1X0X
Co-Structure of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 complex with NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006127 | biological_process | glycerol-3-phosphate shuttle |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045821 | biological_process | positive regulation of glycolytic process |
| A | 0046168 | biological_process | glycerol-3-phosphate catabolic process |
| A | 0047952 | molecular_function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071320 | biological_process | cellular response to cAMP |
| A | 0071356 | biological_process | cellular response to tumor necrosis factor |
| A | 0141152 | molecular_function | glycerol-3-phosphate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | LYS20 |
| A | HIS67 |
| A | LYS68 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
| Chain | Residue |
| A | HOH2010 |
| A | HOH2022 |
| A | HOH2039 |
| A | HOH2049 |
| A | HOH2076 |
| A | HOH2134 |
| A | LYS204 |
| A | ASN205 |
| A | THR264 |
| A | GLY268 |
| A | ARG269 |
| A | ASN270 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | LYS240 |
| A | VAL247 |
| A | SER248 |
| A | SER249 |
| A | HOH2175 |
| A | HOH2179 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | ARG271 |
| A | LYS272 |
| A | HOH2017 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | ASN13 |
| A | GLN295 |
| A | HOH2065 |
| A | HOH2096 |
| A | HOH2211 |
| site_id | AC6 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD A 2001 |
| Chain | Residue |
| A | SER11 |
| A | GLY12 |
| A | ASN13 |
| A | TRP14 |
| A | GLY15 |
| A | PHE41 |
| A | TYR63 |
| A | VAL93 |
| A | PRO94 |
| A | PHE97 |
| A | ILE119 |
| A | LYS120 |
| A | ASN151 |
| A | ALA153 |
| A | ARG269 |
| A | GLY294 |
| A | GLN295 |
| A | LYS296 |
| A | GLN298 |
| A | HOH2007 |
| A | HOH2011 |
| A | HOH2012 |
| A | HOH2022 |
| A | HOH2023 |
| A | HOH2039 |
| A | HOH2044 |
| A | HOH2087 |
| A | HOH2134 |
| A | HOH2135 |
Functional Information from PROSITE/UniProt
| site_id | PS00957 |
| Number of Residues | 22 |
| Details | NAD_G3PDH NAD-dependent glycerol-3-phosphate dehydrogenase signature. GALKNVVAvGaGFcdGLgFGdN |
| Chain | Residue | Details |
| A | GLY201-ASN222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16460752","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P13707","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O35077","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1evy |
| Chain | Residue | Details |
| A | LYS204 | |
| A | THR264 |
