Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1XPO

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006353	biological_process	DNA-templated transcription termination
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0042802	molecular_function	identical protein binding
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006353	biological_process	DNA-templated transcription termination
B	0008186	molecular_function	ATP-dependent activity, acting on RNA
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0042802	molecular_function	identical protein binding
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006353	biological_process	DNA-templated transcription termination
C	0008186	molecular_function	ATP-dependent activity, acting on RNA
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0042802	molecular_function	identical protein binding
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006353	biological_process	DNA-templated transcription termination
D	0008186	molecular_function	ATP-dependent activity, acting on RNA
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0042802	molecular_function	identical protein binding
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006353	biological_process	DNA-templated transcription termination
E	0008186	molecular_function	ATP-dependent activity, acting on RNA
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0042802	molecular_function	identical protein binding
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006353	biological_process	DNA-templated transcription termination
F	0008186	molecular_function	ATP-dependent activity, acting on RNA
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1601

Chain	Residue
A	THR185
A	ARG212
A	GLU215
A	AGS1600

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 2601

Chain	Residue
B	THR185
B	ARG212
B	AGS2600
B	BCM2701

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 3601

Chain	Residue
C	THR185
C	ASP265
C	AGS3600
C	BCM3701
C	LYS184

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 4601

Chain	Residue
D	LYS184
D	THR185
D	GLU211
D	AGS4600
D	BCM4701

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 5601

Chain	Residue
D	ARG366
E	THR185
E	ARG212
E	AGS5600
E	BCM5701

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 6601

Chain	Residue
F	THR185
F	GLU215
F	AGS6600
F	BCM6701

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AGS A 1600

Chain	Residue
A	THR158
A	PRO180
A	LYS181
A	ALA182
A	GLY183
A	LYS184
A	THR185
A	MET186
A	ARG212
A	PHE355
A	MG1601

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AGS B 2600

Chain	Residue
A	ARG366
A	LYS367
A	GLU369
B	PRO180
B	LYS181
B	ALA182
B	GLY183
B	LYS184
B	THR185
B	MET186
B	ARG212
B	PHE355
B	MG2601
B	BCM2701

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BCM B 2701

Chain	Residue
A	LYS336
A	GLY337
B	PRO180
B	LYS184
B	ASP210
B	GLU211
B	ASP265
B	SER266
B	ARG269
B	LEU320
B	THR323
B	AGS2600
B	MG2601

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AGS C 3600

Chain	Residue
B	ARG366
C	THR158
C	PRO180
C	LYS181
C	ALA182
C	GLY183
C	LYS184
C	THR185
C	MET186
C	ARG212
C	PHE355
C	MG3601
C	BCM3701

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BCM C 3701

Chain	Residue
B	LYS336
B	GLY337
C	PRO180
C	LYS184
C	ILE209
C	ASP210
C	GLU211
C	ARG212
C	ASP265
C	SER266
C	LEU320
C	THR323
C	AGS3600
C	MG3601

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AGS D 4600

Chain	Residue
D	THR185
D	MET186
D	ARG212
D	PHE355
D	MG4601
D	BCM4701
C	ARG366
D	THR158
D	PRO180
D	LYS181
D	ALA182
D	GLY183
D	LYS184

site_id	BC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BCM D 4701

Chain	Residue
C	LYS336
C	GLY337
C	ARG366
D	PRO180
D	LYS184
D	ASP210
D	GLU211
D	ARG212
D	ASP265
D	SER266
D	LEU320
D	THR323
D	AGS4600
D	MG4601

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AGS E 5600

Chain	Residue
D	ARG366
D	GLU369
E	THR158
E	PRO180
E	LYS181
E	ALA182
E	GLY183
E	LYS184
E	THR185
E	MET186
E	ARG212
E	PHE355
E	MG5601
E	BCM5701

site_id	BC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BCM E 5701

Chain	Residue
D	LYS336
D	GLY337
D	ARG366
E	PRO180
E	LYS184
E	ASP210
E	GLU211
E	ASP265
E	SER266
E	ARG269
E	LEU320
E	THR323
E	AGS5600
E	MG5601

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AGS F 6600

Chain	Residue
E	ARG366
F	GLU155
F	THR158
F	PRO180
F	LYS181
F	ALA182
F	GLY183
F	LYS184
F	THR185
F	MET186
F	ARG212
F	GLU215
F	PHE355
F	MG6601
F	BCM6701

site_id	BC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE BCM F 6701

Chain	Residue
E	LYS336
E	GLY337
E	ARG366
F	PRO180
F	LYS184
F	ILE209
F	ASP210
F	GLU211
F	ARG212
F	ASP265
F	SER266
F	ARG269
F	LEU320
F	THR323
F	AGS6600
F	MG6601

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	ASN151
B	ASN151
C	ASN151
D	ASN151
E	ASN151
F	ASN151

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING:

Chain	Residue	Details
A	LEU114
B	ILE209
B	ALA243
B	VAL246
C	LEU114
C	ARG144
C	MET147
C	ILE209
C	ALA243
C	VAL246
D	LEU114
A	ARG144
D	ARG144
D	MET147
D	ILE209
D	ALA243
D	VAL246
E	LEU114
E	ARG144
E	MET147
E	ILE209
E	ALA243
A	MET147
E	VAL246
F	LEU114
F	ARG144
F	MET147
F	ILE209
F	ALA243
F	VAL246
A	LYS181
A	ARG212
B	LYS181
A	ILE209
B	ARG212
C	LYS181
C	ARG212
D	LYS181
D	ARG212
E	LYS181
E	ARG212
F	LYS181
F	ARG212
A	ALA243
A	VAL246
B	LEU114
B	ARG144
B	MET147

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY169
B	GLY169
C	GLY169
D	GLY169
E	GLY169
F	GLY169

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: RNA-binding 2

Chain	Residue	Details
A	LYS326
B	LYS326
C	LYS326
D	LYS326
E	LYS326
F	LYS326

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
A	ARG366

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
D	ARG212
D	GLU211
D	LYS184

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
E	ARG212
E	GLU211
E	LYS184

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
F	ARG212
F	GLU211
F	LYS184

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
B	ARG366

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
C	ARG366

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
D	ARG366

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
E	ARG366

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
F	ARG366

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
A	ARG212
A	GLU211
A	LYS184

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
B	ARG212
B	GLU211
B	LYS184

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
C	ARG212
C	GLU211
C	LYS184

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)