1XA6

Crystal Structure of the Human Beta2-Chimaerin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001675	biological_process	acrosome assembly
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0007165	biological_process	signal transduction
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0043547	biological_process	positive regulation of GTPase activity
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0051056	biological_process	regulation of small GTPase mediated signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 467

Chain	Residue
A	HIS213
A	CYS243
A	CYS246
A	CYS262

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 468

Chain	Residue
A	CYS226
A	CYS229
A	HIS251
A	CYS254

---

Functional Information from PROSITE/UniProt

site_id	PS00479
Number of Residues	50
Details	ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFkvhtfrgphw.CeyCanfMwgliaqgvr.CsdCglnvHkqCskhvpnd..C

Chain	Residue	Details
A	HIS213-CYS262

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	191
Details	Domain: {"description":"Rho-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	50
Details	Zinc finger: {"description":"Phorbol-ester/DAG-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00226","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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