1XFU

Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004016	molecular_function	adenylate cyclase activity
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0006171	biological_process	cAMP biosynthetic process
A	0008237	molecular_function	metallopeptidase activity
A	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
A	0010856	molecular_function	adenylate cyclase activator activity
A	0016829	molecular_function	lyase activity
A	0030430	cellular_component	host cell cytoplasm
A	0036094	molecular_function	small molecule binding
A	0044164	cellular_component	host cell cytosol
A	0046872	molecular_function	metal ion binding
A	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
A	0090729	molecular_function	toxin activity
A	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
A	1902494	cellular_component	catalytic complex
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004016	molecular_function	adenylate cyclase activity
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0006171	biological_process	cAMP biosynthetic process
B	0008237	molecular_function	metallopeptidase activity
B	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
B	0010856	molecular_function	adenylate cyclase activator activity
B	0016829	molecular_function	lyase activity
B	0030430	cellular_component	host cell cytoplasm
B	0036094	molecular_function	small molecule binding
B	0044164	cellular_component	host cell cytosol
B	0046872	molecular_function	metal ion binding
B	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
B	0090729	molecular_function	toxin activity
B	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
B	1902494	cellular_component	catalytic complex
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004016	molecular_function	adenylate cyclase activity
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0006171	biological_process	cAMP biosynthetic process
C	0008237	molecular_function	metallopeptidase activity
C	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
C	0010856	molecular_function	adenylate cyclase activator activity
C	0016829	molecular_function	lyase activity
C	0030430	cellular_component	host cell cytoplasm
C	0036094	molecular_function	small molecule binding
C	0044164	cellular_component	host cell cytosol
C	0046872	molecular_function	metal ion binding
C	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
C	0090729	molecular_function	toxin activity
C	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
C	1902494	cellular_component	catalytic complex
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004016	molecular_function	adenylate cyclase activity
D	0005516	molecular_function	calmodulin binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0006171	biological_process	cAMP biosynthetic process
D	0008237	molecular_function	metallopeptidase activity
D	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
D	0010856	molecular_function	adenylate cyclase activator activity
D	0016829	molecular_function	lyase activity
D	0030430	cellular_component	host cell cytoplasm
D	0036094	molecular_function	small molecule binding
D	0044164	cellular_component	host cell cytosol
D	0046872	molecular_function	metal ion binding
D	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
D	0090729	molecular_function	toxin activity
D	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
D	1902494	cellular_component	catalytic complex
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004016	molecular_function	adenylate cyclase activity
E	0005516	molecular_function	calmodulin binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0006171	biological_process	cAMP biosynthetic process
E	0008237	molecular_function	metallopeptidase activity
E	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
E	0010856	molecular_function	adenylate cyclase activator activity
E	0016829	molecular_function	lyase activity
E	0030430	cellular_component	host cell cytoplasm
E	0036094	molecular_function	small molecule binding
E	0044164	cellular_component	host cell cytosol
E	0046872	molecular_function	metal ion binding
E	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
E	0090729	molecular_function	toxin activity
E	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
E	1902494	cellular_component	catalytic complex
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004016	molecular_function	adenylate cyclase activity
F	0005516	molecular_function	calmodulin binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0006171	biological_process	cAMP biosynthetic process
F	0008237	molecular_function	metallopeptidase activity
F	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
F	0010856	molecular_function	adenylate cyclase activator activity
F	0016829	molecular_function	lyase activity
F	0030430	cellular_component	host cell cytoplasm
F	0036094	molecular_function	small molecule binding
F	0044164	cellular_component	host cell cytosol
F	0046872	molecular_function	metal ion binding
F	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
F	0090729	molecular_function	toxin activity
F	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
F	1902494	cellular_component	catalytic complex
O	0000086	biological_process	G2/M transition of mitotic cell cycle
O	0000922	cellular_component	spindle pole
O	0002027	biological_process	regulation of heart rate
O	0005246	molecular_function	calcium channel regulator activity
O	0005509	molecular_function	calcium ion binding
O	0005513	biological_process	detection of calcium ion
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005876	cellular_component	spindle microtubule
O	0005886	cellular_component	plasma membrane
O	0005929	cellular_component	cilium
O	0007186	biological_process	G protein-coupled receptor signaling pathway
O	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
O	0008076	cellular_component	voltage-gated potassium channel complex
O	0010856	molecular_function	adenylate cyclase activator activity
O	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
O	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
O	0016020	cellular_component	membrane
O	0016240	biological_process	autophagosome membrane docking
O	0019855	molecular_function	calcium channel inhibitor activity
O	0019901	molecular_function	protein kinase binding
