1XTC

CHOLERA TOXIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005615	cellular_component	extracellular space
A	0090729	molecular_function	toxin activity
C	0005615	cellular_component	extracellular space
C	0090729	molecular_function	toxin activity
D	0005515	molecular_function	protein binding
D	0005534	molecular_function	galactose binding
D	0005576	cellular_component	extracellular region
D	0016020	cellular_component	membrane
D	0020002	cellular_component	host cell plasma membrane
D	0035821	biological_process	modulation of process of another organism
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0042597	cellular_component	periplasmic space
D	0046812	molecular_function	host cell surface binding
D	0090729	molecular_function	toxin activity
D	1902494	cellular_component	catalytic complex
E	0005515	molecular_function	protein binding
E	0005534	molecular_function	galactose binding
E	0005576	cellular_component	extracellular region
E	0016020	cellular_component	membrane
E	0020002	cellular_component	host cell plasma membrane
E	0035821	biological_process	modulation of process of another organism
E	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
E	0042597	cellular_component	periplasmic space
E	0046812	molecular_function	host cell surface binding
E	0090729	molecular_function	toxin activity
E	1902494	cellular_component	catalytic complex
F	0005515	molecular_function	protein binding
F	0005534	molecular_function	galactose binding
F	0005576	cellular_component	extracellular region
F	0016020	cellular_component	membrane
F	0020002	cellular_component	host cell plasma membrane
F	0035821	biological_process	modulation of process of another organism
F	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
F	0042597	cellular_component	periplasmic space
F	0046812	molecular_function	host cell surface binding
F	0090729	molecular_function	toxin activity
F	1902494	cellular_component	catalytic complex
G	0005515	molecular_function	protein binding
G	0005534	molecular_function	galactose binding
G	0005576	cellular_component	extracellular region
G	0016020	cellular_component	membrane
G	0020002	cellular_component	host cell plasma membrane
G	0035821	biological_process	modulation of process of another organism
G	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
G	0042597	cellular_component	periplasmic space
G	0046812	molecular_function	host cell surface binding
G	0090729	molecular_function	toxin activity
G	1902494	cellular_component	catalytic complex
H	0005515	molecular_function	protein binding
H	0005534	molecular_function	galactose binding
H	0005576	cellular_component	extracellular region
H	0016020	cellular_component	membrane
H	0020002	cellular_component	host cell plasma membrane
H	0035821	biological_process	modulation of process of another organism
H	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
H	0042597	cellular_component	periplasmic space
H	0046812	molecular_function	host cell surface binding
H	0090729	molecular_function	toxin activity
H	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	CAT
Number of Residues	3
Details	CATALYTIC SITE

Chain	Residue
A	ARG7
A	SER61
A	GLU112

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site_id	GAD
Number of Residues	7
Details	GANGLIOSIDE BINDING SITE IN CHAIN D

Chain	Residue
D	LYS91
D	ALA46
D	GLU51
D	GLN56
D	GLN61
D	TRP88
D	ASN90

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site_id	GAE
Number of Residues	7
Details	GANGLIOSIDE BINDING SITE IN CHAIN E

Chain	Residue
E	ALA46
E	GLU51
E	GLN56
E	GLN61
E	TRP88
E	ASN90
E	LYS91

---

site_id	GAF
Number of Residues	7
Details	GANGLIOSIDE BINDING SITE IN CHAIN F

Chain	Residue
F	ALA46
F	GLU51
F	GLN56
F	GLN61
F	TRP88
F	ASN90
F	LYS91

---

site_id	GAG
Number of Residues	7
Details	GANGLIOSIDE BINDING SITE IN CHAIN G

Chain	Residue
G	ALA46
G	GLU51
G	GLN56
G	GLN61
G	TRP88
G	ASN90
G	LYS91

---

site_id	GAH
Number of Residues	7
Details	GANGLIOSIDE BINDING SITE IN CHAIN H

Chain	Residue
H	ALA46
H	GLU51
H	GLN56
H	GLN61
H	TRP88
H	ASN90
H	LYS91

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Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. KDEL

Chain	Residue	Details
C	LYS237-LEU240

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	GLU112

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:16099990

Chain	Residue	Details
A	ARG7
A	MET23

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 7658473

Chain	Residue	Details
A	SER61
A	ARG7
A	GLU112
A	GLU110

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site_id	MCSA1
Number of Residues
Details	M-CSA 919

Chain	Residue	Details
A	ARG7	electrostatic stabiliser
A	SER61	electrostatic stabiliser
A	GLU110	proton shuttle (general acid/base)
A	GLU112	electrostatic stabiliser

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