1XSE
Crystal Structure of Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005496 | molecular_function | steroid binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0006706 | biological_process | steroid catabolic process |
A | 0008202 | biological_process | steroid metabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0030324 | biological_process | lung development |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
A | 0050661 | molecular_function | NADP binding |
A | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
A | 0102196 | molecular_function | cortisol dehydrogenase activity |
B | 0005496 | molecular_function | steroid binding |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0006706 | biological_process | steroid catabolic process |
B | 0008202 | biological_process | steroid metabolic process |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0030324 | biological_process | lung development |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
B | 0050661 | molecular_function | NADP binding |
B | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
B | 0102196 | molecular_function | cortisol dehydrogenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | BINDING SITE FOR RESIDUE NDP A 1300 |
Chain | Residue |
A | GLY41 |
A | GLY91 |
A | MET93 |
A | ASN119 |
A | HIS120 |
A | VAL121 |
A | TYR123 |
A | VAL142 |
A | VAL168 |
A | SER169 |
A | SER170 |
A | ALA42 |
A | TYR183 |
A | LYS187 |
A | LEU215 |
A | GLY216 |
A | LEU217 |
A | ILE218 |
A | THR220 |
A | THR222 |
A | ALA223 |
A | HOH1301 |
A | SER43 |
A | HOH1305 |
A | HOH1311 |
A | HOH1350 |
A | HOH1353 |
A | HOH1476 |
A | HOH1492 |
A | GLY45 |
A | ILE46 |
A | ALA65 |
A | ARG66 |
A | SER67 |
A | ARG77 |
site_id | AC2 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NDP B 2300 |
Chain | Residue |
B | GLY41 |
B | ALA42 |
B | SER43 |
B | GLY45 |
B | ILE46 |
B | ALA65 |
B | ARG66 |
B | SER67 |
B | GLY91 |
B | SER92 |
B | MET93 |
B | ASN119 |
B | HIS120 |
B | VAL121 |
B | TYR123 |
B | VAL168 |
B | SER169 |
B | SER170 |
B | TYR183 |
B | LYS187 |
B | LEU215 |
B | GLY216 |
B | LEU217 |
B | ILE218 |
B | THR220 |
B | THR222 |
B | ALA223 |
B | HOH2302 |
B | HOH2324 |
B | HOH2350 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvagkityplIapYSASKFALdGFFsTLR |
Chain | Residue | Details |
A | SER170-ARG198 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 |
Chain | Residue | Details |
A | TYR183 | |
B | TYR183 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15542590, ECO:0000269|PubMed:19473839, ECO:0000269|PubMed:19507261 |
Chain | Residue | Details |
A | GLY41 | |
B | ILE218 | |
A | SER92 | |
A | ASN119 | |
A | TYR183 | |
A | ILE218 | |
B | GLY41 | |
B | SER92 | |
B | ASN119 | |
B | TYR183 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER170 | |
B | SER170 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN207 | |
B | ASN207 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
A | LYS187 | |
A | SER170 | |
A | TYR183 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
B | LYS187 | |
B | SER170 | |
B | TYR183 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
A | LYS187 | |
A | SER170 | |
A | TYR183 | |
A | ASN143 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
B | LYS187 | |
B | SER170 | |
B | TYR183 | |
B | ASN143 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
A | LYS187 | |
A | ILE180 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
B | LYS187 | |
B | ILE180 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
A | LYS187 | |
A | TYR183 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
B | LYS187 | |
B | TYR183 |