1X0L
Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile, Thermus thermophilus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047046 | molecular_function | homoisocitrate dehydrogenase activity |
| B | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047046 | molecular_function | homoisocitrate dehydrogenase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27601325, ECO:0007744|PDB:4YB4 |
| Chain | Residue | Details |
| A | ALA70 | |
| B | ASN273 | |
| A | LYS171 | |
| A | ASN173 | |
| A | GLY261 | |
| A | ASN273 | |
| B | ALA70 | |
| B | LYS171 | |
| B | ASN173 | |
| B | GLY261 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:27601325, ECO:0007744|PDB:4YB4 |
| Chain | Residue | Details |
| A | SER72 | |
| B | ARG98 | |
| B | ARG118 | |
| B | TYR125 | |
| A | ARG85 | |
| A | ARG88 | |
| A | ARG98 | |
| A | ARG118 | |
| A | TYR125 | |
| B | SER72 | |
| B | ARG85 | |
| B | ARG88 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27601325, ECO:0000312|PDB:4YB4 |
| Chain | Residue | Details |
| A | ASP204 | |
| A | ASP228 | |
| A | ASP232 | |
| B | ASP204 | |
| B | ASP228 | |
| B | ASP232 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important for substrate specificity and discrimination against 3-isopropylmalate |
| Chain | Residue | Details |
| A | ARG85 | |
| B | ARG85 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | TYR125 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| B | ASP204 | |
| B | LYS171 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| B | TYR125 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | ASP204 | |
| A | LYS171 |
