Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1XMM

Structure of human Dcps bound to m7GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
A	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
A	0000340	molecular_function	RNA 7-methylguanosine cap binding
A	0000932	cellular_component	P-body
A	0004532	molecular_function	RNA exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0110156	biological_process	mRNA methylguanosine-cap decapping
A	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
B	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
B	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
B	0000340	molecular_function	RNA 7-methylguanosine cap binding
B	0000932	cellular_component	P-body
B	0004532	molecular_function	RNA exonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0045292	biological_process	mRNA cis splicing, via spliceosome
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0110156	biological_process	mRNA methylguanosine-cap decapping
B	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
C	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
C	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
C	0000340	molecular_function	RNA 7-methylguanosine cap binding
C	0000932	cellular_component	P-body
C	0004532	molecular_function	RNA exonuclease activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0045292	biological_process	mRNA cis splicing, via spliceosome
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0110156	biological_process	mRNA methylguanosine-cap decapping
C	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
D	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
D	0000340	molecular_function	RNA 7-methylguanosine cap binding
D	0000932	cellular_component	P-body
D	0004532	molecular_function	RNA exonuclease activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0045292	biological_process	mRNA cis splicing, via spliceosome
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0110156	biological_process	mRNA methylguanosine-cap decapping
D	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 1601

Chain	Residue
A	LYS142
A	TYR143
A	TYR273
A	M7G401
A	HOH1690

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 602

Chain	Residue
B	HIS279
B	ARG294
B	HIS268
B	PRO271
B	SER272
B	HIS277

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 603

Chain	Residue
C	HIS268
C	PRO271
C	SER272
C	HIS277
C	HIS279
C	ARG294

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 D 1604

Chain	Residue
D	LYS142
D	TYR143
D	TYR273
D	M7G404

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE M7G A 401

Chain	Residue
A	LYS142
A	TRP175
A	GLU185
A	PRO204
A	ASP205
A	LEU206
A	LYS207
A	TYR217
A	ILE219
A	HIS268
A	PRO271
A	SER272
A	TYR273
A	HIS277
A	HIS279
A	ARG294
A	PO41601
A	HOH1705
B	ASN110
B	TYR113

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE M7G D 404

Chain	Residue
C	ASN110
C	TYR113
D	LYS142
D	TRP175
D	GLU185
D	PRO204
D	ASP205
D	LEU206
D	LYS207
D	TYR217
D	HIS268
D	PRO271
D	SER272
D	TYR273
D	HIS277
D	HIS279
D	ARG294
D	PO41604
D	HOH1610

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE G7M B 1502

Chain	Residue
B	TRP175
B	GLU185
B	ARG188
B	ASP205
B	LEU206
B	SER272
B	TYR273
B	HOH1528
B	HOH1590

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE G7M C 503

Chain	Residue
C	TRP175
C	GLU185
C	ILE203
C	ASP205
C	LEU206
C	LYS207
C	ILE219
C	SER272
C	HOH686

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. RvylhYlPsYyHLHVHFTA

Chain	Residue	Details
B	ARG264-ALA282

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Motif: {"description":"nuclear export sequence (NES)"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"Histidine triad motif"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15068804","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15769464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	44
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DAR7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)