1XMC
C323M mutant structure of mouse carnitine octanoyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005777 | cellular_component | peroxisome |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0008458 | molecular_function | carnitine O-octanoyltransferase activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009437 | biological_process | carnitine metabolic process |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0051791 | biological_process | medium-chain fatty acid metabolic process |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005777 | cellular_component | peroxisome |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0008458 | molecular_function | carnitine O-octanoyltransferase activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009437 | biological_process | carnitine metabolic process |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0051791 | biological_process | medium-chain fatty acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EPE A 613 |
| Chain | Residue |
| A | TRP85 |
| A | HOH678 |
| A | TYR90 |
| A | HIS327 |
| A | TYR439 |
| A | THR441 |
| A | THR452 |
| A | HOH616 |
| A | HOH628 |
| A | HOH650 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE EPE B 701 |
| Chain | Residue |
| B | TRP85 |
| B | TYR90 |
| B | HIS327 |
| B | ASP331 |
| B | TYR439 |
| B | THR441 |
| B | THR452 |
| B | MET558 |
| B | MPD702 |
| B | MPD707 |
| B | HOH721 |
| B | HOH873 |
| B | HOH928 |
| B | HOH1016 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD A 614 |
| Chain | Residue |
| A | PHE103 |
| A | HIS327 |
| A | ASP331 |
| A | ALA332 |
| A | SER544 |
| A | PHE566 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD B 702 |
| Chain | Residue |
| B | PHE103 |
| B | HIS327 |
| B | ALA332 |
| B | THR441 |
| B | PHE566 |
| B | EPE701 |
| B | HOH873 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B 703 |
| Chain | Residue |
| B | HIS191 |
| B | ASP204 |
| B | LYS268 |
| B | GLU366 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD B 705 |
| Chain | Residue |
| B | LYS33 |
| B | GLU52 |
| B | GLN59 |
| B | GLU366 |
| B | HOH840 |
| B | HOH858 |
| B | HOH1038 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD B 706 |
| Chain | Residue |
| B | LEU71 |
| B | ARG75 |
| B | SER257 |
| B | LEU258 |
| B | HOH750 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD B 707 |
| Chain | Residue |
| B | TYR439 |
| B | GLY537 |
| B | EPE701 |
| B | HOH890 |
| B | HOH928 |
Functional Information from PROSITE/UniProt
| site_id | PS00439 |
| Number of Residues | 16 |
| Details | ACYLTRANSF_C_1 Acyltransferases ChoActase / COT / CPT family signature 1. LPsLPVPaLeESLkkY |
| Chain | Residue | Details |
| A | LEU20-TYR35 |
| site_id | PS00440 |
| Number of Residues | 28 |
| Details | ACYLTRANSF_C_2 Acyltransferases ChoActase / COT / CPT family signature 2. RWgDKsYnLIsfaNGifgmccDHapyDA |
| Chain | Residue | Details |
| A | ARG305-ALA332 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Microbody targeting signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15492013","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| A | TYR90 | |
| A | PRO106 | |
| A | SER544 | |
| A | HIS327 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| B | TYR90 | |
| B | PRO106 | |
| B | SER544 | |
| B | HIS327 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| A | SER544 | |
| A | HIS327 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| B | SER544 | |
| B | HIS327 |
