1X08
Crystal structure of D26A mutant UPPs in complex with Mg, IPP and FsPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0008834 | molecular_function | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016094 | biological_process | polyprenol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043164 | biological_process | Gram-negative-bacterium-type cell wall biogenesis |
| A | 0045547 | molecular_function | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051301 | biological_process | cell division |
| A | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE FPS A 901 |
| Chain | Residue |
| A | ALA26 |
| A | LEU85 |
| A | ALA92 |
| A | TRP221 |
| A | HOH568 |
| A | HOH572 |
| A | HOH573 |
| A | HOH574 |
| A | IPE903 |
| A | GLY27 |
| A | ASN28 |
| A | GLY29 |
| A | ARG30 |
| A | HIS43 |
| A | ALA69 |
| A | ASN74 |
| A | ARG77 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FPS A 902 |
| Chain | Residue |
| A | ARG51 |
| A | LEU93 |
| A | GLU96 |
| A | HOH506 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPE A 903 |
| Chain | Residue |
| A | ILE24 |
| A | TYR68 |
| A | PHE70 |
| A | HOH826 |
| A | FPS901 |
Functional Information from PROSITE/UniProt
| site_id | PS01066 |
| Number of Residues | 18 |
| Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLVIRTGGehRiSnFLLW |
| Chain | Residue | Details |
| A | ASP190-TRP207 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | ALA26 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN74 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ALA26 | |
| A | HIS199 | |
| A | ARG200 | |
| A | GLU213 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15044730 |
| Chain | Residue | Details |
| A | TRP31 | |
| A | TRP75 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15044730 |
| Chain | Residue | Details |
| A | ARG39 | |
| A | HIS43 | |
| A | ARG77 | |
| A | ARG194 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER71 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Required for continued chain elongation |
| Chain | Residue | Details |
| A | ALA69 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Important for determining product length |
| Chain | Residue | Details |
| A | LEU137 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1f75 |
| Chain | Residue | Details |
| A | ARG30 | |
| A | ARG200 | |
| A | ARG39 | |
| A | ARG194 |
