1X0R
Thioredoxin Peroxidase from Aeropyrum pernix K1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008379 | molecular_function | thioredoxin peroxidase activity |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0051920 | molecular_function | peroxiredoxin activity |
| A | 0055114 | biological_process | obsolete oxidation-reduction process |
| A | 0070301 | biological_process | cellular response to hydrogen peroxide |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008379 | molecular_function | thioredoxin peroxidase activity |
| B | 0016209 | molecular_function | antioxidant activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0033554 | biological_process | cellular response to stress |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0051920 | molecular_function | peroxiredoxin activity |
| B | 0055114 | biological_process | obsolete oxidation-reduction process |
| B | 0070301 | biological_process | cellular response to hydrogen peroxide |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0008379 | molecular_function | thioredoxin peroxidase activity |
| C | 0016209 | molecular_function | antioxidant activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0033554 | biological_process | cellular response to stress |
| C | 0042744 | biological_process | hydrogen peroxide catabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0045454 | biological_process | cell redox homeostasis |
| C | 0051920 | molecular_function | peroxiredoxin activity |
| C | 0055114 | biological_process | obsolete oxidation-reduction process |
| C | 0070301 | biological_process | cellular response to hydrogen peroxide |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0008379 | molecular_function | thioredoxin peroxidase activity |
| D | 0016209 | molecular_function | antioxidant activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0033554 | biological_process | cellular response to stress |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0045454 | biological_process | cell redox homeostasis |
| D | 0051920 | molecular_function | peroxiredoxin activity |
| D | 0055114 | biological_process | obsolete oxidation-reduction process |
| D | 0070301 | biological_process | cellular response to hydrogen peroxide |
| D | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| E | 0004601 | molecular_function | peroxidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006979 | biological_process | response to oxidative stress |
| E | 0008379 | molecular_function | thioredoxin peroxidase activity |
| E | 0016209 | molecular_function | antioxidant activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0033554 | biological_process | cellular response to stress |
| E | 0042744 | biological_process | hydrogen peroxide catabolic process |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0045454 | biological_process | cell redox homeostasis |
| E | 0051920 | molecular_function | peroxiredoxin activity |
| E | 0055114 | biological_process | obsolete oxidation-reduction process |
| E | 0070301 | biological_process | cellular response to hydrogen peroxide |
| E | 0098869 | biological_process | cellular oxidant detoxification |
| E | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| F | 0004601 | molecular_function | peroxidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006979 | biological_process | response to oxidative stress |
| F | 0008379 | molecular_function | thioredoxin peroxidase activity |
| F | 0016209 | molecular_function | antioxidant activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0033554 | biological_process | cellular response to stress |
| F | 0042744 | biological_process | hydrogen peroxide catabolic process |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0045454 | biological_process | cell redox homeostasis |
| F | 0051920 | molecular_function | peroxiredoxin activity |
| F | 0055114 | biological_process | obsolete oxidation-reduction process |
| F | 0070301 | biological_process | cellular response to hydrogen peroxide |
| F | 0098869 | biological_process | cellular oxidant detoxification |
