1XJQ

ADP Complex OF HUMAN PAPS SYNTHETASE 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000103	biological_process	sulfate assimilation
A	0001501	biological_process	skeletal system development
A	0004020	molecular_function	adenylylsulfate kinase activity
A	0004781	molecular_function	sulfate adenylyltransferase (ATP) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042803	molecular_function	protein homodimerization activity
A	0050428	biological_process	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
B	0000103	biological_process	sulfate assimilation
B	0001501	biological_process	skeletal system development
B	0004020	molecular_function	adenylylsulfate kinase activity
B	0004781	molecular_function	sulfate adenylyltransferase (ATP) activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042803	molecular_function	protein homodimerization activity
B	0050428	biological_process	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP A 900

Chain	Residue
A	PHE418
A	GLY521
A	ARG522
A	PRO524
A	ALA525
A	ARG561
A	VAL562
A	ALA563
A	HOH907
A	HOH1131
A	HOH1173
A	GLN419
A	HOH1187
A	HOH1189
A	LEU420
A	ARG421
A	ASN422
A	HIS428
A	LEU431
A	MET495
A	VAL520

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP B 800

Chain	Residue
B	LEU60
B	GLY62
B	ALA63
B	GLY64
B	LYS65
B	THR66
B	THR67
B	ARG168
B	VAL170
B	THR204
B	CYS207
B	ASP208
B	VAL209
B	CYS212
B	HOH1047
B	HOH1081
B	HOH1087

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP B 900

Chain	Residue
B	PHE418
B	GLN419
B	LEU420
B	ARG421
B	ASN422
B	HIS428
B	LEU431
B	MET495
B	VAL520
B	GLY521
B	ARG522
B	PRO524
B	ALA525
B	ARG561
B	VAL562
B	ALA563
B	HOH915
B	HOH1060
B	HOH1096
B	HOH1120
B	HOH1187

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15755455","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17540769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1X6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17540769","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15755455","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17540769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1X6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15755455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	390
Details	Region: {"description":"Sulfate adenylyltransferase","evidences":[{"source":"PubMed","id":"15755455","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
B	HIS428
B	ARG421
B	HIS425

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
A	HIS428
A	ARG421
A	HIS425

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
B	ARG522

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
A	ARG522

---