O	0021762	biological_process	substantia nigra development
O	0030017	cellular_component	sarcomere
O	0030672	cellular_component	synaptic vesicle membrane
O	0031432	molecular_function	titin binding
O	0031514	cellular_component	motile cilium
O	0031982	cellular_component	vesicle
O	0032465	biological_process	regulation of cytokinesis
O	0032991	cellular_component	protein-containing complex
O	0034704	cellular_component	calcium channel complex
O	0035458	biological_process	cellular response to interferon-beta
O	0042995	cellular_component	cell projection
O	0043209	cellular_component	myelin sheath
O	0043539	molecular_function	protein serine/threonine kinase activator activity
O	0044305	cellular_component	calyx of Held
O	0044325	molecular_function	transmembrane transporter binding
O	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
O	0046872	molecular_function	metal ion binding
O	0048306	molecular_function	calcium-dependent protein binding
O	0050848	biological_process	regulation of calcium-mediated signaling
O	0051592	biological_process	response to calcium ion
O	0055117	biological_process	regulation of cardiac muscle contraction
O	0060291	biological_process	long-term synaptic potentiation
O	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
O	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
O	0071346	biological_process	cellular response to type II interferon
O	0072542	molecular_function	protein phosphatase activator activity
O	0097225	cellular_component	sperm midpiece
O	0097720	biological_process	calcineurin-mediated signaling
O	0098901	biological_process	regulation of cardiac muscle cell action potential
O	0099523	cellular_component	presynaptic cytosol
O	0140056	biological_process	organelle localization by membrane tethering
O	0140238	biological_process	presynaptic endocytosis
O	0141110	molecular_function	transporter inhibitor activity
O	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
O	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
O	1902494	cellular_component	catalytic complex
O	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
O	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
P	0000086	biological_process	G2/M transition of mitotic cell cycle
P	0000922	cellular_component	spindle pole
P	0002027	biological_process	regulation of heart rate
P	0005246	molecular_function	calcium channel regulator activity
P	0005509	molecular_function	calcium ion binding
P	0005513	biological_process	detection of calcium ion
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005813	cellular_component	centrosome
P	0005819	cellular_component	spindle
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005876	cellular_component	spindle microtubule
P	0005886	cellular_component	plasma membrane
P	0005929	cellular_component	cilium
P	0007186	biological_process	G protein-coupled receptor signaling pathway
P	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
P	0008076	cellular_component	voltage-gated potassium channel complex
P	0010856	molecular_function	adenylate cyclase activator activity
P	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
P	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
P	0016020	cellular_component	membrane
P	0016240	biological_process	autophagosome membrane docking
P	0019855	molecular_function	calcium channel inhibitor activity
P	0019901	molecular_function	protein kinase binding
P	0021762	biological_process	substantia nigra development
P	0030017	cellular_component	sarcomere
P	0030672	cellular_component	synaptic vesicle membrane
P	0031432	molecular_function	titin binding
P	0031514	cellular_component	motile cilium
P	0031982	cellular_component	vesicle
P	0032465	biological_process	regulation of cytokinesis
P	0032991	cellular_component	protein-containing complex
P	0034704	cellular_component	calcium channel complex
P	0035458	biological_process	cellular response to interferon-beta
P	0042995	cellular_component	cell projection
P	0043209	cellular_component	myelin sheath
P	0043539	molecular_function	protein serine/threonine kinase activator activity
P	0044305	cellular_component	calyx of Held
P	0044325	molecular_function	transmembrane transporter binding
P	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
P	0046872	molecular_function	metal ion binding
P	0048306	molecular_function	calcium-dependent protein binding
P	0050848	biological_process	regulation of calcium-mediated signaling
P	0051592	biological_process	response to calcium ion
P	0055117	biological_process	regulation of cardiac muscle contraction
P	0060291	biological_process	long-term synaptic potentiation
P	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
P	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
P	0071346	biological_process	cellular response to type II interferon
P	0072542	molecular_function	protein phosphatase activator activity
P	0097225	cellular_component	sperm midpiece
P	0097720	biological_process	calcineurin-mediated signaling
P	0098901	biological_process	regulation of cardiac muscle cell action potential
P	0099523	cellular_component	presynaptic cytosol
P	0140056	biological_process	organelle localization by membrane tethering
P	0140238	biological_process	presynaptic endocytosis
P	0141110	molecular_function	transporter inhibitor activity
P	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
P	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
P	1902494	cellular_component	catalytic complex
P	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
P	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
Q	0000086	biological_process	G2/M transition of mitotic cell cycle
Q	0000922	cellular_component	spindle pole
Q	0002027	biological_process	regulation of heart rate
Q	0005246	molecular_function	calcium channel regulator activity
Q	0005509	molecular_function	calcium ion binding
Q	0005513	biological_process	detection of calcium ion
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005819	cellular_component	spindle
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0005876	cellular_component	spindle microtubule
Q	0005886	cellular_component	plasma membrane
Q	0005929	cellular_component	cilium
Q	0007186	biological_process	G protein-coupled receptor signaling pathway
Q	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
Q	0008076	cellular_component	voltage-gated potassium channel complex
