1XDT

COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005886	cellular_component	plasma membrane
T	0008320	molecular_function	protein transmembrane transporter activity
T	0016757	molecular_function	glycosyltransferase activity
T	0016779	molecular_function	nucleotidyltransferase activity
T	0035821	biological_process	modulation of process of another organism
T	0042802	molecular_function	identical protein binding
T	0047286	molecular_function	NAD+-diphthamide ADP-ribosyltransferase activity
T	0071806	biological_process	protein transmembrane transport
T	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CiChpGyhGErC

Chain	Residue	Details
R	CYS132-CYS143

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CiChpGYhger....C

Chain	Residue	Details
R	CYS132-CYS143

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Plays a critical role in diphtheria toxin binding and toxin sensitivity => ECO:0000250

Chain	Residue	Details
R	GLU141

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:1556128

Chain	Residue	Details
R	THR75
R	THR85

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Modification inactivates enzyme

Chain	Residue	Details
T	TRP153

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by furin => ECO:0000269|PubMed:8253774

Chain	Residue	Details
T	ARG193

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1tox

Chain	Residue	Details
T	GLU148

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site_id	MCSA1
Number of Residues	1
Details	M-CSA 773

Chain	Residue	Details
T	GLU148	electrostatic stabiliser

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