1X8X

Tyrosyl t-RNA Synthetase from E.coli Complexed with Tyrosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 951

Chain	Residue
A	THR43
A	HIS48
A	HIS51
A	LYS85
A	ARG89
A	HOH832

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TYR A 952

Chain	Residue
A	ASP81
A	TYR175
A	GLN179
A	ASP182
A	GLN195
A	GLN201
A	HOH648
A	HOH653
A	HOH658
A	HOH665
A	HOH715
A	HOH869
A	TYR37
A	GLY39
A	ASP41

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Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	11
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pt.ADsLHLGHL

Chain	Residue	Details
A	PRO42-LEU52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000305|PubMed:15671170

Chain	Residue	Details
A	CYS38

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000269|PubMed:15671170, ECO:0000305|PubMed:20159998

Chain	Residue	Details
A	ASN176
A	GLY180

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006

Chain	Residue	Details
A	THR239

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cross-linked with tRNA by periodate oxidation

Chain	Residue	Details
A	ASP232
A	THR239

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Cross-linked with tRNA by periodate oxidation; predominant

Chain	Residue	Details
A	PHE236

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
A	HIS145

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