1X0X

Co-Structure of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 complex with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004368	molecular_function	glycerol-3-phosphate dehydrogenase (quinone) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006072	biological_process	glycerol-3-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006116	biological_process	NADH oxidation
A	0006127	biological_process	glycerophosphate shuttle
A	0006734	biological_process	NADH metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0042803	molecular_function	protein homodimerization activity
A	0045821	biological_process	positive regulation of glycolytic process
A	0046168	biological_process	glycerol-3-phosphate catabolic process
A	0046486	biological_process	glycerolipid metabolic process
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
A	0071320	biological_process	cellular response to cAMP
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0141152	molecular_function	glycerol-3-phosphate dehydrogenase (NAD+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	LYS20
A	HIS67
A	LYS68

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	HOH2010
A	HOH2022
A	HOH2039
A	HOH2049
A	HOH2076
A	HOH2134
A	LYS204
A	ASN205
A	THR264
A	GLY268
A	ARG269
A	ASN270

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	LYS240
A	VAL247
A	SER248
A	SER249
A	HOH2175
A	HOH2179

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	ARG271
A	LYS272
A	HOH2017

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	ASN13
A	GLN295
A	HOH2065
A	HOH2096
A	HOH2211

---

site_id	AC6
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAD A 2001

Chain	Residue
A	SER11
A	GLY12
A	ASN13
A	TRP14
A	GLY15
A	PHE41
A	TYR63
A	VAL93
A	PRO94
A	PHE97
A	ILE119
A	LYS120
A	ASN151
A	ALA153
A	ARG269
A	GLY294
A	GLN295
A	LYS296
A	GLN298
A	HOH2007
A	HOH2011
A	HOH2012
A	HOH2022
A	HOH2023
A	HOH2039
A	HOH2044
A	HOH2087
A	HOH2134
A	HOH2135

---

Functional Information from PROSITE/UniProt

site_id	PS00957
Number of Residues	22
Details	NAD_G3PDH NAD-dependent glycerol-3-phosphate dehydrogenase signature. GALKNVVAvGaGFcdGLgFGdN

Chain	Residue	Details
A	GLY201-ASN222

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305

Chain	Residue	Details
A	LYS204

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:16460752

Chain	Residue	Details
A	GLY10
A	PHE41
A	PHE97
A	ALA153
A	ARG269
A	LYS296
A	GLN298

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS120

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER154

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P13707

Chain	Residue	Details
A	LYS289

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O35077

Chain	Residue	Details
A	TYR326

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1evy

Chain	Residue	Details
A	LYS204
A	THR264

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