Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1XFB

Human Brain Fructose 1,6-(bis)phosphate Aldolase (C isozyme)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006000	biological_process	fructose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0008092	molecular_function	cytoskeletal protein binding
A	0016829	molecular_function	lyase activity
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0030855	biological_process	epithelial cell differentiation
A	0034774	cellular_component	secretory granule lumen
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006000	biological_process	fructose metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0008092	molecular_function	cytoskeletal protein binding
B	0016829	molecular_function	lyase activity
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0030855	biological_process	epithelial cell differentiation
B	0034774	cellular_component	secretory granule lumen
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004332	molecular_function	fructose-bisphosphate aldolase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006000	biological_process	fructose metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0008092	molecular_function	cytoskeletal protein binding
C	0016829	molecular_function	lyase activity
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0030855	biological_process	epithelial cell differentiation
C	0034774	cellular_component	secretory granule lumen
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0004332	molecular_function	fructose-bisphosphate aldolase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0006000	biological_process	fructose metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0008092	molecular_function	cytoskeletal protein binding
D	0016829	molecular_function	lyase activity
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0030855	biological_process	epithelial cell differentiation
D	0034774	cellular_component	secretory granule lumen
D	0070062	cellular_component	extracellular exosome
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004332	molecular_function	fructose-bisphosphate aldolase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006000	biological_process	fructose metabolic process
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0008092	molecular_function	cytoskeletal protein binding
E	0016829	molecular_function	lyase activity
E	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
E	0030855	biological_process	epithelial cell differentiation
E	0034774	cellular_component	secretory granule lumen
E	0070062	cellular_component	extracellular exosome
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0004332	molecular_function	fructose-bisphosphate aldolase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0006000	biological_process	fructose metabolic process
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0008092	molecular_function	cytoskeletal protein binding
F	0016829	molecular_function	lyase activity
F	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
F	0030855	biological_process	epithelial cell differentiation
F	0034774	cellular_component	secretory granule lumen
F	0070062	cellular_component	extracellular exosome
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0004332	molecular_function	fructose-bisphosphate aldolase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0006000	biological_process	fructose metabolic process
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0008092	molecular_function	cytoskeletal protein binding
G	0016829	molecular_function	lyase activity
G	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
G	0030855	biological_process	epithelial cell differentiation
G	0034774	cellular_component	secretory granule lumen
G	0070062	cellular_component	extracellular exosome
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0004332	molecular_function	fructose-bisphosphate aldolase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0006000	biological_process	fructose metabolic process
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0008092	molecular_function	cytoskeletal protein binding
H	0016829	molecular_function	lyase activity
H	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
H	0030855	biological_process	epithelial cell differentiation
H	0034774	cellular_component	secretory granule lumen
H	0070062	cellular_component	extracellular exosome
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0004332	molecular_function	fructose-bisphosphate aldolase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0006000	biological_process	fructose metabolic process
I	0006094	biological_process	gluconeogenesis
I	0006096	biological_process	glycolytic process
I	0008092	molecular_function	cytoskeletal protein binding
I	0016829	molecular_function	lyase activity
I	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
I	0030855	biological_process	epithelial cell differentiation
I	0034774	cellular_component	secretory granule lumen
I	0070062	cellular_component	extracellular exosome
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0004332	molecular_function	fructose-bisphosphate aldolase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0006000	biological_process	fructose metabolic process
J	0006094	biological_process	gluconeogenesis
J	0006096	biological_process	glycolytic process
J	0008092	molecular_function	cytoskeletal protein binding
J	0016829	molecular_function	lyase activity
J	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
J	0030855	biological_process	epithelial cell differentiation
J	0034774	cellular_component	secretory granule lumen
J	0070062	cellular_component	extracellular exosome
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0004332	molecular_function	fructose-bisphosphate aldolase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0006000	biological_process	fructose metabolic process
K	0006094	biological_process	gluconeogenesis
K	0006096	biological_process	glycolytic process
K	0008092	molecular_function	cytoskeletal protein binding
K	0016829	molecular_function	lyase activity
K	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
K	0030855	biological_process	epithelial cell differentiation
K	0034774	cellular_component	secretory granule lumen
K	0070062	cellular_component	extracellular exosome
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0004332	molecular_function	fructose-bisphosphate aldolase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0006000	biological_process	fructose metabolic process
L	0006094	biological_process	gluconeogenesis
L	0006096	biological_process	glycolytic process
L	0008092	molecular_function	cytoskeletal protein binding
L	0016829	molecular_function	lyase activity
L	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
L	0030855	biological_process	epithelial cell differentiation
L	0034774	cellular_component	secretory granule lumen
L	0070062	cellular_component	extracellular exosome
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VyLEGtLLKPN

Chain	Residue	Details
A	VAL222-ASN232

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Schiff-base intermediate with dihydroxyacetone-P"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05065","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P05065","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
A	ASP34
A	LYS230
A	GLU188

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
J	ASP34
J	LYS230
J	GLU188

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
K	ASP34
K	LYS230
K	GLU188

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
L	ASP34
L	LYS230
L	GLU188

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
B	ASP34
B	LYS230
B	GLU188

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
C	ASP34
C	LYS230
C	GLU188

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
D	ASP34
D	LYS230
D	GLU188

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
E	ASP34
E	LYS230
E	GLU188

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
F	ASP34
F	LYS230
F	GLU188

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
G	ASP34
G	LYS230
G	GLU188

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
H	ASP34
H	LYS230
H	GLU188

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
I	ASP34
I	LYS230
I	GLU188

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)