1XJG
Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dATP-UDP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| A | 0031419 | molecular_function | cobalamin binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0031419 | molecular_function | cobalamin binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG B 1005 |
| Chain | Residue |
| B | DTP1003 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG A 1006 |
| Chain | Residue |
| A | DTP1004 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UDP A 1001 |
| Chain | Residue |
| A | GLU324 |
| A | ALA489 |
| A | PRO490 |
| A | THR491 |
| A | GLY492 |
| A | SER493 |
| A | ILE494 |
| A | ASN90 |
| A | SER91 |
| A | ALA133 |
| A | GLY162 |
| A | ASN320 |
| A | PRO321 |
| A | CYS322 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UDP B 1002 |
| Chain | Residue |
| B | ASN90 |
| B | SER91 |
| B | ALA133 |
| B | GLY162 |
| B | GLN203 |
| B | ASN320 |
| B | CYS322 |
| B | GLU324 |
| B | ALA489 |
| B | PRO490 |
| B | THR491 |
| B | GLY492 |
| B | SER493 |
| B | ILE494 |
| B | HOH1088 |
| B | HOH1101 |
| B | HOH1103 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE DTP B 1003 |
| Chain | Residue |
| A | HIS127 |
| A | LYS158 |
| A | VAL200 |
| A | VAL201 |
| A | LYS202 |
| B | ASP141 |
| B | SER142 |
| B | ILE143 |
| B | ARG171 |
| B | VAL177 |
| B | ALA178 |
| B | GLY179 |
| B | LYS183 |
| B | ALA184 |
| B | SER185 |
| B | MG1005 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DTP A 1004 |
| Chain | Residue |
| A | ASP141 |
| A | SER142 |
| A | ILE143 |
| A | ARG171 |
| A | VAL177 |
| A | ALA178 |
| A | GLY179 |
| A | THR180 |
| A | LYS183 |
| A | ALA184 |
| A | SER185 |
| A | MG1006 |
| B | LYS158 |
| B | VAL201 |
| B | LYS202 |
