171cellular_componentintercellular bridge
A0051122biological_processhepoxilin biosynthetic process
A0070458biological_processcellular detoxification of nitrogen compound
A1901687biological_processglutathione derivative biosynthetic process
B0004364molecular_functionglutathione transferase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006693biological_processprostaglandin metabolic process
B0006749biological_processglutathione metabolic process
B0016740molecular_functiontransferase activity
B0018916biological_processnitrobenzene metabolic process
B0019899molecular_functionenzyme binding
B0042178biological_processxenobiotic catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043295molecular_functionglutathione binding
B0045171cellular_componentintercellular bridge
B0051122biological_processhepoxilin biosynthetic process
B0070458biological_processcellular detoxification of nitrogen compound
B1901687biological_processglutathione derivative biosynthetic process
C0004364molecular_functionglutathione transferase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006693biological_processprostaglandin metabolic process
C0006749biological_processglutathione metabolic process
C0016740molecular_functiontransferase activity
C0018916biological_processnitrobenzene metabolic process
C0019899molecular_functionenzyme binding
C0042178biological_processxenobiotic catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043295molecular_functionglutathione binding
C0045171cellular_componentintercellular bridge
C0051122biological_processhepoxilin biosynthetic process
C0070458biological_processcellular detoxification of nitrogen compound
C1901687biological_processglutathione derivative biosynthetic process
D0004364molecular_functionglutathione transferase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006693biological_processprostaglandin metabolic process
D0006749biological_processglutathione metabolic process
D0016740molecular_functiontransferase activity
D0018916biological_processnitrobenzene metabolic process
D0019899molecular_functionenzyme binding
D0042178biological_processxenobiotic catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043295molecular_functionglutathione binding
D0045171cellular_componentintercellular bridge
D0051122biological_processhepoxilin biosynthetic process
D0070458biological_processcellular detoxification of nitrogen compound
D1901687biological_processglutathione derivative biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GSH A 750
ChainResidue
ATYR6
ASER72
AMET104
AHOH764
AHOH790
AHOH807
AHOH822
AHOH886
AHOH938
BASP105
ATRP7
ALEU12
AARG42
ATRP45
ALYS49
AASN58
ALEU59
AGLN71

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE GSH B 751
ChainResidue
AASP105
BTYR6
BTRP7
BLEU12
BARG42
BTRP45
BLYS49
BASN58
BLEU59
BPRO60
BGLN71
BSER72
BHOH755
BHOH756
BHOH927

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GSH C 752
ChainResidue
CTYR6
CTRP7
CARG42
CTRP45
CLYS49
CASN58
CLEU59
CGLN71
CSER72
CHOH770
CHOH771
CHOH829
CHOH834
CHOH885
CHOH887
DASP105

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE GSH D 753
ChainResidue
CASP105
DTYR6
DTRP7
DLEU12
DARG42
DTRP45
DLYS49
DASN58
DLEU59
DGLN71
DSER72
DMET104
DHOH766
DHOH767
DHOH818
DHOH872
DHOH886

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|Ref.20, ECO:0000305|PubMed:16548513
ChainResidueDetails
ASER72
BTRP7
BSER43
BPHE50
BLEU59
BSER72
CTRP7
CSER43
CPHE50
CLEU59
CSER72
DTRP7
DSER43
DPHE50
DLEU59
DSER72
ATRP7
ASER43
APHE50
ALEU59

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AASN116
BASN116
CASN116
DASN116

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10649
ChainResidueDetails
AMET34
BMET34
CMET34
DMET34

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04905
ChainResidueDetails
ALYS210
BLYS210
CLYS210
DLYS210

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 867
ChainResidueDetails
ATYR6electrostatic stabiliser, hydrogen bond donor
AARG42electrostatic stabiliser, transition state stabiliser
AHIS107proton acceptor, proton donor

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PDB entries from 2024-06-12

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