Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1X9J

Structure of butyrate kinase 2 reveals both open- and citrate-induced closed conformations: implications for substrate-induced fit conformational changes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006083	biological_process	acetate metabolic process
A	0008776	molecular_function	acetate kinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
A	0047761	molecular_function	butyrate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006083	biological_process	acetate metabolic process
B	0008776	molecular_function	acetate kinase activity
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
B	0047761	molecular_function	butyrate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006083	biological_process	acetate metabolic process
C	0008776	molecular_function	acetate kinase activity
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
C	0047761	molecular_function	butyrate kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006083	biological_process	acetate metabolic process
D	0008776	molecular_function	acetate kinase activity
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
D	0047761	molecular_function	butyrate kinase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006083	biological_process	acetate metabolic process
E	0008776	molecular_function	acetate kinase activity
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
E	0047761	molecular_function	butyrate kinase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006083	biological_process	acetate metabolic process
F	0008776	molecular_function	acetate kinase activity
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
F	0047761	molecular_function	butyrate kinase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006083	biological_process	acetate metabolic process
G	0008776	molecular_function	acetate kinase activity
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
G	0047761	molecular_function	butyrate kinase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006083	biological_process	acetate metabolic process
H	0008776	molecular_function	acetate kinase activity
H	0016301	molecular_function	kinase activity
H	0016310	biological_process	phosphorylation
H	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
H	0047761	molecular_function	butyrate kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA D 380

Chain	Residue
D	VAL58
D	GLU59
D	THR61
D	TYR63
E	GLU119

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 E 401

Chain	Residue
E	TRP284
E	LYS287
D	THR217
D	TRP284
D	LYS287
E	THR217

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 402

Chain	Residue
B	THR217
B	TRP284
B	LYS287
C	ASP207
C	THR217
C	TRP284
C	LYS287

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 F 403

Chain	Residue
F	ASP207
F	THR217
F	TRP284
F	LYS287
G	THR217
G	TRP284
G	LYS287

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 H 404

Chain	Residue
A	ASP207
A	THR217
A	TRP284
A	LYS287
H	THR217
H	TRP284
H	LYS287

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 405

Chain	Residue
D	ARG55
E	LYS97
E	HIS114
E	ARG115

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT D 381

Chain	Residue
D	SER11
D	HIS104
D	HIS154
D	HIS182
D	GLY184
D	GLY185
D	GLY186
D	LEU204
D	ARG214

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT G 382

Chain	Residue
G	SER11
G	HIS104
G	VAL130
G	HIS154
G	GLY184
G	GLY185
G	GLY186
G	ARG214
G	CIT383

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT G 383

Chain	Residue
G	LYS15
G	HIS182
G	GLY304
G	HIS307
G	GLY331
G	SER332
G	CIT382

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT D 384

Chain	Residue
D	SER13
D	LYS15
D	ASN29
D	GLY304
D	GLY331
D	SER332

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL F 391

Chain	Residue
F	MET1
F	ARG3
F	PHE68

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 392

Chain	Residue
C	MET1
C	ARG3
C	SER67
C	PHE68
C	SER69

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 393

Chain	Residue
D	MET1
D	ARG3
D	PHE68
D	SER69

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 394

Chain	Residue
B	HIS307
B	GLY331
B	SER332

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 395

Chain	Residue
A	VAL130
A	HIS154
A	ARG214

Functional Information from PROSITE/UniProt

site_id	PS01075
Number of Residues	12
Details	ACETATE_KINASE_1 Acetate and butyrate kinases family signature 1. ILtINpGSTStK

Chain	Residue	Details
A	ILE4-LYS15

site_id	PS01076
Number of Residues	18
Details	ACETATE_KINASE_2 Acetate and butyrate kinases family signature 2. LVvaHmGgGiSIaAhrkG

Chain	Residue	Details
A	LEU178-GLY195

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)