| F | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| G | 0004601 | molecular_function | peroxidase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006979 | biological_process | response to oxidative stress |
| G | 0008379 | molecular_function | thioredoxin peroxidase activity |
| G | 0016209 | molecular_function | antioxidant activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0033554 | biological_process | cellular response to stress |
| G | 0042744 | biological_process | hydrogen peroxide catabolic process |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0045454 | biological_process | cell redox homeostasis |
| G | 0051920 | molecular_function | peroxiredoxin activity |
| G | 0055114 | biological_process | obsolete oxidation-reduction process |
| G | 0070301 | biological_process | cellular response to hydrogen peroxide |
| G | 0098869 | biological_process | cellular oxidant detoxification |
| G | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| H | 0004601 | molecular_function | peroxidase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006979 | biological_process | response to oxidative stress |
| H | 0008379 | molecular_function | thioredoxin peroxidase activity |
| H | 0016209 | molecular_function | antioxidant activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0033554 | biological_process | cellular response to stress |
| H | 0042744 | biological_process | hydrogen peroxide catabolic process |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0045454 | biological_process | cell redox homeostasis |
| H | 0051920 | molecular_function | peroxiredoxin activity |
| H | 0055114 | biological_process | obsolete oxidation-reduction process |
| H | 0070301 | biological_process | cellular response to hydrogen peroxide |
| H | 0098869 | biological_process | cellular oxidant detoxification |
| H | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| I | 0004601 | molecular_function | peroxidase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0006979 | biological_process | response to oxidative stress |
| I | 0008379 | molecular_function | thioredoxin peroxidase activity |
| I | 0016209 | molecular_function | antioxidant activity |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0033554 | biological_process | cellular response to stress |
| I | 0042744 | biological_process | hydrogen peroxide catabolic process |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0045454 | biological_process | cell redox homeostasis |
| I | 0051920 | molecular_function | peroxiredoxin activity |
| I | 0055114 | biological_process | obsolete oxidation-reduction process |
| I | 0070301 | biological_process | cellular response to hydrogen peroxide |
| I | 0098869 | biological_process | cellular oxidant detoxification |
| I | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| J | 0004601 | molecular_function | peroxidase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006979 | biological_process | response to oxidative stress |
| J | 0008379 | molecular_function | thioredoxin peroxidase activity |
| J | 0016209 | molecular_function | antioxidant activity |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0033554 | biological_process | cellular response to stress |
| J | 0042744 | biological_process | hydrogen peroxide catabolic process |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0045454 | biological_process | cell redox homeostasis |
| J | 0051920 | molecular_function | peroxiredoxin activity |
| J | 0055114 | biological_process | obsolete oxidation-reduction process |
| J | 0070301 | biological_process | cellular response to hydrogen peroxide |
| J | 0098869 | biological_process | cellular oxidant detoxification |
| J | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2001 |
| Chain | Residue |
| A | ARG232 |
| A | GLU235 |
| A | HOH2215 |
| B | GLU179 |
| F | ARG66 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 2002 |
| Chain | Residue |
| B | EDO2021 |
| B | HOH2153 |
| A | GLU179 |
| B | ARG232 |
| B | GLU235 |
| B | PRO237 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 2003 |
| Chain | Residue |
| C | GLU179 |
| D | ARG232 |
| D | GLU235 |
