1X8H

The Mono-Zinc Carbapenemase CphA (N220G mutant) Shows a Zn(II)- NH2 ARG Coordination

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CO32
A	ASP120
A	ARG121
A	CYS221
A	HIS263

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CO3 A 2

Chain	Residue
A	HIS263
A	ZN401
A	HOH403
A	HOH404
A	HOH410
A	ASP120
A	HIS196
A	CYS221
A	LYS224

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	ARG143
A	ARG143
A	LYS147
A	LYS147
A	HOH560
A	HOH561

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 4

Chain	Residue
A	ARG140
A	ARG140
A	HOH496
A	HOH601

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 5

Chain	Residue
A	LYS97
A	ARG102
A	LYS257
A	HOH446
A	HOH451
A	HOH637

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 6

Chain	Residue
A	HIS176
A	ASP177
A	GLY178
A	ASP179
A	HOH642

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 7

Chain	Residue
A	LEU267
A	HIS289
A	GLY290
A	GLU292
A	HOH566
A	HOH645

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	20
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. InTNyHTDraGGnaywksi.G

Chain	Residue	Details
A	ILE113-GLY133

---

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PdeqVLyGgCILK

Chain	Residue	Details
A	PRO209-LYS224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:18563261, ECO:0000269|PubMed:19651913, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	ASP120
A	CYS221
A	HIS263

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826

Chain	Residue	Details
A	THR157

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:18563261, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	HIS196

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	LYS224

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:18563261

Chain	Residue	Details
A	ASN233

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120
A	ASN233

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120

---