Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | HOH1007 |
| A | HOH1008 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | HOH1004 |
| A | HOH1005 |
| A | HOH1006 |
| A | HOH1007 |
| A | ASP201 |
| A | CIO603 |
| A | HOH1003 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 2001 |
| Chain | Residue |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | HOH2007 |
| B | HOH2008 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 2002 |
| Chain | Residue |
| B | ASP201 |
| B | HOH2003 |
| B | HOH2004 |
| B | HOH2005 |
| B | HOH2006 |
| B | HOH2007 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CIO B 601 |
| Chain | Residue |
| B | HIS160 |
| B | THR271 |
| B | MET273 |
| B | LEU319 |
| B | ASN321 |
| B | ILE336 |
| B | MET337 |
| B | PHE340 |
| B | MET357 |
| B | GLN369 |
| B | PHE372 |
| B | HOH2005 |
| B | HOH2006 |
| B | HOH2061 |
| B | HOH2072 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE CIO A 603 |
| Chain | Residue |
| A | HIS160 |
| A | THR271 |
| A | MET273 |
| A | ASP318 |
| A | LEU319 |
| A | ASN321 |
| A | ILE336 |
| A | MET337 |
| A | PHE340 |
| A | MET357 |
| A | GLN369 |
| A | PHE372 |
| A | MG1002 |
| A | HOH1005 |
| A | HOH1006 |
| A | HOH1007 |
| A | HOH1044 |
| A | HOH1058 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 701 |
| Chain | Residue |
| A | PRO411 |
| B | ARG330 |
| B | GLU366 |
| B | TYR406 |
| B | EDO713 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 702 |
| Chain | Residue |
| A | LYS262 |
| A | ILE265 |
| A | ASP266 |
| A | HOH1021 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 703 |
| Chain | Residue |
| A | THR186 |
| A | GLU189 |
| A | ARG306 |
| A | HOH1026 |
| A | HOH1066 |
| B | ASP151 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 704 |
| Chain | Residue |
| A | GLN210 |
| A | HOH1012 |
| A | HOH1033 |
| A | HOH1042 |
| A | HOH1051 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 705 |
| Chain | Residue |
| A | LEU326 |
| A | ARG330 |
| B | EDO706 |
| B | HOH2014 |
| B | HOH2063 |
| B | HOH2236 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 706 |
| Chain | Residue |
| A | HOH1069 |
| B | EDO705 |
| B | HOH2096 |
| B | HOH2269 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 707 |
| Chain | Residue |
| A | GLU150 |
| A | ASP151 |
| A | TYR153 |
| A | ALA155 |
| A | ASN162 |
| A | HOH1067 |
| A | HOH1130 |
| B | GLN407 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 709 |
| Chain | Residue |
| B | HOH2219 |
| B | LYS255 |
| B | GLN258 |
| B | SER259 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 710 |
| Chain | Residue |
| B | LEU92 |
| B | SER113 |
| B | VAL120 |
| B | HOH2216 |
| B | HOH2283 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 711 |
| Chain | Residue |
| B | SER208 |
| B | PHE340 |
| B | GLN343 |
| B | SER355 |
| B | HOH2188 |
| B | HOH2248 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 712 |
| Chain | Residue |
| A | SER295 |
| A | GLY296 |
| A | HIS389 |
| A | PRO390 |
| A | ASP391 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 713 |
| Chain | Residue |
| B | ARG330 |
| B | THR333 |
| B | ASP334 |
| B | VAL365 |
| B | TYR406 |
| B | EDO701 |
| B | HOH2142 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 714 |
| Chain | Residue |
| A | TRP405 |
| A | HOH1257 |
| B | ASP401 |
| B | ASN402 |
| B | HOH2014 |
| B | HOH2260 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 715 |
| Chain | Residue |
| A | ASN115 |
| A | ALA155 |
| A | ASN162 |
| A | ILE163 |
| A | HOH1130 |
| A | HOH1223 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 716 |
| Chain | Residue |
| A | LEU175 |
| A | THR178 |
| A | TRP384 |
| A | VAL388 |
| A | ASP391 |
| A | ALA392 |
| A | ILE395 |
| A | HOH1100 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 717 |
| Chain | Residue |
| B | PHE238 |
| B | LEU241 |
| B | PHE249 |
| B | ARG257 |
| B | LEU260 |
| B | ARG261 |
| B | EDO718 |
| B | HOH2210 |
| B | HOH2233 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 718 |
| Chain | Residue |
| B | ARG257 |
| B | GLN258 |
| B | EDO717 |
| B | HOH2122 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 719 |
| Chain | Residue |
| A | ALA183 |
| A | VAL184 |
| A | HOH1073 |
| B | ASN115 |
| B | ARG116 |
| B | HOH2178 |
| B | HOH2273 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 720 |
| Chain | Residue |
| A | PHE238 |
| A | ARG257 |
| A | ARG261 |
| A | HOH1152 |
| A | HOH1194 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 721 |
| Chain | Residue |
| B | HOH2022 |
| B | HOH2183 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| Chain | Residue | Details |
| A | HIS160 | |
| A | ASN321 | |
| A | GLN369 | |
| B | HIS160 | |
| B | ASN321 | |
| B | GLN369 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS200 | |
| A | ASP318 | |
| B | HIS200 | |
| B | ASP318 | |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
