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1XTC

CHOLERA TOXIN

Functional Information from GO Data
ChainGOidnamespacecontents
A0005615cellular_componentextracellular space
A0090729molecular_functiontoxin activity
C0005615cellular_componentextracellular space
C0090729molecular_functiontoxin activity
D0005515molecular_functionprotein binding
D0005534molecular_functiongalactose binding
D0005576cellular_componentextracellular region
D0016020cellular_componentmembrane
D0020002cellular_componenthost cell plasma membrane
D0035821biological_processmodulation of process of another organism
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0042597cellular_componentperiplasmic space
D0046812molecular_functionhost cell surface binding
D0090729molecular_functiontoxin activity
D1902494cellular_componentcatalytic complex
E0005515molecular_functionprotein binding
E0005534molecular_functiongalactose binding
E0005576cellular_componentextracellular region
E0016020cellular_componentmembrane
E0020002cellular_componenthost cell plasma membrane
E0035821biological_processmodulation of process of another organism
E0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
E0042597cellular_componentperiplasmic space
E0046812molecular_functionhost cell surface binding
E0090729molecular_functiontoxin activity
E1902494cellular_componentcatalytic complex
F0005515molecular_functionprotein binding
F0005534molecular_functiongalactose binding
F0005576cellular_componentextracellular region
F0016020cellular_componentmembrane
F0020002cellular_componenthost cell plasma membrane
F0035821biological_processmodulation of process of another organism
F0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
F0042597cellular_componentperiplasmic space
F0046812molecular_functionhost cell surface binding
F0090729molecular_functiontoxin activity
F1902494cellular_componentcatalytic complex
G0005515molecular_functionprotein binding
G0005534molecular_functiongalactose binding
G0005576cellular_componentextracellular region
G0016020cellular_componentmembrane
G0020002cellular_componenthost cell plasma membrane
G0035821biological_processmodulation of process of another organism
G0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
G0042597cellular_componentperiplasmic space
G0046812molecular_functionhost cell surface binding
G0090729molecular_functiontoxin activity
G1902494cellular_componentcatalytic complex
H0005515molecular_functionprotein binding
H0005534molecular_functiongalactose binding
H0005576cellular_componentextracellular region
H0016020cellular_componentmembrane
H0020002cellular_componenthost cell plasma membrane
H0035821biological_processmodulation of process of another organism
H0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
H0042597cellular_componentperiplasmic space
H0046812molecular_functionhost cell surface binding
H0090729molecular_functiontoxin activity
H1902494cellular_componentcatalytic complex
Functional Information from PDB Data
site_idCAT
Number of Residues3
DetailsCATALYTIC SITE
ChainResidue
AARG7
ASER61
AGLU112

site_idGAD
Number of Residues7
DetailsGANGLIOSIDE BINDING SITE IN CHAIN D
ChainResidue
DLYS91
DALA46
DGLU51
DGLN56
DGLN61
DTRP88
DASN90

site_idGAE
Number of Residues7
DetailsGANGLIOSIDE BINDING SITE IN CHAIN E
ChainResidue
EALA46
EGLU51
EGLN56
EGLN61
ETRP88
EASN90
ELYS91

site_idGAF
Number of Residues7
DetailsGANGLIOSIDE BINDING SITE IN CHAIN F
ChainResidue
FALA46
FGLU51
FGLN56
FGLN61
FTRP88
FASN90
FLYS91

site_idGAG
Number of Residues7
DetailsGANGLIOSIDE BINDING SITE IN CHAIN G
ChainResidue
GALA46
GGLU51
GGLN56
GGLN61
GTRP88
GASN90
GLYS91

site_idGAH
Number of Residues7
DetailsGANGLIOSIDE BINDING SITE IN CHAIN H
ChainResidue
HALA46
HGLU51
HGLN56
HGLN61
HTRP88
HASN90
HLYS91

Functional Information from PROSITE/UniProt
site_idPS00014
Number of Residues4
DetailsER_TARGET Endoplasmic reticulum targeting sequence. KDEL
ChainResidueDetails
CLYS237-LEU240

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AGLU112

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:16099990
ChainResidueDetails
AARG7
AMET23

Catalytic Information from CSA
site_idCSA1
Number of Residues4
Detailsa catalytic site defined by CSA, PubMed 7658473
ChainResidueDetails
ASER61
AARG7
AGLU112
AGLU110

site_idMCSA1
Number of Residues
DetailsM-CSA 919
ChainResidueDetails
AARG7electrostatic stabiliser
ASER61electrostatic stabiliser
AGLU110proton shuttle (general acid/base)
AGLU112electrostatic stabiliser

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PDB entries from 2024-09-18

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