| D | HOH2206 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 2004 |
| Chain | Residue |
| C | ARG232 |
| C | GLU235 |
| C | HOH2263 |
| D | GLU179 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 2005 |
| Chain | Residue |
| E | ARG232 |
| E | GLU235 |
| E | HOH513 |
| F | GLU179 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO F 2006 |
| Chain | Residue |
| A | ARG66 |
| E | GLU179 |
| F | ARG232 |
| F | GLU235 |
| F | HOH504 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO I 2007 |
| Chain | Residue |
| D | ARG66 |
| I | ARG232 |
| I | GLU235 |
| I | HOH2207 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO J 2008 |
| Chain | Residue |
| I | GLU179 |
| J | ARG232 |
| J | GLU235 |
| J | HOH2225 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO G 2009 |
| Chain | Residue |
| G | ARG232 |
| G | GLU235 |
| G | HOH1164 |
| H | GLU179 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO H 2010 |
| Chain | Residue |
| G | GLU179 |
| H | ARG232 |
| H | GLU235 |
| H | HOH1165 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 2011 |
| Chain | Residue |
| A | HIS21 |
| A | HIS29 |
| A | HOH2139 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 2012 |
| Chain | Residue |
| A | THR47 |
| A | PRO48 |
| A | VAL49 |
| A | CYS50 |
| A | ARG126 |
| A | MSE145 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2013 |
| Chain | Residue |
| B | THR191 |
| B | HOH2141 |
| J | THR18 |
| J | PHE80 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO J 2014 |
| Chain | Residue |
| J | GLU87 |
| J | TRP88 |
| J | ARG91 |
| J | HIS92 |
| J | HOH2211 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2015 |
| Chain | Residue |
| B | GLU193 |
| B | ALA196 |
| B | ARG197 |
| J | GLU87 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 2016 |
| Chain | Residue |
| A | TRP36 |
| A | ASP132 |
| A | ALA133 |
| A | ASP165 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2017 |
| Chain | Residue |
| A | ARG228 |
| A | ARG231 |
| A | GLU235 |
| F | ARG66 |
| F | ARG228 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 2018 |
| Chain | Residue |
| B | LEU163 |
| B | PRO217 |
| B | ALA218 |
| B | SER219 |
| B | ASP222 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 2019 |
| Chain | Residue |
| A | GLU87 |
| I | GLU193 |
| I | ALA196 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 2020 |
| Chain | Residue |
| B | GLN195 |
| B | ARG199 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2021 |
| Chain | Residue |
| B | PRO237 |
| B | ALA238 |
| B | LYS239 |
| B | EDO2002 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2022 |
| Chain | Residue |
| A | ILE181 |
| A | GLY182 |
| A | GLU183 |
| B | LYS236 |
| B | LEU240 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 2023 |
| Chain | Residue |
| B | VAL109 |
| B | VAL17 |
| B | THR18 |
| B | ILE102 |
| B | ALA103 |
| B | ASP104 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 2024 |
| Chain | Residue |
| C | THR47 |
| C | PRO48 |
| C | VAL49 |
| C | CYS50 |
| C | ARG126 |
| C | MSE145 |
| C | EDO2067 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 2025 |
| Chain | Residue |
| B | TRP36 |
| B | ASP132 |
| B | ALA133 |
| B | ARG134 |
| B | ASP165 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 2026 |
| Chain | Residue |
| C | VAL17 |
| C | THR18 |
| C | ILE102 |
| C | ALA103 |
| C | VAL109 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2027 |
| Chain | Residue |
| B | ASP63 |
| B | GLU225 |
| B | ARG228 |
| B | ARG232 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 2028 |
| Chain | Residue |
| B | THR47 |
| B | PRO48 |
| B | VAL49 |
| B | CYS50 |
| B | ARG126 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 2029 |
| Chain | Residue |
| A | ASP209 |
| A | HOH2218 |
| B | TRP88 |
| B | HIS92 |
| B | EDO2125 |
| C | LYS84 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 2030 |
| Chain | Residue |
| B | ARG199 |
| B | MSE200 |
| B | GLY203 |
| B | GLN204 |
| B | TYR205 |
| B | SER207 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 2031 |
| Chain | Residue |
| D | TRP36 |
| D | ASP132 |
| D | ALA133 |
| D | ARG134 |
| D | ASP165 |