Q	0010856	molecular_function	adenylate cyclase activator activity
Q	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Q	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Q	0016020	cellular_component	membrane
Q	0016240	biological_process	autophagosome membrane docking
Q	0019855	molecular_function	calcium channel inhibitor activity
Q	0019901	molecular_function	protein kinase binding
Q	0021762	biological_process	substantia nigra development
Q	0030017	cellular_component	sarcomere
Q	0030672	cellular_component	synaptic vesicle membrane
Q	0031432	molecular_function	titin binding
Q	0031514	cellular_component	motile cilium
Q	0031982	cellular_component	vesicle
Q	0032465	biological_process	regulation of cytokinesis
Q	0032991	cellular_component	protein-containing complex
Q	0034704	cellular_component	calcium channel complex
Q	0035458	biological_process	cellular response to interferon-beta
Q	0042995	cellular_component	cell projection
Q	0043209	cellular_component	myelin sheath
Q	0043539	molecular_function	protein serine/threonine kinase activator activity
Q	0044305	cellular_component	calyx of Held
Q	0044325	molecular_function	transmembrane transporter binding
Q	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
Q	0046872	molecular_function	metal ion binding
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0050848	biological_process	regulation of calcium-mediated signaling
Q	0051592	biological_process	response to calcium ion
Q	0055117	biological_process	regulation of cardiac muscle contraction
Q	0060291	biological_process	long-term synaptic potentiation
Q	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
Q	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
Q	0071346	biological_process	cellular response to type II interferon
Q	0072542	molecular_function	protein phosphatase activator activity
Q	0097225	cellular_component	sperm midpiece
Q	0097720	biological_process	calcineurin-mediated signaling
Q	0098901	biological_process	regulation of cardiac muscle cell action potential
Q	0099523	cellular_component	presynaptic cytosol
Q	0140056	biological_process	organelle localization by membrane tethering
Q	0140238	biological_process	presynaptic endocytosis
Q	0141110	molecular_function	transporter inhibitor activity
Q	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
Q	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
Q	1902494	cellular_component	catalytic complex
Q	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
Q	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
R	0000086	biological_process	G2/M transition of mitotic cell cycle
R	0000922	cellular_component	spindle pole
R	0002027	biological_process	regulation of heart rate
R	0005246	molecular_function	calcium channel regulator activity
R	0005509	molecular_function	calcium ion binding
R	0005513	biological_process	detection of calcium ion
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005819	cellular_component	spindle
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0005876	cellular_component	spindle microtubule
R	0005886	cellular_component	plasma membrane
R	0005929	cellular_component	cilium
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
R	0008076	cellular_component	voltage-gated potassium channel complex
R	0010856	molecular_function	adenylate cyclase activator activity
R	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
R	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
R	0016020	cellular_component	membrane
R	0016240	biological_process	autophagosome membrane docking
R	0019855	molecular_function	calcium channel inhibitor activity
R	0019901	molecular_function	protein kinase binding
R	0021762	biological_process	substantia nigra development
R	0030017	cellular_component	sarcomere
R	0030672	cellular_component	synaptic vesicle membrane
R	0031432	molecular_function	titin binding
R	0031514	cellular_component	motile cilium
R	0031982	cellular_component	vesicle
R	0032465	biological_process	regulation of cytokinesis
R	0032991	cellular_component	protein-containing complex
R	0034704	cellular_component	calcium channel complex
R	0035458	biological_process	cellular response to interferon-beta
R	0042995	cellular_component	cell projection
R	0043209	cellular_component	myelin sheath
R	0043539	molecular_function	protein serine/threonine kinase activator activity
R	0044305	cellular_component	calyx of Held
R	0044325	molecular_function	transmembrane transporter binding
R	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
R	0046872	molecular_function	metal ion binding
R	0048306	molecular_function	calcium-dependent protein binding
R	0050848	biological_process	regulation of calcium-mediated signaling
R	0051592	biological_process	response to calcium ion
R	0055117	biological_process	regulation of cardiac muscle contraction
R	0060291	biological_process	long-term synaptic potentiation
R	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
R	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
R	0071346	biological_process	cellular response to type II interferon
R	0072542	molecular_function	protein phosphatase activator activity
R	0097225	cellular_component	sperm midpiece
R	0097720	biological_process	calcineurin-mediated signaling
R	0098901	biological_process	regulation of cardiac muscle cell action potential
R	0099523	cellular_component	presynaptic cytosol
R	0140056	biological_process	organelle localization by membrane tethering
R	0140238	biological_process	presynaptic endocytosis
R	0141110	molecular_function	transporter inhibitor activity
R	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
R	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
R	1902494	cellular_component	catalytic complex
R	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
R	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
S	0000086	biological_process	G2/M transition of mitotic cell cycle
S	0000922	cellular_component	spindle pole
S	0002027	biological_process	regulation of heart rate
S	0005246	molecular_function	calcium channel regulator activity
S	0005509	molecular_function	calcium ion binding
S	0005513	biological_process	detection of calcium ion
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005819	cellular_component	spindle
