1WPD

Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity
A	0015459	molecular_function	potassium channel regulator activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS01138
Number of Residues	23
Details	SCORP_SHORT_TOXIN Scorpion short toxins signature. CyapCrkqtgcpy.GKCMnrkCkC

Chain	Residue	Details
A	CYS9-CYS31

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Critical for activity (is inserted in the pore, pointing downward) => ECO:0000305|PubMed:10631983

Chain	Residue	Details
A	LYS23

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Aromatic residue of the functional dyad => ECO:0000250

Chain	Residue	Details
A	ASN32

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Cysteine amide => ECO:0000269|PubMed:9359871

Chain	Residue	Details
A	CYS34

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site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Important for activity => ECO:0000305|PubMed:10631983

Chain	Residue	Details
A	TYR21
A	MET25
A	ASN26
A	ARG33

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