1X23

Crystal structure of ubch5c

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005768	cellular_component	endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006281	biological_process	DNA repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0010008	cellular_component	endosome membrane
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0030514	biological_process	negative regulation of BMP signaling pathway
A	0036211	biological_process	protein modification process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0085020	biological_process	protein K6-linked ubiquitination
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005768	cellular_component	endosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006281	biological_process	DNA repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006513	biological_process	protein monoubiquitination
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0010008	cellular_component	endosome membrane
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0030514	biological_process	negative regulation of BMP signaling pathway
B	0036211	biological_process	protein modification process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051865	biological_process	protein autoubiquitination
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070062	cellular_component	extracellular exosome
B	0070936	biological_process	protein K48-linked ubiquitination
B	0070979	biological_process	protein K11-linked ubiquitination
B	0085020	biological_process	protein K6-linked ubiquitination
B	1903955	biological_process	positive regulation of protein targeting to mitochondrion
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000166	molecular_function	nucleotide binding
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005768	cellular_component	endosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0010008	cellular_component	endosome membrane
C	0016020	cellular_component	membrane
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0030514	biological_process	negative regulation of BMP signaling pathway
C	0036211	biological_process	protein modification process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051865	biological_process	protein autoubiquitination
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0070062	cellular_component	extracellular exosome
C	0070936	biological_process	protein K48-linked ubiquitination
C	0070979	biological_process	protein K11-linked ubiquitination
C	0085020	biological_process	protein K6-linked ubiquitination
C	1903955	biological_process	positive regulation of protein targeting to mitochondrion
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000166	molecular_function	nucleotide binding
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005768	cellular_component	endosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0010008	cellular_component	endosome membrane
D	0016020	cellular_component	membrane
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0030514	biological_process	negative regulation of BMP signaling pathway
D	0036211	biological_process	protein modification process
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051865	biological_process	protein autoubiquitination
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061631	molecular_function	ubiquitin conjugating enzyme activity
D	0070062	cellular_component	extracellular exosome
D	0070936	biological_process	protein K48-linked ubiquitination
D	0070979	biological_process	protein K11-linked ubiquitination
D	0085020	biological_process	protein K6-linked ubiquitination
D	1903955	biological_process	positive regulation of protein targeting to mitochondrion

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL

Chain	Residue	Details
A	TYR74-LEU89

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	584
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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