1WO8
Crystal structure of methylglyoxal synthase from Thermus thermophilus HB8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008929 | molecular_function | methylglyoxal synthase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019242 | biological_process | methylglyoxal biosynthetic process |
| B | 0005829 | cellular_component | cytosol |
| B | 0008929 | molecular_function | methylglyoxal synthase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019242 | biological_process | methylglyoxal biosynthetic process |
| C | 0005829 | cellular_component | cytosol |
| C | 0008929 | molecular_function | methylglyoxal synthase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019242 | biological_process | methylglyoxal biosynthetic process |
| D | 0005829 | cellular_component | cytosol |
| D | 0008929 | molecular_function | methylglyoxal synthase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019242 | biological_process | methylglyoxal biosynthetic process |
| E | 0005829 | cellular_component | cytosol |
| E | 0008929 | molecular_function | methylglyoxal synthase activity |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019242 | biological_process | methylglyoxal biosynthetic process |
| F | 0005829 | cellular_component | cytosol |
| F | 0008929 | molecular_function | methylglyoxal synthase activity |
| F | 0016829 | molecular_function | lyase activity |
| F | 0019242 | biological_process | methylglyoxal biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | LYS13 |
| A | THR35 |
| A | THR37 |
| A | THR38 |
| A | SER55 |
| A | GLY56 |
| A | HOH1061 |
| A | HOH1073 |
| A | HOH1143 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
| Chain | Residue |
| B | LYS13 |
| B | THR35 |
| B | GLY36 |
| B | THR37 |
| B | THR38 |
| B | SER55 |
| B | GLY56 |
| B | HOH1066 |
| B | HOH1083 |
| B | HOH1118 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1003 |
| Chain | Residue |
| C | LYS13 |
| C | THR35 |
| C | THR37 |
| C | THR38 |
| C | SER55 |
| C | GLY56 |
| C | HOH1021 |
| C | HOH1062 |
| C | HOH1099 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1004 |
| Chain | Residue |
| D | LYS13 |
| D | THR35 |
| D | THR37 |
| D | THR38 |
| D | SER55 |
| D | GLY56 |
| D | HOH1111 |
| D | HOH1144 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1005 |
| Chain | Residue |
| E | LYS13 |
| E | THR35 |
| E | THR37 |
| E | THR38 |
| E | SER55 |
| E | GLY56 |
| E | HOH1037 |
| E | HOH1102 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 F 1006 |
| Chain | Residue |
| F | LYS13 |
| F | THR35 |
| F | GLY36 |
| F | THR37 |
| F | THR38 |
| F | SER55 |
| F | GLY56 |
| F | HOH1077 |
| F | HOH1083 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1007 |
| Chain | Residue |
| D | GLN43 |
| D | ARG52 |
| D | HOH1028 |
| D | HOH1131 |
Functional Information from PROSITE/UniProt
| site_id | PS01335 |
| Number of Residues | 9 |
| Details | METHYLGLYOXAL_SYNTH Methylglyoxal synthase active site. SGPLGGDlQ |
| Chain | Residue | Details |
| A | SER55-GLN63 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 125 |
| Details | Domain: {"description":"MGS-like","evidences":[{"source":"HAMAP-Rule","id":"MF_00549","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00549","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00549","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b93 |
| Chain | Residue | Details |
| A | ASP61 | |
| A | ASP81 | |
| A | GLY56 | |
| A | HIS88 | |
| A | ASP91 | |
| A | HIS9 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b93 |
| Chain | Residue | Details |
| B | ASP61 | |
| B | ASP81 | |
| B | GLY56 | |
| B | HIS88 | |
| B | ASP91 | |
| B | HIS9 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b93 |
| Chain | Residue | Details |
| C | ASP61 | |
| C | ASP81 | |
| C | GLY56 | |
| C | HIS88 | |
| C | ASP91 | |
| C | HIS9 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b93 |
| Chain | Residue | Details |
| D | ASP61 | |
| D | ASP81 | |
| D | GLY56 | |
| D | HIS88 | |
| D | ASP91 | |
| D | HIS9 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b93 |
| Chain | Residue | Details |
| E | ASP61 | |
| E | ASP81 | |
| E | GLY56 | |
| E | HIS88 | |
| E | ASP91 | |
| E | HIS9 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b93 |
| Chain | Residue | Details |
| F | ASP61 | |
| F | ASP81 | |
| F | GLY56 | |
| F | HIS88 | |
| F | ASP91 | |
| F | HIS9 |