| D | HOH2136 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 2032 |
| Chain | Residue |
| D | THR18 |
| D | HOH2228 |
| E | HIS123 |
| E | HOH938 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 2033 |
| Chain | Residue |
| D | GLU62 |
| D | GLN65 |
| D | ARG66 |
| D | EDO2073 |
| I | PRO237 |
| I | ALA238 |
| I | LYS239 |
| site_id | DC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO F 2034 |
| Chain | Residue |
| F | ARG199 |
| F | MSE200 |
| F | SER202 |
| F | GLY203 |
| F | GLN204 |
| F | TYR205 |
| F | SER207 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 2035 |
| Chain | Residue |
| D | ARG199 |
| D | MSE200 |
| D | SER202 |
| D | GLY203 |
| D | GLN204 |
| D | TYR205 |
| D | SER207 |
| site_id | DC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 2036 |
| Chain | Residue |
| C | LEU163 |
| C | LEU167 |
| C | ALA218 |
| C | SER219 |
| C | ASP222 |
| C | HOH2257 |
| H | SER166 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO F 2037 |
| Chain | Residue |
| E | THR191 |
| F | THR122 |
| F | HIS123 |
| F | EDO2086 |
| G | PHE80 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO F 2038 |
| Chain | Residue |
| F | THR18 |
| F | VAL79 |
| F | PHE80 |
| F | HOH466 |
| G | HIS123 |
| H | THR191 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 2039 |
| Chain | Residue |
| E | TRP36 |
| E | ASP132 |
| E | ALA133 |
| E | ARG134 |
| E | ASP165 |
| E | HOH478 |
| site_id | EC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO E 2040 |
| Chain | Residue |
| E | ARG59 |
| E | ARG232 |
| F | GLU179 |
| site_id | EC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO E 2041 |
| Chain | Residue |
| E | ILE181 |
| E | GLY182 |
| E | GLU183 |
| E | GLY184 |
| E | THR216 |
| E | HOH1154 |
| F | LEU240 |
| site_id | EC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO E 2042 |
| Chain | Residue |
| E | ARG199 |
| E | MSE200 |
| E | GLY203 |
| E | GLN204 |
| E | TYR205 |
| E | SER207 |
| E | EDO2090 |
| site_id | EC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO F 2043 |
| Chain | Residue |
| E | LYS236 |
| E | LEU240 |
| F | ILE181 |
| F | GLY182 |
| F | GLU183 |
| F | GLY184 |
| F | TRP214 |
| F | THR216 |
| site_id | EC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO H 2044 |
| Chain | Residue |
| H | VAL17 |
| H | THR18 |
| H | ILE102 |
| H | ALA103 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO I 2045 |
| Chain | Residue |
| I | TRP36 |
| I | ASP132 |
| I | ALA133 |
| I | ARG134 |
| I | ASP165 |
| I | HOH2213 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO I 2046 |
| Chain | Residue |
| I | MSE15 |
| I | THR108 |
| I | ARG112 |
| I | HOH2169 |
| site_id | FC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO G 2047 |
| Chain | Residue |
| G | ARG199 |
| G | MSE200 |
| G | SER202 |
| G | GLY203 |
| G | GLN204 |
| G | TYR205 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO J 2048 |
| Chain | Residue |
| J | GLY164 |
| J | ARG169 |
| J | PRO188 |
| J | HOH2159 |
| site_id | FC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO J 2049 |
| Chain | Residue |
| J | ASP63 |
| J | GLU225 |
| J | ARG228 |
| J | ARG232 |
| site_id | FC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO G 2050 |
| Chain | Residue |
| G | ALA196 |
| G | ARG197 |
| G | MSE200 |
| G | TRP210 |
| I | GLU87 |
| site_id | FC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO I 2051 |
| Chain | Residue |
| I | ARG199 |
| I | MSE200 |
| I | SER202 |
| I | GLY203 |
| I | GLN204 |
| I | TYR205 |
| site_id | FC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO I 2052 |
| Chain | Residue |
| D | ARG66 |
| D | ARG228 |
| D | HOH2164 |
| I | ARG228 |
| I | ARG232 |
| I | GLU235 |
| site_id | FC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO J 2053 |
| Chain | Residue |
| J | MSE15 |
| J | GLU16 |
| J | THR108 |
| J | ARG112 |
| site_id | FC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO H 2054 |
| Chain | Residue |
| H | ILE83 |
| H | GLU87 |
| H | HOH1173 |
| J | GLU193 |
| J | ALA196 |
| J | ARG197 |
| site_id | GC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO J 2055 |
| Chain | Residue |
| J | ARG199 |
| J | MSE200 |
| J | SER202 |
| J | GLY203 |
