1WZO

Crystal Structure of the HpcE from Thermus Thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008704	molecular_function	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
A	0016853	molecular_function	isomerase activity
A	0018773	molecular_function	acetylpyruvate hydrolase activity
A	0018800	molecular_function	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
A	0046872	molecular_function	metal ion binding
A	1901023	biological_process	4-hydroxyphenylacetate catabolic process
B	0003824	molecular_function	catalytic activity
B	0008704	molecular_function	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
B	0016853	molecular_function	isomerase activity
B	0018773	molecular_function	acetylpyruvate hydrolase activity
B	0018800	molecular_function	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
B	0046872	molecular_function	metal ion binding
B	1901023	biological_process	4-hydroxyphenylacetate catabolic process
C	0003824	molecular_function	catalytic activity
C	0008704	molecular_function	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
C	0016853	molecular_function	isomerase activity
C	0018773	molecular_function	acetylpyruvate hydrolase activity
C	0018800	molecular_function	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
C	0046872	molecular_function	metal ion binding
C	1901023	biological_process	4-hydroxyphenylacetate catabolic process
D	0003824	molecular_function	catalytic activity
D	0008704	molecular_function	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
D	0016853	molecular_function	isomerase activity
D	0018773	molecular_function	acetylpyruvate hydrolase activity
D	0018800	molecular_function	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
D	0046872	molecular_function	metal ion binding
D	1901023	biological_process	4-hydroxyphenylacetate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1007

Chain	Residue
A	GLU97
A	GLU99
A	ASP128
A	LYS146
A	HOH1012
A	HOH1030

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 1008

Chain	Residue
D	ARG140
D	PRO141
D	HOH1189
D	HOH1210
D	HOH1214
C	ARG140
D	ALA50
D	LEU51

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1001

Chain	Residue
A	VAL120
A	LEU121
A	VAL160
A	GLU161
A	VAL163
A	HOH1024
A	HOH1143

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1002

Chain	Residue
A	TRP37
A	HIS81
A	PHE157
A	GLY236
A	ALA237

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 1003

Chain	Residue
B	TRP37
B	HIS81
B	PHE157
B	GLY236
B	ALA237
B	HOH1200
B	HOH1202

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 1004

Chain	Residue
B	VAL120
B	LEU121
B	GLY122
B	TYR123
B	VAL160
B	GLU161
B	VAL163
B	HOH1040
B	HOH1114

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 1005

Chain	Residue
C	TYR17
C	TRP37
C	HIS81
C	PHE157
C	GLY236
C	ALA237

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 1006

Chain	Residue
D	TYR17
D	TRP37
D	HIS81
D	PHE157
D	GLY236
D	ALA237

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