Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1XDM

Structure of human aldolase B associated with hereditary fructose intolerance (A149P), at 291K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005515	molecular_function	protein binding
A	0005815	cellular_component	microtubule organizing center
A	0005829	cellular_component	cytosol
A	0006000	biological_process	fructose metabolic process
A	0006001	biological_process	fructose catabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0008092	molecular_function	cytoskeletal protein binding
A	0016829	molecular_function	lyase activity
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0034451	cellular_component	centriolar satellite
A	0042802	molecular_function	identical protein binding
A	0051117	molecular_function	ATPase binding
A	0060090	molecular_function	molecular adaptor activity
A	0061609	molecular_function	fructose-1-phosphate aldolase activity
A	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
A	0070061	molecular_function	fructose binding
A	0070062	cellular_component	extracellular exosome
A	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
A	1905856	biological_process	negative regulation of pentose-phosphate shunt
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005515	molecular_function	protein binding
B	0005815	cellular_component	microtubule organizing center
B	0005829	cellular_component	cytosol
B	0006000	biological_process	fructose metabolic process
B	0006001	biological_process	fructose catabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0008092	molecular_function	cytoskeletal protein binding
B	0016829	molecular_function	lyase activity
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0034451	cellular_component	centriolar satellite
B	0042802	molecular_function	identical protein binding
B	0051117	molecular_function	ATPase binding
B	0060090	molecular_function	molecular adaptor activity
B	0061609	molecular_function	fructose-1-phosphate aldolase activity
B	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
B	0070061	molecular_function	fructose binding
B	0070062	cellular_component	extracellular exosome
B	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
B	1905856	biological_process	negative regulation of pentose-phosphate shunt
C	0004332	molecular_function	fructose-bisphosphate aldolase activity
C	0005515	molecular_function	protein binding
C	0005815	cellular_component	microtubule organizing center
C	0005829	cellular_component	cytosol
C	0006000	biological_process	fructose metabolic process
C	0006001	biological_process	fructose catabolic process
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0008092	molecular_function	cytoskeletal protein binding
C	0016829	molecular_function	lyase activity
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0034451	cellular_component	centriolar satellite
C	0042802	molecular_function	identical protein binding
C	0051117	molecular_function	ATPase binding
C	0060090	molecular_function	molecular adaptor activity
C	0061609	molecular_function	fructose-1-phosphate aldolase activity
C	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
C	0070061	molecular_function	fructose binding
C	0070062	cellular_component	extracellular exosome
C	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
C	1905856	biological_process	negative regulation of pentose-phosphate shunt
D	0004332	molecular_function	fructose-bisphosphate aldolase activity
D	0005515	molecular_function	protein binding
D	0005815	cellular_component	microtubule organizing center
D	0005829	cellular_component	cytosol
D	0006000	biological_process	fructose metabolic process
D	0006001	biological_process	fructose catabolic process
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0008092	molecular_function	cytoskeletal protein binding
D	0016829	molecular_function	lyase activity
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0034451	cellular_component	centriolar satellite
D	0042802	molecular_function	identical protein binding
D	0051117	molecular_function	ATPase binding
D	0060090	molecular_function	molecular adaptor activity
D	0061609	molecular_function	fructose-1-phosphate aldolase activity
D	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
D	0070061	molecular_function	fructose binding
D	0070062	cellular_component	extracellular exosome
D	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
D	1905856	biological_process	negative regulation of pentose-phosphate shunt
W	0004332	molecular_function	fructose-bisphosphate aldolase activity
W	0005515	molecular_function	protein binding
W	0005815	cellular_component	microtubule organizing center
W	0005829	cellular_component	cytosol
W	0006000	biological_process	fructose metabolic process
W	0006001	biological_process	fructose catabolic process
W	0006094	biological_process	gluconeogenesis
W	0006096	biological_process	glycolytic process
W	0008092	molecular_function	cytoskeletal protein binding
W	0016829	molecular_function	lyase activity
W	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
W	0034451	cellular_component	centriolar satellite
W	0042802	molecular_function	identical protein binding
W	0051117	molecular_function	ATPase binding
W	0060090	molecular_function	molecular adaptor activity
W	0061609	molecular_function	fructose-1-phosphate aldolase activity
W	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
W	0070061	molecular_function	fructose binding
W	0070062	cellular_component	extracellular exosome
W	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
W	1905856	biological_process	negative regulation of pentose-phosphate shunt
X	0004332	molecular_function	fructose-bisphosphate aldolase activity
X	0005515	molecular_function	protein binding
X	0005815	cellular_component	microtubule organizing center
X	0005829	cellular_component	cytosol
X	0006000	biological_process	fructose metabolic process
X	0006001	biological_process	fructose catabolic process
X	0006094	biological_process	gluconeogenesis
X	0006096	biological_process	glycolytic process
X	0008092	molecular_function	cytoskeletal protein binding
X	0016829	molecular_function	lyase activity
X	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
X	0034451	cellular_component	centriolar satellite
X	0042802	molecular_function	identical protein binding
X	0051117	molecular_function	ATPase binding
X	0060090	molecular_function	molecular adaptor activity
X	0061609	molecular_function	fructose-1-phosphate aldolase activity
X	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
X	0070061	molecular_function	fructose binding
X	0070062	cellular_component	extracellular exosome
X	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
X	1905856	biological_process	negative regulation of pentose-phosphate shunt
Y	0004332	molecular_function	fructose-bisphosphate aldolase activity
Y	0005515	molecular_function	protein binding
Y	0005815	cellular_component	microtubule organizing center
Y	0005829	cellular_component	cytosol
Y	0006000	biological_process	fructose metabolic process
Y	0006001	biological_process	fructose catabolic process
Y	0006094	biological_process	gluconeogenesis
Y	0006096	biological_process	glycolytic process
Y	0008092	molecular_function	cytoskeletal protein binding
Y	0016829	molecular_function	lyase activity
Y	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
Y	0034451	cellular_component	centriolar satellite
Y	0042802	molecular_function	identical protein binding
Y	0051117	molecular_function	ATPase binding
Y	0060090	molecular_function	molecular adaptor activity
Y	0061609	molecular_function	fructose-1-phosphate aldolase activity
Y	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
Y	0070061	molecular_function	fructose binding
Y	0070062	cellular_component	extracellular exosome
Y	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
Y	1905856	biological_process	negative regulation of pentose-phosphate shunt
Z	0004332	molecular_function	fructose-bisphosphate aldolase activity
Z	0005515	molecular_function	protein binding
Z	0005815	cellular_component	microtubule organizing center
Z	0005829	cellular_component	cytosol
Z	0006000	biological_process	fructose metabolic process
Z	0006001	biological_process	fructose catabolic process
Z	0006094	biological_process	gluconeogenesis
Z	0006096	biological_process	glycolytic process
Z	0008092	molecular_function	cytoskeletal protein binding
Z	0016829	molecular_function	lyase activity
Z	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
Z	0034451	cellular_component	centriolar satellite
Z	0042802	molecular_function	identical protein binding
Z	0051117	molecular_function	ATPase binding
Z	0060090	molecular_function	molecular adaptor activity
Z	0061609	molecular_function	fructose-1-phosphate aldolase activity
Z	0061624	biological_process	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
Z	0070061	molecular_function	fructose binding
Z	0070062	cellular_component	extracellular exosome
Z	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
Z	1905856	biological_process	negative regulation of pentose-phosphate shunt