| J | GLN204 |
| J | TYR205 |
| site_id | GC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO G 2056 |
| Chain | Residue |
| G | THR47 |
| G | PRO48 |
| G | VAL49 |
| G | CYS50 |
| G | ARG126 |
| G | MSE145 |
| G | HOH1153 |
| site_id | GC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO G 2057 |
| Chain | Residue |
| G | ILE181 |
| G | GLY182 |
| G | GLU183 |
| H | LEU240 |
| site_id | GC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO H 2058 |
| Chain | Residue |
| G | LEU240 |
| H | ILE181 |
| H | GLY182 |
| H | GLU183 |
| site_id | GC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO H 2059 |
| Chain | Residue |
| H | VAL95 |
| H | ARG96 |
| H | HOH1074 |
| site_id | GC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO H 2060 |
| Chain | Residue |
| H | ARG199 |
| H | MSE200 |
| H | SER202 |
| H | GLY203 |
| H | GLN204 |
| H | TYR205 |
| H | SER207 |
| H | CYS213 |
| site_id | GC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO J 2061 |
| Chain | Residue |
| J | VAL17 |
| J | THR18 |
| J | ILE102 |
| J | ALA103 |
| J | VAL109 |
| J | EDO2123 |
| site_id | GC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 2062 |
| Chain | Residue |
| B | GLU87 |
| D | GLU193 |
| D | HOH2120 |
| site_id | GC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2063 |
| Chain | Residue |
| A | GLU183 |
| A | THR216 |
| A | ALA218 |
| A | HOH2191 |
| A | HOH2192 |
| site_id | HC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 2064 |
| Chain | Residue |
| C | HIS21 |
| C | HIS29 |
| C | HOH2254 |
| site_id | HC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 2065 |
| Chain | Residue |
| A | ARG199 |
| A | MSE200 |
| A | GLY203 |
| A | GLN204 |
| A | TYR205 |
| A | SER207 |
| A | CYS213 |
| site_id | HC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 2066 |
| Chain | Residue |
| A | ARG59 |
| A | LYS239 |
| A | LEU241 |
| A | GLU244 |
| A | HOH2246 |
| F | GLN65 |
| site_id | HC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 2067 |
| Chain | Residue |
| C | PRO43 |
| C | THR47 |
| C | MSE145 |
| C | EDO2024 |
| D | PRO189 |
| site_id | HC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO J 2068 |
| Chain | Residue |
| J | HIS21 |
| J | HIS29 |
| J | PRO100 |
| J | HOH2133 |
| J | HOH2135 |
| site_id | HC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO J 2069 |
| Chain | Residue |
| J | TRP36 |
| J | ASP132 |
| J | ALA133 |
| J | ARG134 |
| J | ASP165 |
| J | HOH2143 |
| site_id | HC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2070 |
| Chain | Residue |
| B | GLY203 |
| B | GLN204 |
| B | TYR205 |
| I | SER32 |
| site_id | HC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 2071 |
| Chain | Residue |
| D | ARG11 |
| D | VAL31 |
| D | ARG134 |
| E | SER166 |
| E | LEU167 |
| site_id | HC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 2072 |
| Chain | Residue |
| D | ARG228 |
| D | ARG231 |
| D | ARG232 |
| D | GLU235 |
| D | HOH2171 |
| I | ARG228 |
| I | EDO2107 |
| site_id | IC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 2073 |
| Chain | Residue |
| D | GLN65 |
| D | EDO2033 |
| I | LYS239 |
| I | LEU241 |
| I | GLU244 |
| site_id | IC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 2074 |
| Chain | Residue |
| D | PHE46 |
| D | LYS84 |
| D | TRP88 |
| D | HOH2173 |
| D | HOH2174 |
| E | LYS84 |
| site_id | IC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 2075 |
| Chain | Residue |
| C | GLU193 |
| C | ALA196 |
| C | ARG197 |
| E | GLU87 |
| E | EDO2127 |
| site_id | IC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 2076 |
| Chain | Residue |
| D | ARG91 |
| E | TRP88 |
| E | ARG91 |
| E | HIS92 |
| E | HOH315 |
| site_id | IC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO E 2077 |
| Chain | Residue |
| D | HIS123 |
| E | THR18 |
| site_id | IC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 2078 |
| Chain | Residue |
| E | VAL17 |
| E | THR18 |
| E | ILE102 |
| E | ALA103 |
| E | ASP104 |
| E | VAL109 |
| site_id | IC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 2079 |
| Chain | Residue |
| E | MSE15 |
| E | GLU16 |
| E | THR108 |
| E | ARG112 |
| E | HOH337 |
