Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004392 | molecular_function | heme oxygenase (decyclizing) activity |
| A | 0006788 | biological_process | heme oxidation |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004392 | molecular_function | heme oxygenase (decyclizing) activity |
| B | 0006788 | biological_process | heme oxidation |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0042167 | biological_process | heme catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004392 | molecular_function | heme oxygenase (decyclizing) activity |
| C | 0006788 | biological_process | heme oxidation |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0042167 | biological_process | heme catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 1001 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 1002 |
| Chain | Residue |
| B | MET29 |
| B | HEM902 |
| B | HOH4097 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 1003 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 1006 |
| Chain | Residue |
| A | IOD1007 |
| A | HOH2083 |
| A | HOH2132 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 1007 |
| Chain | Residue |
| A | IOD1006 |
| A | HOH2032 |
| A | HEM901 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 1008 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA B 4001 |
| Chain | Residue |
| B | ASP108 |
| B | GLN206 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA B 4002 |
| Chain | Residue |
| B | HOH4062 |
| B | HOH4157 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2001 |
| Chain | Residue |
| C | VAL82 |
| C | ARG85 |
| C | GLY159 |
| C | HOH2091 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2002 |
| Chain | Residue |
| C | TYR161 |
| C | HIS162 |
| C | PHE163 |
| C | LEU169 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2003 |
| Chain | Residue |
| B | SER26 |
| B | THR27 |
| B | HIS205 |
| B | HOH4105 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2004 |
| Chain | Residue |
| B | VAL82 |
| B | ARG85 |
| B | GLY159 |
| B | HOH4017 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2005 |
| Chain | Residue |
| B | LYS170 |
| B | LYS173 |
| B | ARG177 |
| B | HOH4078 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2006 |
| Chain | Residue |
| A | VAL202 |
| B | GLY165 |
| B | ILE166 |
| B | ALA167 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2007 |
| Chain | Residue |
| A | PRO123 |
| A | GLU188 |
| A | GLN189 |
| A | HIS192 |
| A | HOH2104 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2008 |
| Chain | Residue |
| B | ARG44 |
| B | ARG99 |
| B | HOH4111 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2009 |
| Chain | Residue |
| A | ARG97 |
| A | HOH2016 |
| A | HOH2137 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2010 |
| Chain | Residue |
| C | LYS89 |
| C | LEU90 |
| C | GLY152 |
| C | VAL153 |
| C | ASP154 |
| C | ALA157 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2011 |
| Chain | Residue |
| A | LYS13 |
| A | LYS173 |
| A | ARG177 |
| A | HOH2077 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2012 |
| Chain | Residue |
| B | HOH4035 |
| B | HOH4053 |
| C | HOH2059 |
| site_id | CC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM A 901 |
| Chain | Residue |
| A | LYS13 |
| A | HIS20 |
| A | ALA23 |
| A | GLU24 |
| A | LEU33 |
| A | TYR130 |
| A | VAL131 |
| A | GLY135 |
| A | SER138 |
| A | GLY139 |
| A | ARG177 |
| A | ASN204 |
| A | PHE208 |
| A | IOD1007 |
| A | HOH2033 |
| A | HOH2126 |
| A | HOH2138 |
| site_id | CC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE HEM B 902 |
| Chain | Residue |
| B | LYS13 |
| B | HIS20 |
| B | ALA23 |
| B | LEU33 |
| B | TYR130 |
| B | VAL131 |
| B | GLY135 |
| B | SER138 |
| B | ARG177 |
| B | PHE201 |
| B | ASN204 |
| B | PHE208 |
| B | IOD1002 |
| B | HOH4010 |
| B | HOH4078 |
| B | HOH4159 |
| site_id | CC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE HEM C 903 |
| Chain | Residue |
| C | ALA23 |
| C | LEU33 |
| C | TYR130 |
| C | VAL131 |
| C | GLY135 |
| C | SER138 |
| C | ARG177 |
| C | PHE201 |
| C | ASN204 |
| C | HOH2062 |
| C | HOH2085 |
| C | LYS13 |
| C | HIS20 |
Functional Information from PROSITE/UniProt
| site_id | PS00593 |
| Number of Residues | 11 |
| Details | HEME_OXYGENASE Heme oxygenase signature. LVAHHYVRYLG |
| Chain | Residue | Details |
| A | LEU125-GLY135 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: axial binding residue => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS20 | |
| B | HIS20 | |
| C | HIS20 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 795 |
| Chain | Residue | Details |
| A | HIS25 | metal ligand |
| A | TYR53 | activator, electrostatic stabiliser |
| A | VAL131 | activator |
| A | ARG132 | activator |
| A | GLY135 | steric role |
| A | ASN136 | modifies pKa |
| A | GLY140 | steric role |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 795 |
| Chain | Residue | Details |
| B | HIS25 | metal ligand |
| B | TYR53 | activator, electrostatic stabiliser |
| B | VAL131 | activator |
| B | ARG132 | activator |
| B | GLY135 | steric role |
| B | ASN136 | modifies pKa |
| B | GLY140 | steric role |
| site_id | MCSA3 |
| Number of Residues | 7 |
| Details | M-CSA 795 |
| Chain | Residue | Details |
| C | HIS25 | metal ligand |
| C | TYR53 | activator, electrostatic stabiliser |
| C | VAL131 | activator |
| C | ARG132 | activator |
| C | GLY135 | steric role |
| C | ASN136 | modifies pKa |
| C | GLY140 | steric role |
