1WXH

E.coli NAD Synthetase, NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003952	molecular_function	NAD+ synthase (glutamine-hydrolyzing) activity
A	0004359	molecular_function	glutaminase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006974	biological_process	DNA damage response
A	0008795	molecular_function	NAD+ synthase activity
A	0009435	biological_process	NAD+ biosynthetic process
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0034628	biological_process	'de novo' NAD+ biosynthetic process from L-aspartate
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD A 400

Chain	Residue
A	TYR33
A	PHE171
A	THR172
A	LYS173
A	ASP180
A	VAL225
A	ALA226
A	TRP254
A	HIS260
A	LYS261
A	HOH469
A	GLU70
A	HOH481
A	HOH519
A	HOH555
A	HOH559
A	HOH573
A	HOH583
A	HOH685
A	THR71
A	PHE132
A	ASN136
A	ARG140
A	TYR147
A	GLY155
A	PHE170

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00193","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00193","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00193","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WXG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00193","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00193","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15699042","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---