| site_id | IC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 2080 |
| Chain | Residue |
| C | ARG228 |
| C | ARG231 |
| C | ARG232 |
| C | GLU235 |
| site_id | IC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 2081 |
| Chain | Residue |
| C | LYS236 |
| C | LEU240 |
| D | ILE181 |
| D | GLY182 |
| D | GLU183 |
| D | TRP214 |
| D | THR216 |
| site_id | JC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 2082 |
| Chain | Residue |
| C | PRO237 |
| C | ALA238 |
| C | LYS239 |
| site_id | JC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 2083 |
| Chain | Residue |
| C | GLN65 |
| C | GLY68 |
| C | EDO2084 |
| H | GLY34 |
| H | TRP36 |
| H | ALA133 |
| site_id | JC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 2084 |
| Chain | Residue |
| C | GLN33 |
| C | GLY34 |
| C | LYS35 |
| C | EDO2083 |
| H | GLY34 |
| H | GLY68 |
| H | LYS162 |
| site_id | JC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 2085 |
| Chain | Residue |
| C | ILE181 |
| C | GLU183 |
| D | LEU240 |
| site_id | JC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO F 2086 |
| Chain | Residue |
| F | PRO43 |
| F | HIS123 |
| F | MSE145 |
| F | EDO2037 |
| site_id | JC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO F 2087 |
| Chain | Residue |
| F | VAL17 |
| F | THR18 |
| F | ILE102 |
| F | ALA103 |
| F | ASP104 |
| F | VAL109 |
| F | HOH998 |
| site_id | JC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 2088 |
| Chain | Residue |
| D | HOH2222 |
| E | LYS159 |
| E | LEU163 |
| E | ASP222 |
| site_id | JC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO E 2089 |
| Chain | Residue |
| E | ARG169 |
| E | TYR205 |
| site_id | JC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 2090 |
| Chain | Residue |
| E | TYR205 |
| E | ARG206 |
| E | SER207 |
| E | HOH1157 |
| E | EDO2042 |
| F | TYR242 |
| site_id | KC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO E 2091 |
| Chain | Residue |
| E | GLN195 |
| E | ARG199 |
| E | HOH522 |
| site_id | KC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 2092 |
| Chain | Residue |
| E | ALA196 |
| E | ARG197 |
| E | TRP210 |
| G | GLU87 |
| site_id | KC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO G 2093 |
| Chain | Residue |
| G | HIS21 |
| G | HIS29 |
| G | TYR30 |
| site_id | KC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO F 2094 |
| Chain | Residue |
| F | GLU87 |
| site_id | KC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO F 2095 |
| Chain | Residue |
| F | ALA58 |
| F | ARG96 |
| F | PRO98 |
| F | HOH553 |
| site_id | KC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO F 2096 |
| Chain | Residue |
| F | LYS159 |
| F | LYS162 |
| site_id | KC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO F 2097 |
| Chain | Residue |
| F | LEU163 |
| F | PRO217 |
| F | ALA218 |
| F | SER219 |
| F | ASP222 |
| site_id | KC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO F 2098 |
| Chain | Residue |
| F | GLY203 |
| F | TYR205 |
| site_id | KC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO I 2099 |
| Chain | Residue |
| H | THR18 |
| I | HIS123 |
| I | HOH2135 |
| J | THR191 |
| site_id | LC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO I 2100 |
| Chain | Residue |
| I | VAL17 |
| I | THR18 |
| I | ILE102 |
| I | ALA103 |
| I | VAL109 |
| I | HOH2147 |
| site_id | LC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO G 2101 |
| Chain | Residue |
| G | THR191 |
| G | HOH616 |
| H | HIS123 |
| I | THR18 |
| site_id | LC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO G 2102 |
| Chain | Residue |
| G | GLN195 |
| G | ARG199 |
| site_id | LC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO I 2103 |
| Chain | Residue |
| I | ILE181 |
| I | GLY182 |
| I | GLU183 |
| I | GLY184 |
| J | LYS236 |
| J | LEU240 |
| site_id | LC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO J 2104 |
| Chain | Residue |
| J | GLN195 |
| J | ARG199 |
| site_id | LC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO J 2105 |
| Chain | Residue |
| J | MSE200 |
| J | SER207 |
| J | LEU208 |
| J | ASP209 |
| J | EDO2106 |
| site_id | LC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO J 2106 |
