1X9Y

The prostaphopain B structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0016787	molecular_function	hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LGHALAVVGNA

Chain	Residue	Details
A	LEU338-ALA348

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"evidences":[{"source":"PubMed","id":"15644332","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed Harrison1997, 12874290, 15518582, 15644332, 11518582

Chain	Residue	Details
A	HIS340
A	CYS243
A	CYS243
A	GLN237
A	ASN360

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site_id	CSA2
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed Harrison1997, 12874290, 15518582, 15644332, 11518582

Chain	Residue	Details
B	HIS340
B	CYS243
B	CYS243
B	GLN237
B	ASN360

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site_id	CSA3
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed Harrison1997, 12874290, 15518582, 15644332, 11518582

Chain	Residue	Details
C	HIS340
C	CYS243
C	CYS243
C	GLN237
C	ASN360

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site_id	CSA4
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed Harrison1997, 12874290, 15518582, 15644332, 11518582

Chain	Residue	Details
D	HIS340
D	CYS243
D	CYS243
D	GLN237
D	ASN360

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 805

Chain	Residue	Details
A	GLN237	electrostatic stabiliser
A	CYS243	nucleofuge, nucleophile, proton acceptor, proton donor
A	HIS340	proton acceptor, proton donor
A	ASN360	electrostatic stabiliser, modifies pKa

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 805

Chain	Residue	Details
B	GLN237	electrostatic stabiliser
B	CYS243	nucleofuge, nucleophile, proton acceptor, proton donor
B	HIS340	proton acceptor, proton donor
B	ASN360	electrostatic stabiliser, modifies pKa

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site_id	MCSA3
Number of Residues	4
Details	M-CSA 805

Chain	Residue	Details
C	GLN237	electrostatic stabiliser
C	CYS243	nucleofuge, nucleophile, proton acceptor, proton donor
C	HIS340	proton acceptor, proton donor
C	ASN360	electrostatic stabiliser, modifies pKa

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site_id	MCSA4
Number of Residues	4
Details	M-CSA 805

Chain	Residue	Details
D	GLN237	electrostatic stabiliser
D	CYS243	nucleofuge, nucleophile, proton acceptor, proton donor
D	HIS340	proton acceptor, proton donor
D	ASN360	electrostatic stabiliser, modifies pKa

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