1XQ7
Cyclophilin from Trypanosoma cruzi bound to cyclosporin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006457 | biological_process | protein folding |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| B | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006457 | biological_process | protein folding |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| C | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006457 | biological_process | protein folding |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR CHAIN D OF CYCLOSPORIN A |
| Chain | Residue |
| A | ARG57 |
| A | TRP122 |
| A | HIS127 |
| C | ALA104 |
| A | PHE62 |
| A | GLN65 |
| A | GLY74 |
| A | ALA102 |
| A | ASN103 |
| A | ALA104 |
| A | GLN112 |
| A | PHE114 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN E OF CYCLOSPORIN A |
| Chain | Residue |
| A | HOH2064 |
| A | HOH2066 |
| B | ARG57 |
| B | PHE62 |
| B | GLN65 |
| B | GLY74 |
| B | ALA102 |
| B | ASN103 |
| B | GLN112 |
| B | PHE114 |
| B | TRP122 |
| B | LEU123 |
| B | HIS127 |
| B | HOH2047 |
| B | HOH2049 |
| E | HOH2001 |
| E | HOH2002 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN F OF CYCLOSPORIN A |
| Chain | Residue |
| A | TRP122 |
| B | ALA104 |
| C | ARG57 |
| C | PHE62 |
| C | GLN65 |
| C | GLY74 |
| C | ALA102 |
| C | ASN103 |
| C | GLN112 |
| C | PHE114 |
| C | TRP122 |
| C | HIS127 |
| F | HOH2001 |
| F | HOH2002 |
| F | HOH2003 |
| F | HOH2004 |
| F | HOH2005 |
| F | HOH2006 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgSiFHRVIrnFMiQGG |
| Chain | Residue | Details |
| A | TYR50-GLY67 |
