1XTQ
Structure of small GTPase human Rheb in complex with GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005681 | cellular_component | spliceosomal complex |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0016020 | cellular_component | membrane |
| A | 0016241 | biological_process | regulation of macroautophagy |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019003 | molecular_function | GDP binding |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030295 | molecular_function | protein kinase activator activity |
| A | 0031669 | biological_process | cellular response to nutrient levels |
| A | 0032006 | biological_process | regulation of TOR signaling |
| A | 0032008 | biological_process | positive regulation of TOR signaling |
| A | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048709 | biological_process | oligodendrocyte differentiation |
| A | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| A | 2000074 | biological_process | regulation of type B pancreatic cell development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | SER20 |
| A | GDP201 |
| A | HOH203 |
| A | HOH204 |
| A | HOH205 |
| A | HOH206 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDP A 201 |
| Chain | Residue |
| A | LYS19 |
| A | SER20 |
| A | SER21 |
| A | PHE31 |
| A | ASN119 |
| A | LYS120 |
| A | ASP122 |
| A | LEU123 |
| A | SER149 |
| A | ALA150 |
| A | LYS151 |
| A | MG202 |
| A | HOH203 |
| A | HOH204 |
| A | HOH208 |
| A | HOH268 |
| A | HOH325 |
| A | HOH331 |
| A | HOH343 |
| A | HOH355 |
| A | SER16 |
| A | VAL17 |
| A | GLY18 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:29236692, ECO:0007744|PDB:1XTS, ECO:0007744|PDB:6BCU |
| Chain | Residue | Details |
| A | SER16 | |
| A | GLY18 | |
| A | TYR35 | |
| A | ASN119 | |
| A | ASP122 | |
| A | ALA150 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:32470140, ECO:0007744|PDB:1XTQ, ECO:0007744|PDB:3SEA, ECO:0007744|PDB:3T5G, ECO:0007744|PDB:7BTA, ECO:0007744|PDB:7BTC |
| Chain | Residue | Details |
| A | VAL17 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:29236692, ECO:0007744|PDB:1XTS, ECO:0007744|PDB:6BCU |
| Chain | Residue | Details |
| A | LYS19 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0007744|PDB:5YXH, ECO:0007744|PDB:6BCU, ECO:0007744|PDB:6BSX, ECO:0007744|PDB:6BT0 |
| Chain | Residue | Details |
| A | SER20 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0007744|PDB:1XTS |
| Chain | Residue | Details |
| A | SER21 | |
| A | VAL32 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0007744|PDB:3SEA, ECO:0007744|PDB:6BT0, ECO:0007744|PDB:7BTA, ECO:0007744|PDB:7BTC |
| Chain | Residue | Details |
| A | ASP33 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:29236692, ECO:0007744|PDB:6BCU |
| Chain | Residue | Details |
| A | THR38 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Important for autoinhibition of GTPase activity => ECO:0000269|PubMed:22819219 |
| Chain | Residue | Details |
| A | TYR35 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000250|UniProtKB:Q921J2 |
| Chain | Residue | Details |
| A | SER130 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:30514904 |
| Chain | Residue | Details |
| A | LYS8 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN64 |
