1XTR

Structure of small GTPase human Rheb in complex with GppNHp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005681	cellular_component	spliceosomal complex
A	0005765	cellular_component	lysosomal membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0012505	cellular_component	endomembrane system
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0016241	biological_process	regulation of macroautophagy
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019901	molecular_function	protein kinase binding
A	0030295	molecular_function	protein kinase activator activity
A	0031669	biological_process	cellular response to nutrient levels
A	0032006	biological_process	regulation of TOR signaling
A	0032008	biological_process	positive regulation of TOR signaling
A	0043539	molecular_function	protein serine/threonine kinase activator activity
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0051726	biological_process	regulation of cell cycle
A	0070062	cellular_component	extracellular exosome
A	0120163	biological_process	negative regulation of cold-induced thermogenesis
A	1904263	biological_process	positive regulation of TORC1 signaling
A	2000074	biological_process	regulation of type B pancreatic cell development

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 178

Chain	Residue
A	SER20
A	THR38
A	ASP60
A	GNP179
A	HOH181
A	HOH182

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GNP A 179

Chain	Residue
A	GLY18
A	LYS19
A	SER20
A	SER21
A	PHE31
A	VAL32
A	ASP33
A	TYR35
A	THR38
A	GLY63
A	ASN119
A	LYS120
A	ASP122
A	LEU123
A	SER149
A	ALA150
A	MG178
A	HOH182
A	HOH186
A	ARG15
A	SER16
A	VAL17

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 180

Chain	Residue
A	ALA62
A	GLY63
A	GLN64
A	ILE69
A	PRO71

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15728574","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15728574","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22002721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22819219","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32470140","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XTQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BTC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15728574","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22002721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15728574","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29416044","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5YXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BSX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BT0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15728574","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XTS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15728574","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22002721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22819219","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29416044","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32470140","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BT0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BTC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15728574","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Important for autoinhibition of GTPase activity","evidences":[{"source":"PubMed","id":"22819219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by MAPKAPK5","evidences":[{"source":"UniProtKB","id":"Q921J2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30514904","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN64

---