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005876	cellular_component	spindle microtubule
S	0005886	cellular_component	plasma membrane
S	0005929	cellular_component	cilium
S	0007186	biological_process	G protein-coupled receptor signaling pathway
S	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
S	0008076	cellular_component	voltage-gated potassium channel complex
S	0010856	molecular_function	adenylate cyclase activator activity
S	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
S	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
S	0016020	cellular_component	membrane
S	0016240	biological_process	autophagosome membrane docking
S	0019855	molecular_function	calcium channel inhibitor activity
S	0019901	molecular_function	protein kinase binding
S	0021762	biological_process	substantia nigra development
S	0030017	cellular_component	sarcomere
S	0030672	cellular_component	synaptic vesicle membrane
S	0031432	molecular_function	titin binding
S	0031514	cellular_component	motile cilium
S	0031982	cellular_component	vesicle
S	0032465	biological_process	regulation of cytokinesis
S	0032991	cellular_component	protein-containing complex
S	0034704	cellular_component	calcium channel complex
S	0035458	biological_process	cellular response to interferon-beta
S	0042995	cellular_component	cell projection
S	0043209	cellular_component	myelin sheath
S	0043539	molecular_function	protein serine/threonine kinase activator activity
S	0044305	cellular_component	calyx of Held
S	0044325	molecular_function	transmembrane transporter binding
S	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
S	0046872	molecular_function	metal ion binding
S	0048306	molecular_function	calcium-dependent protein binding
S	0050848	biological_process	regulation of calcium-mediated signaling
S	0051592	biological_process	response to calcium ion
S	0055117	biological_process	regulation of cardiac muscle contraction
S	0060291	biological_process	long-term synaptic potentiation
S	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
S	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
S	0071346	biological_process	cellular response to type II interferon
S	0072542	molecular_function	protein phosphatase activator activity
S	0097225	cellular_component	sperm midpiece
S	0097720	biological_process	calcineurin-mediated signaling
S	0098901	biological_process	regulation of cardiac muscle cell action potential
S	0099523	cellular_component	presynaptic cytosol
S	0140056	biological_process	organelle localization by membrane tethering
S	0140238	biological_process	presynaptic endocytosis
S	0141110	molecular_function	transporter inhibitor activity
S	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
S	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
S	1902494	cellular_component	catalytic complex
S	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
S	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
T	0000086	biological_process	G2/M transition of mitotic cell cycle
T	0000922	cellular_component	spindle pole
T	0002027	biological_process	regulation of heart rate
T	0005246	molecular_function	calcium channel regulator activity
T	0005509	molecular_function	calcium ion binding
T	0005513	biological_process	detection of calcium ion
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005813	cellular_component	centrosome
T	0005819	cellular_component	spindle
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005876	cellular_component	spindle microtubule
T	0005886	cellular_component	plasma membrane
T	0005929	cellular_component	cilium
T	0007186	biological_process	G protein-coupled receptor signaling pathway
T	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
T	0008076	cellular_component	voltage-gated potassium channel complex
T	0010856	molecular_function	adenylate cyclase activator activity
T	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
T	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
T	0016020	cellular_component	membrane
T	0016240	biological_process	autophagosome membrane docking
T	0019855	molecular_function	calcium channel inhibitor activity
T	0019901	molecular_function	protein kinase binding
T	0021762	biological_process	substantia nigra development
T	0030017	cellular_component	sarcomere
T	0030672	cellular_component	synaptic vesicle membrane
T	0031432	molecular_function	titin binding
T	0031514	cellular_component	motile cilium
T	0031982	cellular_component	vesicle
T	0032465	biological_process	regulation of cytokinesis
T	0032991	cellular_component	protein-containing complex
T	0034704	cellular_component	calcium channel complex
T	0035458	biological_process	cellular response to interferon-beta
T	0042995	cellular_component	cell projection
T	0043209	cellular_component	myelin sheath
T	0043539	molecular_function	protein serine/threonine kinase activator activity
T	0044305	cellular_component	calyx of Held
T	0044325	molecular_function	transmembrane transporter binding
T	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
T	0046872	molecular_function	metal ion binding
T	0048306	molecular_function	calcium-dependent protein binding
T	0050848	biological_process	regulation of calcium-mediated signaling
T	0051592	biological_process	response to calcium ion
T	0055117	biological_process	regulation of cardiac muscle contraction
T	0060291	biological_process	long-term synaptic potentiation
T	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
T	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
T	0071346	biological_process	cellular response to type II interferon
T	0072542	molecular_function	protein phosphatase activator activity
T	0097225	cellular_component	sperm midpiece
T	0097720	biological_process	calcineurin-mediated signaling
T	0098901	biological_process	regulation of cardiac muscle cell action potential
T	0099523	cellular_component	presynaptic cytosol
T	0140056	biological_process	organelle localization by membrane tethering
T	0140238	biological_process	presynaptic endocytosis
T	0141110	molecular_function	transporter inhibitor activity
T	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
T	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
T	1902494	cellular_component	catalytic complex
T	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
T	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 900

