1X9E
Crystal structure of HMG-CoA synthase from Enterococcus faecalis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 384 |
| Chain | Residue |
| A | LYS7 |
| A | THR64 |
| A | ARG167 |
| A | HOH402 |
| A | HOH444 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 384 |
| Chain | Residue |
| B | LYS7 |
| B | THR64 |
| B | ARG167 |
| B | HOH468 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 385 |
| Chain | Residue |
| A | CYS111 |
| A | TYR143 |
| A | HIS233 |
| A | PRO235 |
| A | ASN275 |
| A | TYR277 |
| A | SER308 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 385 |
| Chain | Residue |
| B | CYS111 |
| B | HIS233 |
| B | PRO235 |
| B | ASN275 |
| B | TYR277 |
| B | SER308 |
| B | HOH404 |
| B | HOH413 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"16245942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P54868","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