| Chain | Residue |
| J | TYR205 |
| J | ARG206 |
| J | SER207 |
| J | EDO2105 |
| site_id | LC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO I 2107 |
| Chain | Residue |
| D | EDO2072 |
| I | ASP63 |
| I | ARG228 |
| I | TYR229 |
| I | ARG232 |
| I | HOH2206 |
| site_id | LC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO J 2108 |
| Chain | Residue |
| G | PRO217 |
| G | ALA218 |
| G | SER219 |
| G | HOH800 |
| J | ASP28 |
| J | VAL31 |
| J | SER32 |
| J | HOH2139 |
| J | HOH2191 |
| site_id | MC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO J 2109 |
| Chain | Residue |
| J | LYS86 |
| J | ILE89 |
| J | GLU90 |
| J | VAL95 |
| J | ARG96 |
| J | ILE97 |
| site_id | MC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO J 2110 |
| Chain | Residue |
| J | PRO217 |
| J | ALA218 |
| J | SER219 |
| J | ASP222 |
| site_id | MC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO H 2111 |
| Chain | Residue |
| G | GLU146 |
| H | GLY164 |
| H | ARG169 |
| H | HOH787 |
| site_id | MC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO G 2112 |
| Chain | Residue |
| G | GLY164 |
| G | ASP165 |
| G | ARG169 |
| G | HOH789 |
| site_id | MC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO H 2113 |
| Chain | Residue |
| C | HOH2229 |
| H | TYR30 |
| H | TYR61 |
| H | GLN65 |
| H | ASP70 |
| H | LEU71 |
| H | PHE99 |
| H | PRO100 |
| site_id | MC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO H 2114 |
| Chain | Residue |
| C | SER166 |
| C | HOH2190 |
| H | LEU163 |
| H | PRO217 |
| H | ALA218 |
| H | SER219 |
| H | ASP222 |
| site_id | MC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO I 2115 |
| Chain | Residue |
| I | THR192 |
| site_id | MC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 2116 |
| Chain | Residue |
| A | ARG134 |
| site_id | MC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 2117 |
| Chain | Residue |
| C | MSE15 |
| C | GLU16 |
| C | THR108 |
| C | VAL109 |
| C | ARG112 |
| C | HOH2197 |
| site_id | NC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 2118 |
| Chain | Residue |
| D | PRO43 |
| D | THR47 |
| D | HIS123 |
| D | MSE145 |
| E | PHE80 |
| site_id | NC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 2119 |
| Chain | Residue |
| C | ARG231 |
| D | ALA234 |
| D | GLU235 |
| D | HOH2205 |
| D | HOH2207 |
| site_id | NC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 2120 |
| Chain | Residue |
| E | LEU208 |
| E | ASP209 |
| F | TRP88 |
| F | HIS92 |
| site_id | NC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO I 2121 |
| Chain | Residue |
| I | THR47 |
| I | PRO48 |
| I | VAL49 |
| I | CYS50 |
| I | ARG126 |
| I | HOH2181 |
| site_id | NC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 2122 |
| Chain | Residue |
| A | THR18 |
| A | ALA103 |
| A | VAL109 |
| site_id | NC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO J 2123 |
| Chain | Residue |
| J | GLU16 |
| J | VAL17 |
| J | THR18 |
| J | EDO2061 |
| site_id | NC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2124 |
| Chain | Residue |
| A | LEU167 |
| A | ARG169 |
| A | PRO217 |
| A | HOH2197 |
| J | GLN204 |
| site_id | NC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 2125 |
| Chain | Residue |
| A | EDO2029 |
| B | TRP88 |
| B | ARG91 |
| B | HIS92 |
| site_id | NC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 2126 |
| Chain | Residue |
| C | TRP88 |
| C | ARG91 |
| C | HOH2233 |
| site_id | OC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO E 2127 |
| Chain | Residue |
| C | GLU193 |
| C | ARG197 |
| C | EDO2075 |
| E | ILE83 |
| E | LYS86 |
| E | GLU87 |
| E | GLU90 |
| site_id | OC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 2128 |
| Chain | Residue |
| C | ARG59 |
| C | ARG60 |
| C | ARG232 |
| D | GLU179 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00401","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16214169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18436649","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00401","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19819903","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
