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1WNT

Structure of the tetrameric form of Human L-Xylulose Reductase

Functional Information from GO Data
ChainGOidnamespacecontents
A0004090molecular_functioncarbonyl reductase (NADPH) activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005829cellular_componentcytosol
A0005881cellular_componentcytoplasmic microtubule
A0005886cellular_componentplasma membrane
A0005902cellular_componentmicrovillus
A0005903cellular_componentbrush border
A0005997biological_processxylulose metabolic process
A0006006biological_processglucose metabolic process
A0006739biological_processNADP metabolic process
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
A0016655molecular_functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
A0019640biological_processglucuronate catabolic process to xylulose 5-phosphate
A0042732biological_processD-xylose metabolic process
A0042802molecular_functionidentical protein binding
A0050038molecular_functionL-xylulose reductase (NADPH) activity
A0070062cellular_componentextracellular exosome
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0004090molecular_functioncarbonyl reductase (NADPH) activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005829cellular_componentcytosol
B0005881cellular_componentcytoplasmic microtubule
B0005886cellular_componentplasma membrane
B0005902cellular_componentmicrovillus
B0005903cellular_componentbrush border
B0005997biological_processxylulose metabolic process
B0006006biological_processglucose metabolic process
B0006739biological_processNADP metabolic process
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
B0016655molecular_functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
B0019640biological_processglucuronate catabolic process to xylulose 5-phosphate
B0042732biological_processD-xylose metabolic process
B0042802molecular_functionidentical protein binding
B0050038molecular_functionL-xylulose reductase (NADPH) activity
B0070062cellular_componentextracellular exosome
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0004090molecular_functioncarbonyl reductase (NADPH) activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005829cellular_componentcytosol
C0005881cellular_componentcytoplasmic microtubule
C0005886cellular_componentplasma membrane
C0005902cellular_componentmicrovillus
C0005903cellular_componentbrush border
C0005997biological_processxylulose metabolic process
C0006006biological_processglucose metabolic process
C0006739biological_processNADP metabolic process
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
C0016655molecular_functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
C0019640biological_processglucuronate catabolic process to xylulose 5-phosphate
C0042732biological_processD-xylose metabolic process
C0042802molecular_functionidentical protein binding
C0050038molecular_functionL-xylulose reductase (NADPH) activity
C0070062cellular_componentextracellular exosome
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0004090molecular_functioncarbonyl reductase (NADPH) activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005829cellular_componentcytosol
D0005881cellular_componentcytoplasmic microtubule
D0005886cellular_componentplasma membrane
D0005902cellular_componentmicrovillus
D0005903cellular_componentbrush border
D0005997biological_processxylulose metabolic process
D0006006biological_processglucose metabolic process
D0006739biological_processNADP metabolic process
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
D0016655molecular_functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
D0019640biological_processglucuronate catabolic process to xylulose 5-phosphate
D0042732biological_processD-xylose metabolic process
D0042802molecular_functionidentical protein binding
D0050038molecular_functionL-xylulose reductase (NADPH) activity
D0070062cellular_componentextracellular exosome
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE NAP A 245
ChainResidue
AGLY14
AASP60
ALEU61
AGLY62
AASN83
AALA85
AARG102
AVAL106
AVAL134
ASER135
ATYR149
AGLY16
ALYS153
APRO179
ATHR180
AVAL181
AVAL182
ATHR184
ASER185
AMET186
AGLY187
AHOH249
ALYS17
AGLY18
AILE19
ASER38
AARG39
ATHR40
AVAL59

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE NAP B 1245
ChainResidue
BGLY14
BGLY16
BLYS17
BGLY18
BILE19
BSER38
BARG39
BTHR40
BVAL59
BASP60
BLEU61
BGLY62
BASN83
BALA85
BVAL106
BVAL134
BTYR149
BLYS153
BTHR180
BVAL182
BTHR184
BSER185
BMET186
BGLY187

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NAP C 2245
ChainResidue
CGLY14
CGLY16
CLYS17
CGLY18
CILE19
CSER38
CARG39
CTHR40
CASP43
CVAL59
CLEU61
CASN83
CALA85
CVAL106
CVAL134
CTYR149
CLYS153
CPRO179
CTHR180
CVAL181
CVAL182
CTHR184
CMET186
CGLY187
CHOH2250

site_idAC4
Number of Residues29
DetailsBINDING SITE FOR RESIDUE NAP D 3245
ChainResidue
DTHR180
DVAL181
DVAL182
DTHR184
DSER185
DMET186
DGLY187
DHOH3275
DGLY14
DGLY16
DLYS17
DGLY18
DILE19
DSER38
DARG39
DTHR40
DASP43
DVAL59
DLEU61
DASN83
DALA84
DALA85
DARG102
DVAL106
DVAL134
DSER135
DTYR149
DLYS153
DPRO179

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SqcsqravtnHsvYCSTKGALdMLTkVMA
ChainResidueDetails
ASER136-ALA164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ATYR149
BTYR149
CTYR149
DTYR149

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:15103634
ChainResidueDetails
ALEU11
DLEU11
DSER136
DLYS153
ASER136
ALYS153
BLEU11
BSER136
BLYS153
CLEU11
CSER136
CLYS153

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:12665801, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
AMET1
BMET1
CMET1
DMET1

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
AARG21
BARG21
CARG21
DARG21

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER46
BSER46
CSER46
DSER46

218853

數據於2024-04-24公開中

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