1WQ5
Crystal structure of tryptophan synthase alpha-subunit from Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0060090 | molecular_function | molecular adaptor activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0060090 | molecular_function | molecular adaptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| A | LEU69 |
| A | ARG70 |
| A | ALA71 |
| B | PHE1212 |
| B | GLY1213 |
| B | SER1233 |
| B | GLY1234 |
| B | SER1235 |
| B | HOH2003 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | PHE212 |
| A | GLY213 |
| A | SER233 |
| A | GLY234 |
| A | SER235 |
| A | HOH2002 |
| A | HOH2070 |
| B | LEU1069 |
| B | ARG1070 |
| B | ALA1071 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 503 |
| Chain | Residue |
| B | ARG1179 |
| B | LEU1193 |
| B | GLN1210 |
| B | HOH2024 |
| B | HOH2074 |
| B | HOH2089 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | ARG179 |
| A | LEU193 |
| A | GLN210 |
| A | HOH2104 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 505 |
| Chain | Residue |
| A | ARG171 |
| B | GLY1110 |
| B | ILE1111 |
| B | ASP1112 |
| B | HOH2054 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 506 |
| Chain | Residue |
| B | GOL606 |
| B | LYS1120 |
| B | ASP1159 |
| B | ASP1160 |
| B | ARG1188 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 507 |
| Chain | Residue |
| B | ILE1030 |
| B | GLU1031 |
| B | HOH2009 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 508 |
| Chain | Residue |
| A | GLU247 |
| A | PRO248 |
| A | GLU249 |
| A | LYS250 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 509 |
| Chain | Residue |
| A | LYS35 |
| B | GLU1247 |
| B | PRO1248 |
| B | GLU1249 |
| B | LYS1250 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 510 |
| Chain | Residue |
| A | ASN157 |
| A | ALA158 |
| A | ASP159 |
| A | LEU162 |
| A | ARG188 |
| A | HOH2139 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 511 |
| Chain | Residue |
| A | ARG70 |
| B | SER1215 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 512 |
| Chain | Residue |
| A | GLY29 |
| A | ILE30 |
| A | GLU31 |
| A | HOH2046 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 513 |
| Chain | Residue |
| A | LYS120 |
| A | ASP160 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | LYS120 |
| A | HIS195 |
| A | LYS199 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | ARG140 |
| A | LEU144 |
| A | PRO150 |
| A | SER168 |
| A | TYR169 |
| A | ARG171 |
| B | PHE1107 |
| B | ASN1108 |
| B | LYS1109 |
| B | HOH2099 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 603 |
| Chain | Residue |
| A | TYR115 |
| A | VAL126 |
| A | LEU127 |
| A | VAL128 |
| A | VAL131 |
| A | SER136 |
| A | PHE139 |
| A | PRO150 |
| A | ILE151 |
| A | PHE152 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 604 |
| Chain | Residue |
| B | TYR1115 |
| B | VAL1126 |
| B | LEU1127 |
| B | VAL1128 |
| B | SER1136 |
| B | PHE1139 |
| B | PRO1150 |
| B | ILE1151 |
| B | PHE1152 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 605 |
| Chain | Residue |
| A | GLN90 |
| A | LYS120 |
| A | VAL121 |
| A | HIS195 |
| A | ALA86 |
| A | ARG89 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 606 |
| Chain | Residue |
| B | SO4506 |
| B | LYS1120 |
| B | ASP1160 |
| B | LYS1199 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 607 |
| Chain | Residue |
| A | GLU2 |
| A | ARG171 |
| A | GLY172 |
| A | ALA206 |
| A | HOH2120 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 608 |
| Chain | Residue |
| A | SER55 |
| A | PHE72 |
| A | HOH2110 |
| B | THR1024 |
| B | GLY1051 |
| B | ILE1052 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGiPFSDPLADG |
| Chain | Residue | Details |
| A | LEU48-GLY61 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1geq |
| Chain | Residue | Details |
| A | TYR175 | |
| A | GLU49 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1geq |
| Chain | Residue | Details |
| B | GLU1049 | |
| B | TYR1175 |
