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1X3N

Crystal structure of AMPPNP bound Propionate kinase (TdcD) from Salmonella typhimurium

Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0005829cellular_componentcytosol
A0006082biological_processorganic acid metabolic process
A0006083biological_processacetate metabolic process
A0008776molecular_functionacetate kinase activity
A0008980molecular_functionpropionate kinase activity
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016774molecular_functionphosphotransferase activity, carboxyl group as acceptor
A0046872molecular_functionmetal ion binding
A0070689biological_processL-threonine catabolic process to propionate
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 403
ChainResidue
AALA115
AHIS118
APRO227
AHOH554

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ANP A 404
ChainResidue
ALEU279
AARG280
AGLU283
AGLY326
AILE327
AASN330
AHOH546
AHOH552
AHOH556
AHIS175
AGLY205
AASN206
AGLY207
AASP278

Functional Information from PROSITE/UniProt
site_idPS01075
Number of Residues12
DetailsACETATE_KINASE_1 Acetate and butyrate kinases family signature 1. VLvINcGSSSiK
ChainResidueDetails
AVAL7-LYS18

site_idPS01076
Number of Residues18
DetailsACETATE_KINASE_2 Acetate and butyrate kinases family signature 2. LIvaHlGnGaSIcAvrnG
ChainResidueDetails
ALEU199-GLY216

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_01881
ChainResidueDetails
AASP143

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01881
ChainResidueDetails
AASN11
ALYS18
AARG86
AGLY326
AGLU381

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING:
ChainResidueDetails
AHIS175
AHIS203
AASP278

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_01881
ChainResidueDetails
AHIS175
AARG236

Catalytic Information from CSA
site_idCSA1
Number of Residues5
DetailsAnnotated By Reference To The Literature 1g99
ChainResidueDetails
AGLY207
AARG236
AASP143
ASER14
AARG86

226707

PDB entries from 2024-10-30

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