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 W 364

Chain	Residue
W	GLN202
W	THR254
W	ARG258
X	GLN9
X	LYS12

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 364

Chain	Residue
A	LYS12
B	GLN202
B	THR254
B	ARG258

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 X 364

Chain	Residue
W	LYS12
X	GLN202
X	ARG258

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 Y 364

Chain	Residue
Y	GLN202
Y	ARG258
Z	LYS12

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 364

Chain	Residue
C	GLN202
C	ARG258
D	LYS12

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 364

Chain	Residue
A	GLN202
A	THR254
A	ARG258
A	HOH368
B	GLN9
B	LYS12

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 365

Chain	Residue
C	GLN9
C	LYS12
C	HOH368
D	GLN202
D	THR254
D	ARG258

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Z 364

Chain	Residue
Y	GLN9
Y	LYS12
Z	GLN202
Z	ARG258
Z	HOH367

Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VyLEGtLLKPN

Chain	Residue	Details
A	VAL221-ASN231

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Schiff-base intermediate with dihydroxyacetone-P","evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q91Y97","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	48
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00884","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
A	GLU187
A	LYS229
A	ASP33

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
B	GLU187
B	LYS229
B	ASP33

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
C	GLU187
C	LYS229
C	ASP33

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
D	GLU187
D	LYS229
D	ASP33

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
W	GLU187
W	LYS229
W	ASP33

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
X	GLU187
X	LYS229
X	ASP33

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
Y	GLU187
Y	LYS229
Y	ASP33

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
Z	GLU187
Z	LYS229
Z	ASP33

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)