Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004392 | molecular_function | heme oxygenase (decyclizing) activity |
| A | 0006788 | biological_process | heme oxidation |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004392 | molecular_function | heme oxygenase (decyclizing) activity |
| B | 0006788 | biological_process | heme oxidation |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0042167 | biological_process | heme catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | SER26 |
| A | THR27 |
| A | HOH3047 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
| Chain | Residue |
| B | ARG112 |
| B | HIS192 |
| B | HOH1079 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | ARG97 |
| A | HOH3027 |
| A | HOH3115 |
| A | HOH3124 |
| B | HOH1099 |
| A | GLN14 |
| A | GLU81 |
| A | ALA84 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | GLN58 |
| A | LYS173 |
| A | ARG177 |
| A | HEM901 |
| A | HOH3138 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | ALA69 |
| A | GLU70 |
| A | SER71 |
| A | HOH3048 |
| A | HOH3058 |
| A | HOH3068 |
| B | LYS168 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | LEU169 |
| A | LYS170 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1007 |
| Chain | Residue |
| A | THR101 |
| A | SER103 |
| B | THR27 |
| B | HOH1072 |
| B | HOH1143 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1008 |
| Chain | Residue |
| B | PRO75 |
| B | ALA76 |
| B | ASN78 |
| B | HOH1159 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1009 |
| Chain | Residue |
| A | HIS162 |
| B | ASN91 |
| B | SER93 |
| B | GLU95 |
| B | TRP96 |
| B | ARG99 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1010 |
| Chain | Residue |
| B | ALA69 |
| B | GLU70 |
| B | SER71 |
| B | HOH1025 |
| B | HOH1034 |
| B | HOH1141 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1011 |
| Chain | Residue |
| B | GLN58 |
| B | ARG177 |
| B | HOH1119 |
| B | HOH1138 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 3001 |
| Chain | Residue |
| A | GLU115 |
| B | VAL39 |
| B | ALA40 |
| B | HOH1182 |
| site_id | BC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM A 901 |
| Chain | Residue |
| A | LYS13 |
| A | HIS20 |
| A | GLU24 |
| A | LEU33 |
| A | ARG117 |
| A | TYR130 |
| A | VAL131 |
| A | GLY135 |
| A | SER138 |
| A | VAL142 |
| A | LYS173 |
| A | ARG177 |
| A | PHE201 |
| A | ASN204 |
| A | PHE208 |
| A | SO41004 |
| A | HOH3005 |
| A | HOH3017 |
| A | HOH3107 |
| A | HOH3138 |
| site_id | BC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEM B 902 |
| Chain | Residue |
| B | LYS13 |
| B | HIS20 |
| B | GLN58 |
| B | TYR130 |
| B | VAL131 |
| B | GLY135 |
| B | SER138 |
| B | ARG177 |
| B | PHE201 |
| B | PHE208 |
| B | HOH1032 |
| B | HOH1059 |
| B | HOH1091 |
| B | HOH1196 |
Functional Information from PROSITE/UniProt
| site_id | PS00593 |
| Number of Residues | 11 |
| Details | HEME_OXYGENASE Heme oxygenase signature. LVAHHYVRYLG |
| Chain | Residue | Details |
| A | LEU125-GLY135 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1wnw |
| Chain | Residue | Details |
| A | GLU136 | |
| A | GLY140 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1wnw |
| Chain | Residue | Details |
| B | GLU136 | |
| B | GLY140 | |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 795 |
| Chain | Residue | Details |
| A | HIS25 | metal ligand |
| A | TYR53 | activator, electrostatic stabiliser |
| A | VAL131 | activator |
| A | ARG132 | activator |
| A | GLY135 | steric role |
| A | GLU136 | modifies pKa |
| A | GLY140 | steric role |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 795 |
| Chain | Residue | Details |
| B | HIS25 | metal ligand |
| B | TYR53 | activator, electrostatic stabiliser |
| B | VAL131 | activator |
| B | ARG132 | activator |
| B | GLY135 | steric role |
| B | GLU136 | modifies pKa |
| B | GLY140 | steric role |