Chain	Residue
A	ASP491
A	ASP493
A	HIS577

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 901

Chain	Residue
B	ASP491
B	ASP493
B	HIS577

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 902

Chain	Residue
C	ASP491
C	ASP493
C	HIS577

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 903

Chain	Residue
D	ASP491
D	ASP493
D	HIS577

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 904

Chain	Residue
E	ASP491
E	ASP493
E	HIS577

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG F 905

Chain	Residue
F	ASP491
F	ASP493
F	HIS577

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA O 701

Chain	Residue
O	ASP20
O	ASP22
O	ASP24
O	THR26

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA O 801

Chain	Residue
O	ASP129
O	ASP131
O	ASP133
O	GLN135
O	GLU140

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA O 802

Chain	Residue
O	ASP93
O	ASP95
O	ASN97
O	TYR99
O	GLU104

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA P 703

Chain	Residue
P	ASP20
P	ASP22
P	ASP24
P	THR26

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA P 803

Chain	Residue
P	ASP129
P	ASP131
P	ASP133
P	GLN135
P	GLU140

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA P 804

Chain	Residue
P	ASP93
P	ASP95
P	ASN97
P	TYR99
P	GLU104

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA Q 705

Chain	Residue
Q	ASP20
Q	ASP22
Q	ASP24
Q	THR26

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA Q 805

Chain	Residue
Q	ASP129
Q	ASP131
Q	ASP133
Q	GLN135
Q	GLU140

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA Q 806

Chain	Residue
Q	ASP93
Q	ASP95
Q	ASN97
Q	TYR99
Q	GLU104

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA R 707

Chain	Residue
R	ASP20
R	ASP22
R	ASP24
R	THR26

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA R 807

Chain	Residue
R	ASP129
R	ASP131
R	ASP133
R	GLN135
R	GLU140

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA R 808

Chain	Residue
R	ASP93
R	ASP95
R	ASN97
R	TYR99
R	GLU104

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA S 709

Chain	Residue
S	ASP20
S	ASP22
S	ASP24
S	THR26

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA S 809

Chain	Residue
S	ASP129
S	ASP131
S	ASP133
S	GLN135
S	GLU140

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA S 810

Chain	Residue
S	ASP93
S	ASP95
S	ASN97
S	TYR99
S	GLU104

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA T 711

Chain	Residue
T	ASP20
T	ASP22
T	ASP24
T	THR26

---

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA T 811

Chain	Residue
T	ASP129
T	ASP131
T	ASP133
T	GLN135
T	GLU140

---

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA T 812

Chain	Residue
T	ASN97
T	TYR99
T	GLU104
T	ASP93
T	ASP95

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
O	ASP20-LEU32
O	ASP56-PHE68
O	ASP93-LEU105
O	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	330
Details	Region: {"description":"Catalytic CA1","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	834
Details	Region: {"description":"Catalytic CB","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	792
Details	Region: {"description":"Catalytic CA2","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15719022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y0V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15719022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XFW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	210
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	210
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	210
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	192
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	432
Details	Region: {"description":"Necessary and sufficient for interaction with PCP4","evidences":[{"source":"PubMed","id":"27876793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29724949","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP29","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	6
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---